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Med13l mediator complex subunit 13-like [ Mus musculus (house mouse) ]

Gene ID: 76199, updated on 5-Mar-2024

Summary

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Official Symbol
Med13lprovided by MGI
Official Full Name
mediator complex subunit 13-likeprovided by MGI
Primary source
MGI:MGI:2670178
See related
Ensembl:ENSMUSG00000018076 AllianceGenome:MGI:2670178
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Thrap2; Trap240L; mKIAA1025; 2210413I17Rik; 6330591G05Rik; 9030618F05Rik
Summary
Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within transcription by RNA polymerase II. Part of mediator complex. Human ortholog(s) of this gene implicated in dextro-looped transposition of the great arteries. Orthologous to human MED13L (mediator complex subunit 13L). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 10.1), spleen adult (RPKM 6.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 59.1 cM
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (118698363..118903503)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (118560330..118765438)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene basic transcription factor 3, pseudogene 11 Neighboring gene predicted gene, 46921 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:119020268-119020484 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:119040971-119041080 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:119126693-119126894 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:119128855-119129008 Neighboring gene STARR-seq mESC enhancer starr_14210 Neighboring gene predicted gene, 42015 Neighboring gene RIKEN cDNA 4930413E15 gene Neighboring gene STARR-seq mESC enhancer starr_14211

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MED13L and its disease-associated variants influence the dendritic development of cerebral cortical neurons in the mammalian brain. Hamada N, et al. J Neurochem, 2023 May. PMID 36798993
  2. Expression Analyses of Mediator Complex Subunit 13-Like: A Responsible Gene for Neurodevelopmental Disorders during Mouse Brain Development. Hamada N, et al. Dev Neurosci, 2021. PMID 33794529
  3. Analysis of Polymorphisms in the Mediator Complex Subunit 13-like (Med13L) Gene in the Context of Immune Function and Development of Experimental Arthritis. Sardar S, et al. Arch Immunol Ther Exp (Warsz), 2018 Oct. PMID 29951696, Free PMC Article
  4. Mediator complex component MED13 regulates zygotic genome activation and is required for postimplantation development in the mouse. Miao YL, et al. Biol Reprod, 2018 Apr 1. PMID 29325037, Free PMC Article
  5. cDNA cloning and characterization of the human THRAP2 gene which maps to chromosome 12q24, and its mouse ortholog Thrap2. Musante L, et al. Gene, 2004 May 12. PMID 15145061

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MED13L and its disease-associated variants influence the dendritic development of cerebral cortical neurons in the mammalian brain.
    Title: MED13L and its disease-associated variants influence the dendritic development of cerebral cortical neurons in the mammalian brain.
  2. Expression Analyses of Mediator Complex Subunit 13-Like: A Responsible Gene for Neurodevelopmental Disorders during Mouse Brain Development.
    Title: Expression Analyses of Mediator Complex Subunit 13-Like: A Responsible Gene for Neurodevelopmental Disorders during Mouse Brain Development.
  3. this study shows that Med13L polymorphisms between the B10.RIII and RIIIS/J mouse strains do not affect immune phenotype, collagen-induced arthritis development and autoantibody production in these mice
    Title: Analysis of Polymorphisms in the Mediator Complex Subunit 13-like (Med13L) Gene in the Context of Immune Function and Development of Experimental Arthritis.
  4. Transcripts were most abundant in heart.
    Title: cDNA cloning and characterization of the human THRAP2 gene which maps to chromosome 12q24, and its mouse ortholog Thrap2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within transcription by RNA polymerase II IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
part_of mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mediator of RNA polymerase II transcription subunit 13-like
Names
thyroid hormone receptor associated protein 2
thyroid hormone receptor-associated protein complex 240 kDa component-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347445.2 → NP_001334374.1  mediator of RNA polymerase II transcription subunit 13-like isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC117585, AC129552
    Consensus CDS
    CCDS84948.1
    UniProtKB/Swiss-Prot
    Q3TRF4, Q3UQI8, Q6JPI3, Q80TM3, Q80WQ0
    UniProtKB/TrEMBL
    A0A0J9YUA8
    Related
    ENSMUSP00000144092.2, ENSMUST00000201010.2

  2. NM_172424.5 → NP_766012.3  mediator of RNA polymerase II transcription subunit 13-like isoform 2

    See identical proteins and their annotated locations for NP_766012.3

    Status: VALIDATED

    Source sequence(s)
    AC117585, AC129552
    Consensus CDS
    CCDS57375.1
    UniProtKB/Swiss-Prot
    Q3TRF4, Q3UQI8, Q6JPI3, Q80TM3, Q80WQ0
    UniProtKB/TrEMBL
    E9QLJ3
    Related
    ENSMUSP00000098379.5, ENSMUST00000100816.8
    Conserved Domains (2) summary
    pfam06333
    Location:1675 → 2194
    Med13_C; Mediator complex subunit 13 C-terminal
    pfam11597
    Location:16 → 380
    Med13_N; Mediator complex subunit 13 N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    118698363..118903503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254882.2 → XP_030110742.1  mediator of RNA polymerase II transcription subunit 13-like isoform X2

    UniProtKB/Swiss-Prot
    Q3TRF4, Q3UQI8, Q6JPI3, Q80TM3, Q80WQ0
    Conserved Domains (3) summary
    pfam06333
    Location:1792 → 2195
    Med13_C; Mediator complex subunit 13 C-terminal
    pfam11597
    Location:11 → 287
    Med13_N; Mediator complex subunit 13 N-terminal
    pfam18296
    Location:1414 → 1756
    MID_MedPIWI; MID domain of medPIWI

  2. XM_011248248.4 → XP_011246550.1  mediator of RNA polymerase II transcription subunit 13-like isoform X1

    UniProtKB/Swiss-Prot
    Q3TRF4, Q3UQI8, Q6JPI3, Q80TM3, Q80WQ0
    Conserved Domains (3) summary
    pfam06333
    Location:1792 → 2204
    Med13_C; Mediator complex subunit 13 C-terminal
    pfam11597
    Location:11 → 287
    Med13_N; Mediator complex subunit 13 N-terminal
    pfam18296
    Location:1414 → 1756
    MID_MedPIWI; MID domain of medPIWI

  3. XM_036165591.1 → XP_036021484.1  mediator of RNA polymerase II transcription subunit 13-like isoform X3

    UniProtKB/Swiss-Prot
    Q3TRF4, Q3UQI8, Q6JPI3, Q80TM3, Q80WQ0
    Conserved Domains (2) summary
    pfam06333
    Location:1659 → 2071
    Med13_C; Mediator complex subunit 13 C-terminal
    pfam18296
    Location:1281 → 1623
    MID_MedPIWI; MID domain of medPIWI

  4. XM_030254883.1 → XP_030110743.1  mediator of RNA polymerase II transcription subunit 13-like isoform X3

    UniProtKB/Swiss-Prot
    Q3TRF4, Q3UQI8, Q6JPI3, Q80TM3, Q80WQ0
    Conserved Domains (2) summary
    pfam06333
    Location:1659 → 2071
    Med13_C; Mediator complex subunit 13 C-terminal
    pfam18296
    Location:1281 → 1623
    MID_MedPIWI; MID domain of medPIWI
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6JPI3.2 GenPept UniProtKB/Swiss-Prot:Q6JPI3

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