Celf6 CUGBP, Elav-like family member 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Celf6provided by MGI
Official Full Name: CUGBP, Elav-like family member 6provided by MGI
Primary source: MGI:MGI:1923433
See related: Ensembl:ENSMUSG00000032297 AllianceGenome:MGI:1923433
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Brunol6; 6330569O16Rik
Summary: Predicted to enable mRNA binding activity. Acts upstream of or within serotonergic synaptic transmission and vocalization behavior. Located in cytoplasm. Is expressed in several structures, including brain; spinal cord; stomach; testis; and trigeminal ganglion. Orthologous to human CELF6 (CUGBP Elav-like family member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 4.7), testis adult (RPKM 3.2) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 B; 9 32.02 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (59485587..59516316)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (59578287..59609033)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CLIP and Massively Parallel Functional Analysis of CELF6 Reveal a Role in Destabilizing Synaptic Gene mRNAs through Interaction with 3' UTR Elements.
Title: CLIP and Massively Parallel Functional Analysis of CELF6 Reveal a Role in Destabilizing Synaptic Gene mRNAs through Interaction with 3' UTR Elements.
Celf6 mutant mice exhibited impaired conditioned learning to both reward and aversive stimuli.
Title: Loss of CELF6 RNA binding protein impairs cocaine conditioned place preference and contextual fear conditioning.
Results suggest that disruption of CUG-BP, Elav-like factor 6 expression in hypothalamic nuclei may impact a variety of behaviors downstream of neuropeptide activity, while disruption in neuromodulatory transmitter expressing areas such as the ventral tegmental area, substantia nigra, raphe nuclei and locus coeruleus may have far-reaching influences on overall brain activity.
Title: The RNA-binding protein Celf6 is highly expressed in diencephalic nuclei and neuromodulatory cell populations of the mouse brain.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (4)

General gene information

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Markers

RH48983 (e-PCR)
- UniSTS:92930

Brunol6 (e-PCR), detects polymorphism
- UniSTS:479078

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splice site recognition	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synaptic transmission, serotonergic	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vocalization behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CUGBP Elav-like family member 6

Names: CUG-BP- and ETR-3-like factor 6; RNA-binding protein BRUNOL-6; bruno-like 6, RNA binding protein; bruno-like protein 6

NP_001298021.1

EC 3.2.1.52

NP_001348028.1

EC 3.2.1.52

NP_001400450.1

EC 3.2.1.52

NP_001400451.1

EC 3.2.1.52

NP_001400452.1

EC 3.2.1.52

NP_001400453.1

EC 3.2.1.52

NP_001400454.1

EC 3.2.1.52

NP_001400455.1

EC 3.2.1.52

NP_001400456.1

EC 3.2.1.52

NP_001400457.1

EC 3.2.1.52

NP_780444.2

EC 3.2.1.52

XP_006511606.1

EC 3.2.1.52

XP_006511608.1

EC 3.2.1.52

XP_011241136.1

EC 3.2.1.52

XP_017169170.1

EC 3.2.1.52

XP_036011268.1

EC 3.2.1.52

XP_036011269.1

EC 3.2.1.52

XP_036011270.1

EC 3.2.1.52

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001311092.3 → NP_001298021.1 CUGBP Elav-like family member 6 isoform 2

Status: VALIDATED

Source sequence(s)

AC123817

Consensus CDS

CCDS81012.1

UniProtKB/TrEMBL

D3YX51

Related

ENSMUSP00000112403.2, ENSMUST00000118164.3

Conserved Domains (3) summary

cd12635
Location:18 → 98

RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

cd12639
Location:255 → 333

RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

cl25887
Location:32 → 256

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
NM_001361099.2 → NP_001348028.1 CUGBP Elav-like family member 6 isoform 3

Status: VALIDATED

Source sequence(s)

AC123817

Consensus CDS

CCDS90585.1

Related

ENSMUSP00000113196.2, ENSMUST00000121266.8

Conserved Domains (3) summary

TIGR01628
Location:32 → 257

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12639
Location:256 → 334

RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

cd12635
Location:18 → 98

RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
NM_001413521.1 → NP_001400450.1 CUGBP Elav-like family member 6 isoform 4

Status: VALIDATED

Source sequence(s)

AC123817

UniProtKB/TrEMBL

D3YU11

Related

ENSMUSP00000112755.2, ENSMUST00000118549.8
NM_001413522.1 → NP_001400451.1 CUGBP Elav-like family member 6 isoform 5

Status: VALIDATED

Source sequence(s)

AC123817
NM_001413523.1 → NP_001400452.1 CUGBP Elav-like family member 6 isoform 6

Status: VALIDATED

Source sequence(s)

AC123817
NM_001413524.1 → NP_001400453.1 CUGBP Elav-like family member 6 isoform 7

Status: VALIDATED

Source sequence(s)

AC123817
NM_001413525.1 → NP_001400454.1 CUGBP Elav-like family member 6 isoform 8

Status: VALIDATED

Source sequence(s)

AC123817
NM_001413526.1 → NP_001400455.1 CUGBP Elav-like family member 6 isoform 3

Status: VALIDATED

Source sequence(s)

AC123817
NM_001413527.1 → NP_001400456.1 CUGBP Elav-like family member 6 isoform 3

Status: VALIDATED

Source sequence(s)

AC123817
NM_001413528.1 → NP_001400457.1 CUGBP Elav-like family member 6 isoform 9

Status: VALIDATED

Source sequence(s)

AC123817
NM_175235.4 → NP_780444.2 CUGBP Elav-like family member 6 isoform 1

See identical proteins and their annotated locations for NP_780444.2

Status: VALIDATED

Source sequence(s)

AC123817

Consensus CDS

CCDS23251.1

UniProtKB/Swiss-Prot

Q7TN33, Q8BJ35

Related

ENSMUSP00000034840.4, ENSMUST00000034840.10

Conserved Domains (4) summary

cd12632
Location:41 → 127

RRM1_CELF3_4_5_6; RNA recognition motif 1 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

cd12635
Location:133 → 213

RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

cd12639
Location:371 → 449

RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

TIGR01659
Location:295 → 457

sex-lethal; sex-lethal family splicing factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

59485587..59516316

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155375.1 → XP_036011268.1 CUGBP Elav-like family member 6 isoform X4

Conserved Domains (3) summary

TIGR01628
Location:32 → 275

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12639
Location:277 → 355

RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

cd12635
Location:18 → 98

RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
XM_036155376.1 → XP_036011269.1 CUGBP Elav-like family member 6 isoform X5

Conserved Domains (3) summary

TIGR01628
Location:32 → 257

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12639
Location:256 → 334

RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

cd12635
Location:18 → 98

RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
XM_036155377.1 → XP_036011270.1 CUGBP Elav-like family member 6 isoform X5

Conserved Domains (3) summary

TIGR01628
Location:32 → 257

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12639
Location:256 → 334

RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

cd12635
Location:18 → 98

RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
XM_006511545.2 → XP_006511608.1 CUGBP Elav-like family member 6 isoform X4

See identical proteins and their annotated locations for XP_006511608.1

Conserved Domains (3) summary

TIGR01628
Location:32 → 275

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12639
Location:277 → 355

RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

cd12635
Location:18 → 98

RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
XM_006511543.2 → XP_006511606.1 CUGBP Elav-like family member 6 isoform X4

See identical proteins and their annotated locations for XP_006511606.1

Conserved Domains (3) summary

TIGR01628
Location:32 → 275

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12639
Location:277 → 355

RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

cd12635
Location:18 → 98

RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
XM_017313681.2 → XP_017169170.1 CUGBP Elav-like family member 6 isoform X6

Conserved Domains (3) summary

TIGR01628
Location:8 → 251

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12639
Location:253 → 331

RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

cl17169
Location:1 → 74

RRM_SF; RNA recognition motif (RRM) superfamily
XM_011242834.2 → XP_011241136.1 CUGBP Elav-like family member 6 isoform X4

See identical proteins and their annotated locations for XP_011241136.1

Conserved Domains (3) summary

TIGR01628
Location:32 → 275

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12639
Location:277 → 355

RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

cd12635
Location:18 → 98

RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins