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Fam131b family with sequence similarity 131, member B [ Mus musculus (house mouse) ]

Gene ID: 76156, updated on 5-Mar-2024

Summary

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Official Symbol
Fam131bprovided by MGI
Official Full Name
family with sequence similarity 131, member Bprovided by MGI
Primary source
MGI:MGI:1923406
See related
Ensembl:ENSMUSG00000029861 AllianceGenome:MGI:1923406
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6330503C03Rik; 6530406I18Rik
Summary
Predicted to be located in cytosol and nucleoplasm. Orthologous to human FAM131B (family with sequence similarity 131 member B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 27.0), frontal lobe adult (RPKM 21.6) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Fam131b in Genome Data Viewer
Location:
6 B2.1; 6 20.6 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (42292239..42301574, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (42315305..42324640, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:42214909-42215092 Neighboring gene caspase 2 Neighboring gene chloride channel, voltage-sensitive 1 Neighboring gene predicted gene, 38797 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:42293816-42293969 Neighboring gene predicted gene, 24611 Neighboring gene zyxin Neighboring gene Eph receptor A1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Proteomic analysis of in vivo phosphorylated synaptic proteins. Collins MO, et al. J Biol Chem, 2005 Feb 18. PMID 15572359
  2. Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Trinidad JC, et al. Mol Cell Proteomics, 2006 May. PMID 16452087
  3. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein FAM131B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113327.2 → NP_001106798.1  protein FAM131B isoform b

    See identical proteins and their annotated locations for NP_001106798.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (b) lacks an alternate in-frame exon in the 5' coding region, compared to variant a. It encodes isoform b, which lacks an internal segment and is shorter, compared to isoform a.
    Source sequence(s)
    AK163654, BB339978, BY260739
    Consensus CDS
    CCDS51758.1
    UniProtKB/TrEMBL
    A4FUR1
    Related
    ENSMUSP00000031891.9, ENSMUST00000031891.15
    Conserved Domains (1) summary
    pfam15010
    Location:55 → 341
    FAM131; Putative cell signalling

  2. NM_001286584.1 → NP_001273513.1  protein FAM131B isoform c

    See identical proteins and their annotated locations for NP_001273513.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (c) uses an alternate splice site in the 5' terminal exon and initiates translation at a downstream start codon, compared to variant a. It encodes isoform c, which is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AK158869, BB339978, BY260739
    Consensus CDS
    CCDS71759.1
    UniProtKB/Swiss-Prot
    Q3TQE4, Q3TY60, Q9D390
    UniProtKB/TrEMBL
    A4FUR1
    Related
    ENSMUSP00000093670.4, ENSMUST00000095974.4
    Conserved Domains (1) summary
    pfam15010
    Location:39 → 325
    FAM131; Putative cell signalling

  3. NM_029528.5 → NP_083804.3  protein FAM131B isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK047763, AK163654, BB339978, BY260739
    Consensus CDS
    CCDS39472.2
    UniProtKB/TrEMBL
    A4FUR1, E9Q8P8
    Related
    ENSMUSP00000116779.2, ENSMUST00000143278.8
    Conserved Domains (1) summary
    pfam15010
    Location:67 → 353
    FAM131; Putative cell signalling

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    42292239..42301574 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506730.5 → XP_006506793.1  protein FAM131B isoform X1

    UniProtKB/TrEMBL
    A4FUR1
    Conserved Domains (1) summary
    pfam15010
    Location:68 → 354
    FAM131; Putative cell signalling
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TY60.1 GenPept UniProtKB/Swiss-Prot:Q3TY60

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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