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Faxc failed axon connections homolog [ Mus musculus (house mouse) ]

Gene ID: 76132, updated on 5-Mar-2024

Summary

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Official Symbol
Faxcprovided by MGI
Official Full Name
failed axon connections homologprovided by MGI
Primary source
MGI:MGI:1923382
See related
Ensembl:ENSMUSG00000028246 AllianceGenome:MGI:1923382
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6230409E13Rik
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm. Orthologous to human FAXC (failed axon connections homolog, metaxin like GST domain containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 2.9), whole brain E14.5 (RPKM 2.5) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 A3; 4 9.2 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (21930906..22001461)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (21930906..22001461)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930528A17 gene Neighboring gene STARR-seq mESC enhancer starr_09734 Neighboring gene PNN interacting serine/arginine-rich Neighboring gene coenzyme Q3 methyltransferase Neighboring gene STARR-seq mESC enhancer starr_09735 Neighboring gene STARR-seq mESC enhancer starr_09736 Neighboring gene WEE1 homolog 2 pseudogene Neighboring gene predicted gene, 42260

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
failed axon connections homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175234.4 → NP_780443.2  failed axon connections homolog

    See identical proteins and their annotated locations for NP_780443.2

    Status: VALIDATED

    Source sequence(s)
    AL772187, AL772278
    Consensus CDS
    CCDS51130.1
    UniProtKB/Swiss-Prot
    Q3UMF9
    Related
    ENSMUSP00000029908.8, ENSMUST00000029908.8
    Conserved Domains (2) summary
    cd03193
    Location:187 → 327
    GST_C_Metaxin; C-terminal, alpha helical domain of Metaxin and related proteins
    cd03080
    Location:99 → 172
    GST_N_Metaxin_like; GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    21930906..22001461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538340.4 → XP_006538403.1  failed axon connections homolog isoform X1

    Conserved Domains (2) summary
    pfam17171
    Location:142 → 205
    GST_C_6; Glutathione S-transferase, C-terminal domain
    pfam17172
    Location:2 → 91
    GST_N_4; Glutathione S-transferase N-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UMF9.1 GenPept UniProtKB/Swiss-Prot:Q3UMF9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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