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Las1l LAS1-like (S. cerevisiae) [ Mus musculus (house mouse) ]

Gene ID: 76130, updated on 11-Apr-2024

Summary

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Official Symbol
Las1lprovided by MGI
Official Full Name
LAS1-like (S. cerevisiae)provided by MGI
Primary source
MGI:MGI:1923380
See related
Ensembl:ENSMUSG00000057421 AllianceGenome:MGI:1923380
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810030A06Rik; 5830482G23Rik
Summary
Predicted to enable endonuclease activity. Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Predicted to be located in cytoplasm and nucleus. Predicted to be part of MLL1 complex and preribosome, large subunit precursor. Human ortholog(s) of this gene implicated in Wilson-Turner syndrome. Orthologous to human LAS1L (LAS1 like ribosome biogenesis factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 15.5), CNS E14 (RPKM 8.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Las1l in Genome Data Viewer
Location:
X C3; X 42.58 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (94963651..95000580, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (95920045..95956974, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700010D01 gene Neighboring gene zinc finger CCCH-type containing 12B Neighboring gene FGFR1 oncogene partner 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47575 Neighboring gene predicted gene, 41897 Neighboring gene eukaryotic translation initiation factor 4B pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional persistence of exonized mammalian-wide interspersed repeat elements (MIRs). Krull M, et al. Genome Res, 2007 Aug. PMID 17623809, Free PMC Article
  2. Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation. Fanis P, et al. Mol Cell Proteomics, 2012 Nov. PMID 22872859, Free PMC Article
  3. Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Apr 30. PMID 15449545
  4. Affinity purification strategies for proteomic analysis of transcription factor complexes. Giambruno R, et al. J Proteome Res, 2013 Sep 6. PMID 23937658, Free PMC Article
  5. RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity. Nitzsche A, et al. PLoS One, 2011 May 12. PMID 21589869, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Recruitment of the protein complex 5FMC to Zbp-89, a zinc-finger transcription factor, affects its sumoylation status and transactivation potential.[5FMC]
    Title: Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in maturation of 5.8S rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of LSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Las1 complex IEA
Inferred from Electronic Annotation
more info
  
part_of MLL1 complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ribosomal biogenesis protein LAS1L
Names
endoribonuclease LAS1L
protein LAS1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374717.1 → NP_001361646.1  ribosomal biogenesis protein LAS1L isoform 1

    Status: VALIDATED

    Source sequence(s)
    BX005184
    UniProtKB/Swiss-Prot
    A2BE28, A2BE30, Q6KAR5, Q8C742
    Related
    ENSMUSP00000109495.3, ENSMUST00000113864.3
    Conserved Domains (1) summary
    pfam04031
    Location:28 → 172
    Las1; Las1-like

  2. NM_152822.3 → NP_690035.2  ribosomal biogenesis protein LAS1L isoform 2

    See identical proteins and their annotated locations for NP_690035.2

    Status: VALIDATED

    Source sequence(s)
    BC141155, BM570808, BY059480
    Consensus CDS
    CCDS30287.1
    UniProtKB/Swiss-Prot
    A2BE28
    Related
    ENSMUSP00000078901.7, ENSMUST00000079987.13
    Conserved Domains (1) summary
    pfam04031
    Location:28 → 172
    Las1; Las1-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    94963651..95000580 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528336.2 → XP_006528399.1  ribosomal biogenesis protein LAS1L isoform X3

    Conserved Domains (1) summary
    pfam04031
    Location:28 → 172
    Las1; Las1-like

  2. XM_017318635.2 → XP_017174124.1  ribosomal biogenesis protein LAS1L isoform X2

    Conserved Domains (1) summary
    pfam04031
    Location:28 → 172
    Las1; Las1-like

  3. XM_006528335.4 → XP_006528398.1  ribosomal biogenesis protein LAS1L isoform X1

    Conserved Domains (1) summary
    pfam04031
    Location:28 → 172
    Las1; Las1-like

RNA

  1. XR_878109.1 RNA Sequence

  2. XR_878108.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2BE28.1 GenPept UniProtKB/Swiss-Prot:A2BE28

Gene LinkOut

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