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Dock8 dedicator of cytokinesis 8 [ Mus musculus (house mouse) ]

Gene ID: 76088, updated on 21-Apr-2024

Summary

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Official Symbol
Dock8provided by MGI
Official Full Name
dedicator of cytokinesis 8provided by MGI
Primary source
MGI:MGI:1921396
See related
Ensembl:ENSMUSG00000052085 AllianceGenome:MGI:1921396
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1200017A24Rik; 5830472H07Rik; A130095G14Rik
Summary
Enables guanyl-nucleotide exchange factor activity. Involved in dendritic cell migration; positive regulation of T cell migration; and positive regulation of establishment of T cell polarity. Acts upstream of or within immunological synapse formation and negative regulation of T cell apoptotic process. Located in cell leading edge. Is expressed in central nervous system; retina; and thymus primordium. Human ortholog(s) of this gene implicated in atopic dermatitis; bacterial infectious disease; hyper IgE recurrent infection syndrome 2; immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome; and viral infectious disease (multiple). Orthologous to human DOCK8 (dedicator of cytokinesis 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 25.8), spleen adult (RPKM 17.9) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 B; 19 19.91 cM
Exon count:
52
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (24976753..25179796)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (24999321..25202432)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_45808 Neighboring gene forkhead box D4 Neighboring gene STARR-positive B cell enhancer mm9_chr19:25033055-25033356 Neighboring gene STARR-positive B cell enhancer ABC_E7639 Neighboring gene microRNA 3084-1 Neighboring gene STARR-positive B cell enhancer ABC_E5693 Neighboring gene Zn regulated GTPase metalloprotein activator 1 Neighboring gene STARR-seq mESC enhancer starr_45809 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:25126893-25127076 Neighboring gene STARR-positive B cell enhancer ABC_E1974 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4B Neighboring gene predicted gene, 34235 Neighboring gene STARR-seq mESC enhancer starr_45812 Neighboring gene predicted gene, 34186 Neighboring gene predicted gene, 24252 Neighboring gene STARR-seq mESC enhancer starr_45817 Neighboring gene KN motif and ankyrin repeat domains 1 Neighboring gene STARR-seq mESC enhancer starr_45819 Neighboring gene predicted gene, 34432 Neighboring gene predicted gene, 52392

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. IL-21 Rescues the Defect of IL-10-Producing Regulatory B Cells and Improves Allergic Asthma in DOCK8 Deficient Mice. Jiang J, et al. Front Immunol, 2021. PMID 34867940, Free PMC Article
  2. Cutting Edge: DOCK8 Regulates a Subset of Dendritic Cells That Is Critical for the Development of Experimental Autoimmune Encephalomyelitis. Weliwitigoda A, et al. J Immunol, 2021 Nov 15. PMID 34663621, Free PMC Article
  3. DOCK8 deficiency causes a skewing to type 2 immunity in the gut with expansion of group 2 innate lymphoid cells. Matsubara K, et al. Biochem Biophys Res Commun, 2021 Jun 25. PMID 33940384
  4. DOCK8 Expression in Regulatory T Cells Maintains their Stability and Limits Contact Hypersensitivity. Wilkie H, et al. J Invest Dermatol, 2021 Jun. PMID 33171169, Free PMC Article
  5. DOCK8 controls survival of group 3 innate lymphoid cells in the gut through Cdc42 activation. Aihara R, et al. Int Immunol, 2021 Mar 1. PMID 32986079

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MYD88L265P augments proximal B-cell receptor signaling in large B-cell lymphomas via an interaction with DOCK8.
    Title: MYD88L265P augments proximal B-cell receptor signaling in large B-cell lymphomas via an interaction with DOCK8.
  2. DOCK8 is essential for neutrophil mediated clearance of cutaneous S. aureus infection.
    Title: DOCK8 is essential for neutrophil mediated clearance of cutaneous S. aureus infection.
  3. IL-21 Rescues the Defect of IL-10-Producing Regulatory B Cells and Improves Allergic Asthma in DOCK8 Deficient Mice.
    Title: IL-21 Rescues the Defect of IL-10-Producing Regulatory B Cells and Improves Allergic Asthma in DOCK8 Deficient Mice.
  4. Cutting Edge: DOCK8 Regulates a Subset of Dendritic Cells That Is Critical for the Development of Experimental Autoimmune Encephalomyelitis.
    Title: Cutting Edge: DOCK8 Regulates a Subset of Dendritic Cells That Is Critical for the Development of Experimental Autoimmune Encephalomyelitis.
  5. DOCK8 Expression in Regulatory T Cells Maintains their Stability and Limits Contact Hypersensitivity.
    Title: DOCK8 Expression in Regulatory T Cells Maintains their Stability and Limits Contact Hypersensitivity.
  6. DOCK8 deficiency causes a skewing to type 2 immunity in the gut with expansion of group 2 innate lymphoid cells.
    Title: DOCK8 deficiency causes a skewing to type 2 immunity in the gut with expansion of group 2 innate lymphoid cells.
  7. Our studies reveal the novel finding that DOCK8 mutant mice, in contrast to the findings in humans, have elevated Th17 cells. Despite this, they do not get exaggerated EAE but appear protected due to a Th17 specific migration defect to the CNS.
    Title: Protection from EAE in DOCK8 mutant mice occurs despite increased Th17 cell frequencies in the periphery.
  8. The DOCK8 is expressed in microglia and regulates microglial activity in disease states.
    Title: DOCK8 is expressed in microglia, and it regulates microglial activity during neurodegeneration in murine disease models.
  9. DOCK8 and WASp are in the same signaling pathway that links T-cell receptors (TCRs) to the actin cytoskeleton in TCR-driven actin assembly.
    Title: A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton.
  10. LRCH1 as a novel effector to restrain PKCalpha-DOCK8-Cdc42 module-induced T cell migration and ameliorate experimental autoimmune encephalomyelitis (EAE).
    Title: LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to chemokine ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within dendritic cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within dendritic cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dendritic cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within immunological synapse formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within memory T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of T cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of T cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of T cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of establishment of T cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of establishment of T cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of establishment of T cell polarity ISO
Inferred from Sequence Orthology
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cell leading edge IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell leading edge IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in leading edge membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dedicator of cytokinesis protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028785.3 → NP_083061.2  dedicator of cytokinesis protein 8

    See identical proteins and their annotated locations for NP_083061.2

    Status: VALIDATED

    Source sequence(s)
    AK028968, AK038285, AK050543, AK131180, DT909592
    Consensus CDS
    CCDS37943.1
    UniProtKB/Swiss-Prot
    Q6KAM7, Q6PIS0, Q7TMQ5, Q8C147, Q8CAP6, Q8K105, Q9DBQ2
    UniProtKB/TrEMBL
    B9EJ70
    Related
    ENSMUSP00000025831.7, ENSMUST00000025831.8
    Conserved Domains (3) summary
    cd08696
    Location:560 → 740
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11701
    Location:1637 → 2058
    DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8
    pfam11878
    Location:73 → 164
    DUF3398; Domain of unknown function (DUF3398)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    24976753..25179796
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527436.5 → XP_006527499.1  dedicator of cytokinesis protein 8 isoform X2

    Conserved Domains (2) summary
    cd08696
    Location:560 → 740
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    pfam11878
    Location:56 → 166
    DUF3398; Domain of unknown function (DUF3398)

  2. XM_011247397.4 → XP_011245699.1  dedicator of cytokinesis protein 8 isoform X1

    See identical proteins and their annotated locations for XP_011245699.1

    UniProtKB/TrEMBL
    B9EJ70
    Conserved Domains (3) summary
    cd08696
    Location:492 → 672
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11701
    Location:1569 → 1990
    DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8
    pfam11878
    Location:1 → 98
    DUF3398; Domain of unknown function (DUF3398)

  3. XM_006527435.3 → XP_006527498.1  dedicator of cytokinesis protein 8 isoform X1

    See identical proteins and their annotated locations for XP_006527498.1

    UniProtKB/TrEMBL
    B9EJ70
    Conserved Domains (3) summary
    cd08696
    Location:492 → 672
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11701
    Location:1569 → 1990
    DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8
    pfam11878
    Location:1 → 98
    DUF3398; Domain of unknown function (DUF3398)

RNA

  1. XR_004940182.1 RNA Sequence

  2. XR_004940183.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_175233.3: Suppressed sequence

    Description
    NM_175233.3: This RefSeq was temporarily suppressed because currently there are not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C147.4 GenPept UniProtKB/Swiss-Prot:Q8C147

Gene LinkOut

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