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Gbp8 guanylate-binding protein 8 [ Mus musculus (house mouse) ]

Gene ID: 76074, updated on 8-Feb-2024

Summary

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Official Symbol
Gbp8provided by MGI
Official Full Name
guanylate-binding protein 8provided by MGI
Primary source
MGI:MGI:1923324
See related
Ensembl:ENSMUSG00000034438 AllianceGenome:MGI:1923324
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mGBP8; 5830443L24Rik
Summary
Predicted to enable GTP binding activity and GTPase activity. Acts upstream of or within cellular response to interferon-gamma. Predicted to be active in cytoplasmic vesicle. Orthologous to human GBP6 (guanylate binding protein family member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 14.5), spleen adult (RPKM 2.9) and 7 other tissues See more
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Genomic context

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Location:
5 E5; 5 50.68 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (105160379..105201475, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (105012513..105053609, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24097 Neighboring gene ATP binding cassette subfamily G member 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:105411589-105411825 Neighboring gene STARR-seq mESC enhancer starr_13846 Neighboring gene Sec61 beta subunit pseudogene Neighboring gene STARR-seq mESC enhancer starr_13847 Neighboring gene guanylate-binding protein 9 Neighboring gene STARR-positive B cell enhancer ABC_E1304 Neighboring gene guanylate binding protein 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense. Degrandi D, et al. J Immunol, 2007 Dec 1. PMID 18025219
  2. Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway. Simpson DS, et al. Immunity, 2022 Mar 8. PMID 35139355, Free PMC Article
  3. A family of IFN-γ-inducible 65-kD GTPases protects against bacterial infection. Kim BH, et al. Science, 2011 May 6. PMID 21551061
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to type II interferon IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to type II interferon IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to protozoan IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
guanylate binding protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029509.4 → NP_083785.3  guanylate binding protein 8

    See identical proteins and their annotated locations for NP_083785.3

    Status: VALIDATED

    Source sequence(s)
    AC144914, BY089370, DQ295175
    Consensus CDS
    CCDS19490.1
    UniProtKB/TrEMBL
    F7CE50, Q2V6D6
    Related
    ENSMUSP00000031235.7, ENSMUST00000031235.13
    Conserved Domains (2) summary
    pfam02841
    Location:206 → 493
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl38936
    Location:16 → 207
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    105160379..105201475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535283.2 → XP_006535346.1  guanylate binding protein 8 isoform X4

    Conserved Domains (2) summary
    pfam02841
    Location:63 → 348
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl38936
    Location:16 → 62
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_011249593.1 → XP_011247895.1  guanylate binding protein 8 isoform X5

    Conserved Domains (2) summary
    pfam02263
    Location:16 → 280
    GBP; Guanylate-binding protein, N-terminal domain
    pfam02841
    Location:282 → 576
    GBP_C; Guanylate-binding protein, C-terminal domain

  3. XM_017321140.2 → XP_017176629.1  guanylate binding protein 8 isoform X2

    Conserved Domains (2) summary
    pfam02841
    Location:129 → 416
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl38936
    Location:1 → 130
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. XM_017321142.3 → XP_017176631.1  guanylate binding protein 8 isoform X3

    UniProtKB/TrEMBL
    Q66K09
    Conserved Domains (2) summary
    pfam02841
    Location:78 → 365
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl38936
    Location:1 → 79
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  5. XM_017321141.3 → XP_017176630.1  guanylate binding protein 8 isoform X3

    UniProtKB/TrEMBL
    Q66K09
    Conserved Domains (2) summary
    pfam02841
    Location:78 → 365
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl38936
    Location:1 → 79
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  6. XM_006535281.5 → XP_006535344.1  guanylate binding protein 8 isoform X1

    See identical proteins and their annotated locations for XP_006535344.1

    UniProtKB/TrEMBL
    F7CE50, Q2V6D6
    Conserved Domains (2) summary
    pfam02841
    Location:206 → 493
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl38936
    Location:16 → 207
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

  1. XR_389295.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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