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Pcgf5 polycomb group ring finger 5 [ Mus musculus (house mouse) ]

Gene ID: 76073, updated on 5-Mar-2024

Summary

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Official Symbol
Pcgf5provided by MGI
Official Full Name
polycomb group ring finger 5provided by MGI
Primary source
MGI:MGI:1923505
See related
Ensembl:ENSMUSG00000024805 AllianceGenome:MGI:1923505
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610009F02Rik; 1110054A01Rik; 5830406C17Rik; 5830443C21Rik; 9530023M17Rik
Summary
Predicted to enable metal ion binding activity. Involved in histone H2A-K119 monoubiquitination and inactivation of X chromosome by genetic imprinting. Part of PcG protein complex. Colocalizes with X chromosome. Is expressed in bladder; heart; and ureter. Orthologous to human PCGF5 (polycomb group ring finger 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 8.9), heart adult (RPKM 3.9) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 C2; 19 31.59 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (36325729..36438370)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (36348329..36460970)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32027 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:36316959-36317171 Neighboring gene predicted gene, 46664 Neighboring gene predicted gene, 57659 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 9 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:36459071-36459224 Neighboring gene IK cytokine pseudogene Neighboring gene STARR-seq mESC enhancer starr_46024 Neighboring gene STARR-seq mESC enhancer starr_46026 Neighboring gene predicted gene, 32143 Neighboring gene predicted gene, 41838

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Polycomb group RING finger protein 5 influences several developmental signaling pathways during the in vitro differentiation of mouse embryonic stem cells. Meng Y, et al. Dev Growth Differ, 2020 May. PMID 32130724
  2. PCGF5 is required for neural differentiation of embryonic stem cells. Yao M, et al. Nat Commun, 2018 May 15. PMID 29765032, Free PMC Article
  3. Polycomb group RING finger proteins 3/5 activate transcription via an interaction with the pluripotency factor Tex10 in embryonic stem cells. Zhao W, et al. J Biol Chem, 2017 Dec 29. PMID 29054931, Free PMC Article
  4. Loss of Pcgf5 Affects Global H2A Monoubiquitination but Not the Function of Hematopoietic Stem and Progenitor Cells. Si S, et al. PLoS One, 2016. PMID 27136092, Free PMC Article
  5. Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression. Fursova NA, et al. Mol Cell, 2019 Jun 6. PMID 31029541, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Polycomb group RING finger protein 5 influences several developmental signaling pathways during the in vitro differentiation of mouse embryonic stem cells.
    Title: Polycomb group RING finger protein 5 influences several developmental signaling pathways during the in vitro differentiation of mouse embryonic stem cells.
  2. the knockout of Pcgf3, Pcgf5, or both resulted in a 39, 29, and 52% decrease, respectively, in global levels of H2AK119ub1 as compared with wild-type cells, as evidenced by Western blotting. In contrast, no similar change was observed for H3K27me3.
    Title: Polycomb group RING finger proteins 3/5 activate transcription via an interaction with the pluripotency factor Tex10 in embryonic stem cells.
  3. Although PCGF5 is not required for embryonic stem cell (ESC) self-renewal, its loss blocks ESC neural differentiation by activating the SMAD2/TGF-beta signaling pathway.
    Title: PCGF5 is required for neural differentiation of embryonic stem cells.
  4. Authors conclude that RYBP/YAF2 binding to H2AK119u1 likely underpins the transient interaction of noncanonical PRC1 complexes with Xist RNA domains but does not account for stable interaction of PCGF3/5-PRC1 complexes.
    Title: PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation.
  5. hnRNPK recruits PCGF3/5-PRC1 to the Xist RNA B-repeat to establish polycomb-mediated chromosomal silencing.
    Title: hnRNPK Recruits PCGF3/5-PRC1 to the Xist RNA B-Repeat to Establish Polycomb-Mediated Chromosomal Silencing.
  6. findings demonstrate that Pcgf5-containing PRC1 functions as a histone modifier in vivo, but its role in HSPCs is limited and can be compensated by other PRC1-related complexes in HSPCs.
    Title: Loss of Pcgf5 Affects Global H2A Monoubiquitination but Not the Function of Hematopoietic Stem and Progenitor Cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone H2AK119 ubiquitin ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in random inactivation of X chromosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of PRC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of PcG protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of PcG protein complex ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with X chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
polycomb group RING finger protein 5
Names
RING finger protein 159

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368690.1 → NP_001355619.1  polycomb group RING finger protein 5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC117769
    Consensus CDS
    CCDS89384.1
    UniProtKB/Swiss-Prot
    B2RTD3, B7ZP23, Q3UK78, Q9D3E5, Q9DCW8
    UniProtKB/TrEMBL
    B7ZP24
    Conserved Domains (3) summary
    TIGR00599
    Location:8 → 135
    rad18; DNA repair protein rad18
    cd16737
    Location:16 → 57
    RING-HC_PCGF5; RING finger found in polycomb group RING finger protein 5 (PCGF5) and similar proteins
    cd17084
    Location:136 → 256
    RAWUL_PCGF5; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 5 (PCGF5) and similar proteins

  2. NM_001368691.1 → NP_001355620.1  polycomb group RING finger protein 5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC117769
    Consensus CDS
    CCDS89384.1
    UniProtKB/Swiss-Prot
    B2RTD3, B7ZP23, Q3UK78, Q9D3E5, Q9DCW8
    UniProtKB/TrEMBL
    B7ZP24
    Related
    ENSMUSP00000153464.2, ENSMUST00000225411.2
    Conserved Domains (3) summary
    TIGR00599
    Location:8 → 135
    rad18; DNA repair protein rad18
    cd16737
    Location:16 → 57
    RING-HC_PCGF5; RING finger found in polycomb group RING finger protein 5 (PCGF5) and similar proteins
    cd17084
    Location:136 → 256
    RAWUL_PCGF5; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 5 (PCGF5) and similar proteins

  3. NM_001368692.1 → NP_001355621.1  polycomb group RING finger protein 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AA472895, AC117769, AK002387, AK004240, CX224153
    Consensus CDS
    CCDS29772.1
    UniProtKB/TrEMBL
    B7ZP24
    Related
    ENSMUSP00000153206.2, ENSMUST00000225920.2
    Conserved Domains (3) summary
    TIGR00599
    Location:8 → 135
    rad18; DNA repair protein rad18
    cd16737
    Location:16 → 57
    RING-HC_PCGF5; RING finger found in polycomb group RING finger protein 5 (PCGF5) and similar proteins
    cd17084
    Location:136 → 236
    RAWUL_PCGF5; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 5 (PCGF5) and similar proteins

  4. NM_001368693.1 → NP_001355622.1  polycomb group RING finger protein 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC117769
    Consensus CDS
    CCDS29772.1
    UniProtKB/TrEMBL
    B7ZP24
    Related
    ENSMUSP00000058730.6, ENSMUST00000062389.6
    Conserved Domains (3) summary
    TIGR00599
    Location:8 → 135
    rad18; DNA repair protein rad18
    cd16737
    Location:16 → 57
    RING-HC_PCGF5; RING finger found in polycomb group RING finger protein 5 (PCGF5) and similar proteins
    cd17084
    Location:136 → 236
    RAWUL_PCGF5; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 5 (PCGF5) and similar proteins

  5. NM_029508.4 → NP_083784.1  polycomb group RING finger protein 5 isoform 2

    See identical proteins and their annotated locations for NP_083784.1

    Status: VALIDATED

    Source sequence(s)
    AC117769
    Consensus CDS
    CCDS29772.1
    UniProtKB/TrEMBL
    B7ZP24
    Related
    ENSMUSP00000071245.7, ENSMUST00000071267.14
    Conserved Domains (3) summary
    TIGR00599
    Location:8 → 135
    rad18; DNA repair protein rad18
    cd16737
    Location:16 → 57
    RING-HC_PCGF5; RING finger found in polycomb group RING finger protein 5 (PCGF5) and similar proteins
    cd17084
    Location:136 → 236
    RAWUL_PCGF5; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 5 (PCGF5) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    36325729..36438370
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161722.1 → XP_036017615.1  polycomb group RING finger protein 5 isoform X2

    UniProtKB/TrEMBL
    B7ZP24
    Conserved Domains (3) summary
    TIGR00599
    Location:8 → 135
    rad18; DNA repair protein rad18
    cd16737
    Location:16 → 57
    RING-HC_PCGF5; RING finger found in polycomb group RING finger protein 5 (PCGF5) and similar proteins
    cd17084
    Location:136 → 236
    RAWUL_PCGF5; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 5 (PCGF5) and similar proteins

  2. XM_011247392.4 → XP_011245694.1  polycomb group RING finger protein 5 isoform X1

    See identical proteins and their annotated locations for XP_011245694.1

    UniProtKB/Swiss-Prot
    B2RTD3, B7ZP23, Q3UK78, Q9D3E5, Q9DCW8
    UniProtKB/TrEMBL
    B7ZP24
    Conserved Domains (3) summary
    TIGR00599
    Location:8 → 135
    rad18; DNA repair protein rad18
    cd16737
    Location:16 → 57
    RING-HC_PCGF5; RING finger found in polycomb group RING finger protein 5 (PCGF5) and similar proteins
    cd17084
    Location:136 → 256
    RAWUL_PCGF5; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 5 (PCGF5) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UK78.1 GenPept UniProtKB/Swiss-Prot:Q3UK78

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