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Jakmip1 janus kinase and microtubule interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 76071, updated on 21-Apr-2024

Summary

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Official Symbol
Jakmip1provided by MGI
Official Full Name
janus kinase and microtubule interacting protein 1provided by MGI
Primary source
MGI:MGI:1923321
See related
Ensembl:ENSMUSG00000063646 AllianceGenome:MGI:1923321
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gababrbp; Marlin-1; 5830437M04Rik; C330021K24Rik
Summary
Enables kinesin binding activity. Predicted to be involved in cognition. Predicted to act upstream of or within protein transport. Predicted to be located in microtubule cytoskeleton. Predicted to be extrinsic component of membrane. Predicted to be part of ribonucleoprotein complex. Is expressed in embryo. Used to study autism spectrum disorder. Orthologous to human JAKMIP1 (janus kinase and microtubule interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 6.5), CNS E18 (RPKM 6.0) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 B3; 5 19.66 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (37182424..37307958)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (37025852..37150614)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2, regulatory subunit B, gamma Neighboring gene STARR-seq mESC enhancer starr_12890 Neighboring gene predicted gene, 52813 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:37370903-37371090 Neighboring gene STARR-positive B cell enhancer ABC_E6324 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:37380607-37380790 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:37389242-37389505 Neighboring gene STARR-seq mESC enhancer starr_12893 Neighboring gene wolframin ER transmembrane glycoprotein Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:37436048-37436298 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:37438571-37438789 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:37442129-37442330 Neighboring gene STARR-seq mESC enhancer starr_12898 Neighboring gene isocitrate dehydrogenase 3 (NAD+) beta pseudogene Neighboring gene predicted gene 1043 Neighboring gene STARR-seq mESC enhancer starr_12900 Neighboring gene collapsin response mediator protein 1 Neighboring gene EvC ciliary complex subunit 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cellular and subcellular localization of Marlin-1 in the brain. Vidal RL, et al. BMC Neurosci, 2009 Apr 22. PMID 19386132, Free PMC Article
  2. Identification and expression analysis of novel Jakmip1 transcripts. Costa V, et al. Gene, 2007 Nov 1. PMID 17761393
  3. Marlin-1, a novel RNA-binding protein associates with GABA receptors. Couve A, et al. J Biol Chem, 2004 Apr 2. PMID 14718537
  4. Marlin-1 and conventional kinesin link GABAB receptors to the cytoskeleton and regulate receptor transport. Vidal RL, et al. Mol Cell Neurosci, 2007 Jul. PMID 17532644
  5. JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse. Berg JM, et al. Neuron, 2015 Dec 16. PMID 26627310, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GABA receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GABA receptor binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables kinesin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cognition ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
janus kinase and microtubule-interacting protein 1
Names
GABA-B receptor-binding protein
gamma-aminobutyric acid (GABA-B) receptor binding protein
multiple alpha-helices and RNA-linker protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347348.2 → NP_001334277.1  janus kinase and microtubule-interacting protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC110238, AC115722
    Conserved Domains (2) summary
    TIGR02169
    Location:56 → 363
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam16034
    Location:415 → 612
    JAKMIP_CC3; JAKMIP CC3 domain

  2. NM_001401053.1 → NP_001387982.1  janus kinase and microtubule-interacting protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC110238, AC115722

  3. NM_001401054.1 → NP_001387983.1  janus kinase and microtubule-interacting protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC110238, AC115722

  4. NM_001401055.1 → NP_001387984.1  janus kinase and microtubule-interacting protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC110238, AC115722
    UniProtKB/TrEMBL
    D3Z4U5
    Related
    ENSMUSP00000113624.3, ENSMUST00000121010.9

  5. NM_001401056.1 → NP_001387985.1  janus kinase and microtubule-interacting protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC110238, AC115722

  6. NM_178394.4 → NP_848481.2  janus kinase and microtubule-interacting protein 1 isoform 2

    See identical proteins and their annotated locations for NP_848481.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK077298, BC138649, BM900067, BY092450
    Consensus CDS
    CCDS19246.1
    UniProtKB/Swiss-Prot
    B2RS01, Q8BVL9
    Related
    ENSMUSP00000038504.5, ENSMUST00000043794.11
    Conserved Domains (2) summary
    TIGR02169
    Location:56 → 363
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam16034
    Location:415 → 604
    JAKMIP_CC3; JAKMIP CC3 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    37182424..37307958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240784.4 → XP_011239086.1  janus kinase and microtubule-interacting protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011239086.1

    Conserved Domains (2) summary
    TIGR02169
    Location:56 → 363
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam16034
    Location:415 → 612
    JAKMIP_CC3; JAKMIP CC3 domain

  2. XM_011240789.4 → XP_011239091.1  janus kinase and microtubule-interacting protein 1 isoform X2

    Conserved Domains (2) summary
    TIGR02169
    Location:56 → 363
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam16034
    Location:415 → 612
    JAKMIP_CC3; JAKMIP CC3 domain

  3. XM_036165590.1 → XP_036021483.1  janus kinase and microtubule-interacting protein 1 isoform X7

    Conserved Domains (2) summary
    TIGR02169
    Location:6 → 363
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam16034
    Location:416 → 612
    JAKMIP_CC3; JAKMIP CC3 domain

  4. XM_011240791.4 → XP_011239093.1  janus kinase and microtubule-interacting protein 1 isoform X8

    Conserved Domains (3) summary
    TIGR02168
    Location:473 → 779
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:56 → 363
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam16034
    Location:415 → 612
    JAKMIP_CC3; JAKMIP CC3 domain

  5. XM_011240788.4 → XP_011239090.1  janus kinase and microtubule-interacting protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011239090.1

    Conserved Domains (2) summary
    TIGR02169
    Location:56 → 363
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam16034
    Location:415 → 612
    JAKMIP_CC3; JAKMIP CC3 domain

  6. XM_017321139.3 → XP_017176628.1  janus kinase and microtubule-interacting protein 1 isoform X9

    UniProtKB/Swiss-Prot
    B2RS01, Q8BVL9
    Conserved Domains (2) summary
    TIGR02169
    Location:56 → 363
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam16034
    Location:415 → 604
    JAKMIP_CC3; JAKMIP CC3 domain

  7. XM_011240787.4 → XP_011239089.1  janus kinase and microtubule-interacting protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011239089.1

    Conserved Domains (2) summary
    TIGR02169
    Location:56 → 363
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam16034
    Location:415 → 612
    JAKMIP_CC3; JAKMIP CC3 domain

  8. XM_011240786.4 → XP_011239088.1  janus kinase and microtubule-interacting protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011239088.1

    Conserved Domains (2) summary
    TIGR02169
    Location:56 → 363
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam16034
    Location:415 → 612
    JAKMIP_CC3; JAKMIP CC3 domain

  9. XM_017321138.3 → XP_017176627.1  janus kinase and microtubule-interacting protein 1 isoform X1

    Conserved Domains (2) summary
    TIGR02169
    Location:56 → 363
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam16034
    Location:415 → 612
    JAKMIP_CC3; JAKMIP CC3 domain

  10. XM_017321137.3 → XP_017176626.1  janus kinase and microtubule-interacting protein 1 isoform X1

    Conserved Domains (2) summary
    TIGR02169
    Location:56 → 363
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam16034
    Location:415 → 612
    JAKMIP_CC3; JAKMIP CC3 domain

  11. XM_011240785.3 → XP_011239087.1  janus kinase and microtubule-interacting protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011239087.1

    Conserved Domains (2) summary
    TIGR02169
    Location:56 → 363
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam16034
    Location:415 → 612
    JAKMIP_CC3; JAKMIP CC3 domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BVL9.2 GenPept UniProtKB/Swiss-Prot:Q8BVL9

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