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Ccdc125 coiled-coil domain containing 125 [ Mus musculus (house mouse) ]

Gene ID: 76041, updated on 30-Apr-2024

Summary

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Official Symbol
Ccdc125provided by MGI
Official Full Name
coiled-coil domain containing 125provided by MGI
Primary source
MGI:MGI:1923291
See related
Ensembl:ENSMUSG00000048924 AllianceGenome:MGI:1923291
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5830436D01Rik
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in activation of GTPase activity; negative regulation of Rho protein signal transduction; and negative regulation of cell motility. Predicted to be active in cytoplasm. Orthologous to human CCDC125 (coiled-coil domain containing 125). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E18 (RPKM 2.6), bladder adult (RPKM 2.3) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 D1; 13 53.23 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (100805442..100833748)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (100668934..100697240)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RAD17 checkpoint clamp loader component Neighboring gene STARR-positive B cell enhancer ABC_E7268 Neighboring gene TATA-box binding protein associated factor 9 Neighboring gene adenylate kinase 6 Neighboring gene STARR-seq mESC enhancer starr_35476 Neighboring gene cyclin dependent kinase 7 Neighboring gene STARR-seq mESC enhancer starr_35477 Neighboring gene STARR-positive B cell enhancer ABC_E7269 Neighboring gene STARR-positive B cell enhancer mm9_chr13:101513935-101514236 Neighboring gene mitochondrial ribosomal protein S36 Neighboring gene centromere protein H

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Role of Kenae/CCDC125 in cell motility through the deregulation of RhoGTPase. Araya N, et al. Int J Mol Med, 2009 Nov. PMID 19787194
  2. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell motility ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell motility IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
coiled-coil domain-containing protein 125

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168386.2 → NP_001161858.1  coiled-coil domain-containing protein 125 isoform B

    See identical proteins and their annotated locations for NP_001161858.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (B) lacks an in-frame exon in the 5' coding region and an exon in the 3' coding region, which results in a frameshift, compared to variant A. The resulting protein (isoform B) is shorter and has a distinct C-terminus, compared to isoform A.
    Source sequence(s)
    AC165159, AK017973
    Consensus CDS
    CCDS49346.1
    UniProtKB/TrEMBL
    G3UWA1
    Related
    ENSMUSP00000130107.3, ENSMUST00000170347.4
    Conserved Domains (1) summary
    COG1196
    Location:105 → 226
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. NM_183115.5 → NP_898938.4  coiled-coil domain-containing protein 125 isoform A

    See identical proteins and their annotated locations for NP_898938.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A) represents the longer transcript and encodes the longer isoform (A).
    Source sequence(s)
    AC165159
    Consensus CDS
    CCDS26736.1
    UniProtKB/Swiss-Prot
    E9QPT5, Q5U465, Q8CEN7
    Related
    ENSMUSP00000058484.8, ENSMUST00000057325.15
    Conserved Domains (1) summary
    COG1196
    Location:83 → 429
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    100805442..100833748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244703.3 → XP_011243005.1  coiled-coil domain-containing protein 125 isoform X2

    See identical proteins and their annotated locations for XP_011243005.1

    UniProtKB/Swiss-Prot
    E9QPT5, Q5U465, Q8CEN7
    Conserved Domains (1) summary
    COG1196
    Location:83 → 429
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. XM_017315630.2 → XP_017171119.2  coiled-coil domain-containing protein 125 isoform X1

    Conserved Domains (1) summary
    COG1196
    Location:116 → 462
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  3. XM_011244704.1 → XP_011243006.1  coiled-coil domain-containing protein 125 isoform X2

    See identical proteins and their annotated locations for XP_011243006.1

    UniProtKB/Swiss-Prot
    E9QPT5, Q5U465, Q8CEN7
    Conserved Domains (1) summary
    COG1196
    Location:83 → 429
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  4. XM_011244705.1 → XP_011243007.1  coiled-coil domain-containing protein 125 isoform X2

    See identical proteins and their annotated locations for XP_011243007.1

    UniProtKB/Swiss-Prot
    E9QPT5, Q5U465, Q8CEN7
    Conserved Domains (1) summary
    COG1196
    Location:83 → 429
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  5. XM_036158215.1 → XP_036014108.1  coiled-coil domain-containing protein 125 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U465.2 GenPept UniProtKB/Swiss-Prot:Q5U465

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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