U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gon4l gon-4 like [ Mus musculus (house mouse) ]

Gene ID: 76022, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Gon4lprovided by MGI
Official Full Name
gon-4 likeprovided by MGI
Primary source
MGI:MGI:1917579
See related
Ensembl:ENSMUSG00000054199 AllianceGenome:MGI:1917579
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AA387005; 1500041I23Rik; 2610100B20Rik; 3632445O20Rik; 5430404N14Rik
Summary
Enables transcription corepressor activity. Involved in negative regulation of transcription, DNA-templated. Acts upstream of or within B cell differentiation. Located in nucleus. Used to study salivary gland cancer. Orthologous to several human genes including GON4L (gon-4 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 18.1), CNS E14 (RPKM 12.6) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
3 F1; 3 39.0 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (88742531..88817406)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88835207..88910099)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4551 Neighboring gene gon-4-like pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3444 Neighboring gene synaptotagmin XI Neighboring gene STARR-seq mESC enhancer starr_08218 Neighboring gene RIKEN cDNA 1500004A13 gene Neighboring gene STARR-seq mESC enhancer starr_08219 Neighboring gene STARR-positive B cell enhancer ABC_E10195 Neighboring gene STARR-seq mESC enhancer starr_08220 Neighboring gene predicted gene, 23054 Neighboring gene STARR-seq mESC enhancer starr_08221 Neighboring gene predicted gene, 40091 Neighboring gene predicted gene, 53242 Neighboring gene nuclear encoded rRNA 5S 197 Neighboring gene misato 1, mitochondrial distribution and morphology regulator Neighboring gene death associated protein 3 Neighboring gene ASH1 like histone lysine methyltransferase Neighboring gene predicted gene, 26465

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The transcriptional regulator GON4L is required for viability and hematopoiesis in mice. Colgan DF, et al. Exp Hematol, 2021 Jun. PMID 33864850, Free PMC Article
  2. Early B Cell Progenitors Deficient for GON4L Fail To Differentiate Due to a Block in Mitotic Cell Division. Barr JY, et al. J Immunol, 2017 May 15. PMID 28381640, Free PMC Article
  3. The Justy mutation identifies Gon4-like as a gene that is essential for B lymphopoiesis. Lu P, et al. J Exp Med, 2010 Jul 5. PMID 20530203, Free PMC Article
  4. The Justy mutant mouse strain produces a spontaneous murine model of salivary gland cancer with myoepithelial and basal cell differentiation. Simons AL, et al. Lab Invest, 2013 Jun. PMID 23608756, Free PMC Article
  5. The developmental regulator protein Gon4l associates with protein YY1, co-repressor Sin3a, and histone deacetylase 1 and mediates transcriptional repression. Lu P, et al. J Biol Chem, 2011 May 20. PMID 21454521, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The transcriptional regulator GON4L is required for viability and hematopoiesis in mice.
    Title: The transcriptional regulator GON4L is required for viability and hematopoiesis in mice.
  2. Newly identified Gon4l/Udu-interacting proteins implicate novel functions.
    Title: Newly identified Gon4l/Udu-interacting proteins implicate novel functions.
  3. findings indicate that GON4L is essential for cell cycle progression and division during the early stages of B cell development
    Title: Early B Cell Progenitors Deficient for GON4L Fail To Differentiate Due to a Block in Mitotic Cell Division.
  4. mice with recessive mutation spontaneously developed carcinomas with myoepithelial and basaloid differentiation in salivary glands with an incidence of approximately 25%
    Title: The Justy mutant mouse strain produces a spontaneous murine model of salivary gland cancer with myoepithelial and basal cell differentiation.
  5. the Gon4l protein is required for B lymphopoiesis and may function to regulate gene expression during this process.
    Title: The Justy mutation identifies Gon4-like as a gene that is essential for B lymphopoiesis.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Ino80 complex ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
GON-4-like protein
Names
GON-4 homolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242372.2 → NP_001229301.1  GON-4-like protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC127377
    UniProtKB/TrEMBL
    Q32NZ8
    Conserved Domains (2) summary
    cd12202
    Location:2161 → 2226
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain
    pfam02671
    Location:1671 → 1716
    PAH; Paired amphipathic helix repeat

  2. NM_001408383.1 → NP_001395312.1  GON-4-like protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC127377

  3. NM_027389.4 → NP_081665.2  GON-4-like protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC127377
    Consensus CDS
    CCDS50954.1
    UniProtKB/TrEMBL
    E9Q507, F8WGY9, Q32NZ8
    Related
    ENSMUSP00000103122.3, ENSMUST00000107498.9
    Conserved Domains (2) summary
    cd12202
    Location:2144 → 2209
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain
    pfam02671
    Location:1654 → 1699
    PAH; Paired amphipathic helix repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    88742531..88817406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163384.1 → XP_036019277.1  GON-4-like protein isoform X1

    UniProtKB/TrEMBL
    Q32NZ8
    Conserved Domains (3) summary
    cd12202
    Location:2163 → 2228
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain
    PHA03247
    Location:992 → 1258
    PHA03247; large tegument protein UL36; Provisional
    pfam02671
    Location:1672 → 1717
    PAH; Paired amphipathic helix repeat

  2. XM_036163387.1 → XP_036019280.1  GON-4-like protein isoform X4

    UniProtKB/TrEMBL
    Q32NZ8
    Conserved Domains (3) summary
    cd12202
    Location:2154 → 2219
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain
    PHA03247
    Location:983 → 1249
    PHA03247; large tegument protein UL36; Provisional
    pfam02671
    Location:1663 → 1708
    PAH; Paired amphipathic helix repeat

  3. XM_036163385.1 → XP_036019278.1  GON-4-like protein isoform X2

    UniProtKB/Swiss-Prot
    E9Q5N3, Q80TB4, Q91YI9, Q9DB00
    UniProtKB/TrEMBL
    Q32NZ8
    Related
    ENSMUSP00000080397.9, ENSMUST00000081695.15
    Conserved Domains (3) summary
    cd12202
    Location:2162 → 2227
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain
    PHA03247
    Location:992 → 1258
    PHA03247; large tegument protein UL36; Provisional
    pfam02671
    Location:1672 → 1717
    PAH; Paired amphipathic helix repeat

  4. XM_036163386.1 → XP_036019279.1  GON-4-like protein isoform X3

    UniProtKB/TrEMBL
    Q32NZ8
    Conserved Domains (3) summary
    cd12202
    Location:2154 → 2219
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain
    PHA03247
    Location:984 → 1250
    PHA03247; large tegument protein UL36; Provisional
    pfam02671
    Location:1664 → 1709
    PAH; Paired amphipathic helix repeat

  5. XM_036163388.1 → XP_036019281.1  GON-4-like protein isoform X5

    UniProtKB/TrEMBL
    Q32NZ8
    Conserved Domains (3) summary
    cd12202
    Location:2153 → 2218
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain
    PHA03247
    Location:983 → 1249
    PHA03247; large tegument protein UL36; Provisional
    pfam02671
    Location:1663 → 1708
    PAH; Paired amphipathic helix repeat

RNA

  1. XR_004941411.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DB00.3 GenPept UniProtKB/Swiss-Prot:Q9DB00

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous