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Slain2 SLAIN motif family, member 2 [ Mus musculus (house mouse) ]

Gene ID: 75991, updated on 5-Mar-2024

Summary

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Official Symbol
Slain2provided by MGI
Official Full Name
SLAIN motif family, member 2provided by MGI
Primary source
MGI:MGI:1923241
See related
Ensembl:ENSMUSG00000036087 AllianceGenome:MGI:1923241
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5033405K12Rik; 8030444K12Rik
Summary
Involved in cytoplasmic microtubule organization and regulation of microtubule polymerization. Predicted to be located in centrosome and cytosol. Predicted to colocalize with microtubule plus-end. Is expressed in several structures, including brain and liver lobe. Orthologous to human SLAIN2 (SLAIN motif family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 52.4), heart adult (RPKM 16.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 C3.2; 5 38.44 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (73071705..73136184)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (72914362..72978841)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3582 Neighboring gene TXK tyrosine kinase Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:73152561-73152781 Neighboring gene tec protein tyrosine kinase Neighboring gene STARR-positive B cell enhancer ABC_E4762 Neighboring gene STARR-positive B cell enhancer ABC_E8061 Neighboring gene STARR-positive B cell enhancer ABC_E10324 Neighboring gene STARR-positive B cell enhancer ABC_E8821 Neighboring gene predicted gene, 54302 Neighboring gene predicted gene, 54289 Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), member 4 Neighboring gene zygote arrest 1, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cardiac-specific elevations in thyroid hormone enhance contractility and prevent pressure overload-induced cardiac dysfunction. Trivieri MG, et al. Proc Natl Acad Sci U S A, 2006 Apr 11. PMID 16595628, Free PMC Article
  2. Microtubule plus-end tracking proteins SLAIN1/2 and ch-TOG promote axonal development. van der Vaart B, et al. J Neurosci, 2012 Oct 17. PMID 23077057, Free PMC Article
  3. SLAIN2 links microtubule plus end-tracking proteins and controls microtubule growth in interphase. van der Vaart B, et al. J Cell Biol, 2011 Jun 13. PMID 21646404, Free PMC Article
  4. An Alternative Splicing Program for Mouse Craniofacial Development. Hooper JE, et al. Front Physiol, 2020. PMID 33013468, Free PMC Article
  5. Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers. Wang C, et al. FASEB J, 2019 Aug. PMID 31162944, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circ-Slain2 Alleviates Cartilage Degradation and Inflammation of TMJOA.
    Title: Circ-Slain2 Alleviates Cartilage Degradation and Inflammation of TMJOA.
  2. Slain2 attenuates brain injury following subarachnoid hemorrhage by controlling axonal microtubule structure in mice.
    Title: Slain2 attenuates brain injury following subarachnoid hemorrhage by controlling axonal microtubule structure in mice.
  3. SLAIN2 is expressed throughout development and is highly enriched in brain.
    Title: Microtubule plus-end tracking proteins SLAIN1/2 and ch-TOG promote axonal development.
  4. Results identify SLAIN2 as a key component of microtubule plus end interaction networks.
    Title: SLAIN2 links microtubule plus end-tracking proteins and controls microtubule growth in interphase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1458, MGC47019

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic microtubule organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoplasmic microtubule organization ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule nucleation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of microtubule polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with microtubule plus-end ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SLAIN motif-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113423.2 → NP_001106894.1  SLAIN motif-containing protein 2 isoform b

    See identical proteins and their annotated locations for NP_001106894.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant1. It encodes isoform b, which lacks an internal segment and is shorter, compared to isoform a.
    Source sequence(s)
    AK029260, BB618957, BC076573, BY423831, BY736933
    Consensus CDS
    CCDS51517.1
    UniProtKB/Swiss-Prot
    Q05DK1, Q3UJI9, Q6ZPQ5, Q8CI08
    Related
    ENSMUSP00000116528.2, ENSMUST00000144843.8
    Conserved Domains (1) summary
    pfam15301
    Location:130 → 581
    SLAIN; SLAIN motif-containing family

  2. NM_153567.3 → NP_705795.2  SLAIN motif-containing protein 2 isoform a

    See identical proteins and their annotated locations for NP_705795.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK029260, AK039970, BB618957, BC076573, BY423831, BY736933, CF534366, CF728452, CK619668
    Consensus CDS
    CCDS19335.2
    UniProtKB/Swiss-Prot
    Q8CI08
    Related
    ENSMUSP00000115871.2, ENSMUST00000143829.5
    Conserved Domains (1) summary
    pfam15301
    Location:130 → 607
    SLAIN; SLAIN motif-containing family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    73071705..73136184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504171.3 → XP_006504234.1  SLAIN motif-containing protein 2 isoform X1

    Conserved Domains (1) summary
    pfam15301
    Location:1 → 466
    SLAIN; SLAIN motif-containing family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CI08.2 GenPept UniProtKB/Swiss-Prot:Q8CI08

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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