Dock11 dedicator of cytokinesis 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dock11provided by MGI
Official Full Name: dedicator of cytokinesis 11provided by MGI
Primary source: MGI:MGI:1923224
See related: Ensembl:ENSMUSG00000031093 AllianceGenome:MGI:1923224
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: sph238; Zizimin2; 8030476J24; 5033414A21Rik
Summary: Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in several processes, including marginal zone B cell differentiation; positive regulation of GTPase activity; and positive regulation of filopodium assembly. Is expressed in brain; female reproductive system; gut; skin; and spleen. Orthologous to human DOCK11 (dedicator of cytokinesis 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 4.2), CNS E14 (RPKM 3.9) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A3.3; X 20.35 cM

Exon count:: 57

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (35150924..35340223)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (35887271..36076570)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency.
Title: Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency.
Contribution of DOCK11 to the Expansion of Antigen-Specific Populations among Germinal Center B Cells.
Title: Contribution of DOCK11 to the Expansion of Antigen-Specific Populations among Germinal Center B Cells.
this study shows that Zizimin2 is involved in age-related defect of peritoneal B-1a cells as a source of anti-bacterial IgM
Title: Involvement of Zizimin2/3 in the age-related defect of peritoneal B-1a cells as a source of anti-bacterial IgM.
These data suggested that Zizimin2 is associated with the reduction of immune response in acquired immunity along with aging.
Title: Restricted expression of new guanine nucleotide exchange factor Zizimin2 in aged acquired immune system.
cloning of zizimin2; expressed predominantly in lymphocytes with an opposite pattern than zizimin1 [zizimin2]
Title: Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

px-2d6 (e-PCR)
- UniSTS:257546

19.MHAa91f7.seq (e-PCR)
- UniSTS:123413

px-46c4 (e-PCR)
- UniSTS:257842

px-48d2 (e-PCR)
- UniSTS:257860

px-46f10 (e-PCR)
- UniSTS:258417

px-72b1 (e-PCR)
- UniSTS:258169

RH102301 (e-PCR)
- UniSTS:96635

RH143347 (e-PCR)
- UniSTS:232594

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in marginal zone B cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in marginal zone B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of filopodium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: dedicator of cytokinesis protein 11

Names: ACG; activated Cdc42-associated guanine nucleotide exchange factor; spleen specific 238 kDa protein with PH domain; zizimin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009947.3 → NP_001009947.2 dedicator of cytokinesis protein 11

See identical proteins and their annotated locations for NP_001009947.2

Status: VALIDATED

Source sequence(s)

AL672023, AL672038

Consensus CDS

CCDS40923.1

UniProtKB/Swiss-Prot

A2AF47, Q5KTP7

UniProtKB/TrEMBL

A0A2X0U2I4

Related

ENSMUSP00000033419.6, ENSMUST00000033419.13

Conserved Domains (5) summary

cd08697
Location:639 → 828

C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11700
Location:1615 → 2027

DHR2_DOCK11; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 11

cd13267
Location:161 → 283

PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain

pfam00169
Location:166 → 271

PH; PH domain

pfam11878
Location:54 → 145

DUF3398; Domain of unknown function (DUF3398)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

35150924..35340223

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006541408.4 → XP_006541471.1 dedicator of cytokinesis protein 11 isoform X3

UniProtKB/TrEMBL

A0A2X0U2I4

Conserved Domains (4) summary

cd08697
Location:639 → 828

C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11700
Location:1628 → 2040

DHR2_DOCK11; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 11

cd13267
Location:161 → 283

PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain

pfam11878
Location:37 → 147

DUF3398; Domain of unknown function (DUF3398)
XM_006541406.4 → XP_006541469.1 dedicator of cytokinesis protein 11 isoform X1

UniProtKB/TrEMBL

A0A2X0U2I4

Conserved Domains (4) summary

cd08697
Location:639 → 828

C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11700
Location:1628 → 2040

DHR2_DOCK11; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 11

cd13267
Location:161 → 283

PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain

pfam11878
Location:37 → 147

DUF3398; Domain of unknown function (DUF3398)
XM_006541407.5 → XP_006541470.1 dedicator of cytokinesis protein 11 isoform X2

UniProtKB/TrEMBL

A0A2X0U2I4

Conserved Domains (4) summary

cd08697
Location:639 → 828

C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd11700
Location:1616 → 2028

DHR2_DOCK11; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 11

cd13267
Location:161 → 283

PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain

pfam11878
Location:37 → 147

DUF3398; Domain of unknown function (DUF3398)
XM_036162113.1 → XP_036018006.1 dedicator of cytokinesis protein 11 isoform X4

UniProtKB/TrEMBL

A0A2X0U2I4

Conserved Domains (4) summary

cd08697
Location:639 → 828

C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd13267
Location:161 → 283

PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain

pfam11878
Location:38 → 147

DUF3398; Domain of unknown function (DUF3398)

cl06123
Location:1562 → 1747

DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins
XM_036162114.1 → XP_036018007.1 dedicator of cytokinesis protein 11 isoform X5

Conserved Domains (3) summary

cd08697
Location:639 → 828

C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins

cd13267
Location:161 → 283

PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain

pfam11878
Location:38 → 147

DUF3398; Domain of unknown function (DUF3398)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_177745.2: Suppressed sequence

Description

NM_177745.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.