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Zdhhc20 zinc finger, DHHC domain containing 20 [ Mus musculus (house mouse) ]

Gene ID: 75965, updated on 8-May-2024

Summary

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Official Symbol
Zdhhc20provided by MGI
Official Full Name
zinc finger, DHHC domain containing 20provided by MGI
Primary source
MGI:MGI:1923215
See related
Ensembl:ENSMUSG00000021969 AllianceGenome:MGI:1923215
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HK11; 4930542A17Rik; 5033406L14Rik; B230110O18Rik
Summary
Predicted to enable protein-cysteine S-palmitoyltransferase activity and zinc ion binding activity. Predicted to be involved in peptidyl-L-cysteine S-palmitoylation and protein targeting to membrane. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Predicted to be integral component of Golgi membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Is expressed in early conceptus; inner cell mass; and oocyte. Orthologous to human ZDHHC20 (zinc finger DHHC-type palmitoyltransferase 20). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 9.8), limb E14.5 (RPKM 8.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 C3; 14 30.51 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (58070159..58128288, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (57832702..57890831, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10829 Neighboring gene spindle and kinetochore associated complex subunit 3 Neighboring gene mitochondrial ribosomal protein L57 Neighboring gene predicted gene, 22738 Neighboring gene STARR-seq mESC enhancer starr_36817 Neighboring gene STARR-seq mESC enhancer starr_36818 Neighboring gene STARR-positive B cell enhancer ABC_E7320 Neighboring gene STARR-seq mESC enhancer starr_36822 Neighboring gene STARR-positive B cell enhancer ABC_E8996 Neighboring gene STARR-positive B cell enhancer ABC_E8560 Neighboring gene mitochondrial calcium uptake 2 Neighboring gene RIKEN cDNA 3110083C13 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of PSD-95 palmitoylating enzymes. Fukata M, et al. Neuron, 2004 Dec 16. PMID 15603741
  2. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-cysteine S-palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-L-cysteine S-palmitoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation by host of viral process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein palmitoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
palmitoyltransferase ZDHHC20
Names
DHHC domain-containing cysteine-rich protein 20
DHHC-20
DHHC-containing protein 20
acyltransferase ZDHHC20
probable palmitoyltransferase ZDHHC20
zinc finger DHHC domain-containing protein 20
NP_001347026.1
NP_001347027.1
NP_083768.4
XP_006519721.1
XP_006519722.1
XP_006519723.1
XP_030103949.1
XP_030103950.1
XP_036014785.1
XP_036014786.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360097.1 → NP_001347026.1  palmitoyltransferase ZDHHC20 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC119813, AK017158, AK160951, AK163174, BC033914, BU609785
    Consensus CDS
    CCDS88676.1
    UniProtKB/Swiss-Prot
    Q3TDL1, Q5Y5T1, Q8VCL6, Q9D3Q8
    Related
    ENSMUSP00000153568.2, ENSMUST00000226057.2
    Conserved Domains (1) summary
    cl19890
    Location:16 → 316
    zf-DHHC; DHHC palmitoyltransferase

  2. NM_001360098.1 → NP_001347027.1  palmitoyltransferase ZDHHC20 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC119813, AK017158, AK160951, AK163174, BC033914
    Conserved Domains (1) summary
    cl19890
    Location:16 → 304
    zf-DHHC; DHHC palmitoyltransferase

  3. NM_029492.5 → NP_083768.4  palmitoyltransferase ZDHHC20 isoform 2

    See identical proteins and their annotated locations for NP_083768.4

    Status: VALIDATED

    Source sequence(s)
    AC119813, AK017158, AK160951, AK163174, BC033914
    Consensus CDS
    CCDS27162.1
    UniProtKB/Swiss-Prot
    Q5Y5T1
    Related
    ENSMUSP00000086900.4, ENSMUST00000089473.5
    Conserved Domains (1) summary
    cl19890
    Location:16 → 304
    zf-DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    58070159..58128288 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158893.1 → XP_036014786.1  palmitoyltransferase ZDHHC20 isoform X7

    Conserved Domains (1) summary
    cl19890
    Location:111 → 399
    DHHC; DHHC palmitoyltransferase

  2. XM_036158892.1 → XP_036014785.1  palmitoyltransferase ZDHHC20 isoform X6

    Conserved Domains (1) summary
    cl19890
    Location:111 → 411
    DHHC; DHHC palmitoyltransferase

  3. XM_006519659.4 → XP_006519722.1  palmitoyltransferase ZDHHC20 isoform X2

    Conserved Domains (1) summary
    cl19890
    Location:111 → 411
    DHHC; DHHC palmitoyltransferase

  4. XM_006519660.4 → XP_006519723.1  palmitoyltransferase ZDHHC20 isoform X3

    Conserved Domains (1) summary
    cl19890
    Location:111 → 411
    DHHC; DHHC palmitoyltransferase

  5. XM_006519658.5 → XP_006519721.1  palmitoyltransferase ZDHHC20 isoform X1

    See identical proteins and their annotated locations for XP_006519721.1

    Conserved Domains (1) summary
    cl19890
    Location:111 → 411
    DHHC; DHHC palmitoyltransferase

  6. XM_030248090.2 → XP_030103950.1  palmitoyltransferase ZDHHC20 isoform X5

    Conserved Domains (1) summary
    cl19890
    Location:111 → 399
    DHHC; DHHC palmitoyltransferase

  7. XM_030248089.1 → XP_030103949.1  palmitoyltransferase ZDHHC20 isoform X4

    Conserved Domains (1) summary
    COG5273
    Location:111 → 399
    COG5273; Uncharacterized protein containing DHHC-type Zn finger [General function prediction only]

RNA

  1. XR_001781166.2 RNA Sequence

  2. XR_003950907.1 RNA Sequence

  3. XR_004938459.1 RNA Sequence

  4. XR_001781165.2 RNA Sequence

  5. XR_003950906.1 RNA Sequence

  6. XR_003950908.1 RNA Sequence

  7. XR_004938458.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5Y5T1.1 GenPept UniProtKB/Swiss-Prot:Q5Y5T1

Gene LinkOut

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