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Samd7 sterile alpha motif domain containing 7 [ Mus musculus (house mouse) ]

Gene ID: 75953, updated on 5-Mar-2024

Summary

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Official Symbol
Samd7provided by MGI
Official Full Name
sterile alpha motif domain containing 7provided by MGI
Primary source
MGI:MGI:1923203
See related
Ensembl:ENSMUSG00000051860 AllianceGenome:MGI:1923203
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930597A01Rik
Summary
Predicted to enable chromatin binding activity and histone binding activity. Involved in negative regulation of gene expression. Located in cytoplasm and nucleus. Is expressed in central nervous system; dorsal root ganglion; liver; metanephros; and neural retina. Orthologous to human SAMD7 (sterile alpha motif domain containing 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 1.3) and CNS E18 (RPKM 0.1) See more
Orthologs
human all
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Genomic context

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Location:
3 A3; 3 14.27 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (30800481..30821323)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (30746293..30767174)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 34 Neighboring gene STARR-seq mESC enhancer starr_07297 Neighboring gene STARR-seq mESC enhancer starr_07298 Neighboring gene leucine-rich repeats and IQ motif containing 4 Neighboring gene STARR-seq mESC enhancer starr_07299 Neighboring gene leucine rich repeat containing 31 Neighboring gene predicted gene 15462 Neighboring gene STARR-seq mESC enhancer starr_07301 Neighboring gene predicted gene, 33590 Neighboring gene SEC62 homolog, preprotein translocation Neighboring gene predicted gene, 42198

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Samd7 is a cell type-specific PRC1 component essential for establishing retinal rod photoreceptor identity. Omori Y, et al. Proc Natl Acad Sci U S A, 2017 Sep 26. PMID 28900001, Free PMC Article
  2. Functional analysis of Samd11, a retinal photoreceptor PRC1 component, in establishing rod photoreceptor identity. Kubo S, et al. Sci Rep, 2021 Feb 18. PMID 33603070, Free PMC Article
  3. Sterile alpha motif containing 7 (samd7) is a novel crx-regulated transcriptional repressor in the retina. Hlawatsch J, et al. PLoS One, 2013. PMID 23565263, Free PMC Article
  4. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  5. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The current study suggests that Samd7 is a cell type-specific PRC1 component epigenetically defining rod photoreceptor cell identity.
    Title: Samd7 is a cell type-specific PRC1 component essential for establishing retinal rod photoreceptor identity.
  2. Data have identified a novel retinal SAM domain protein, Samd7, which could act as a transcriptional repressor involved in fine-tuning of Crx-regulated gene expression.
    Title: Sterile alpha motif containing 7 (samd7) is a novel crx-regulated transcriptional repressor in the retina.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of gene expression, epigenetic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retinal rod cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of PRC1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sterile alpha motif domain-containing protein 7
Names
SAM domain-containing protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029489.4 → NP_083765.2  sterile alpha motif domain-containing protein 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and is a protein-coding transcript.
    Source sequence(s)
    AC158135
    Consensus CDS
    CCDS17285.2
    UniProtKB/Swiss-Prot
    F8WHA0, G3UXH0, Q8C8Y5
    Related
    ENSMUSP00000103897.4, ENSMUST00000108262.10
    Conserved Domains (1) summary
    cd09579
    Location:321 → 388
    SAM_Samd7,11; SAM domain of Samd7,11 subfamily of Polycomb group

RNA

  1. NR_028060.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD) and is therefore not thought to be protein-coding.
    Source sequence(s)
    AC158135
    Related
    ENSMUST00000174395.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    30800481..30821323
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319791.1 → XP_017175280.1  sterile alpha motif domain-containing protein 7 isoform X1

    UniProtKB/Swiss-Prot
    F8WHA0, G3UXH0, Q8C8Y5
    Conserved Domains (1) summary
    cd09579
    Location:321 → 388
    SAM_Samd7,11; SAM domain of Samd7,11 subfamily of Polycomb group
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C8Y5.4 GenPept UniProtKB/Swiss-Prot:Q8C8Y5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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