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Zfp821 zinc finger protein 821 [ Mus musculus (house mouse) ]

Gene ID: 75871, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp821provided by MGI
Official Full Name
zinc finger protein 821provided by MGI
Primary source
MGI:MGI:1923121
See related
Ensembl:ENSMUSG00000031728 AllianceGenome:MGI:1923121
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf821; 4930566A11Rik
Summary
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; and retina nuclear layer. Orthologous to human ZNF821 (zinc finger protein 821). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E14 (RPKM 11.3), testis adult (RPKM 11.1) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 D3; 8 57.21 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (110421884..110451564)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (109695252..109724932)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:112132543-112132726 Neighboring gene dihydroorotate dehydrogenase Neighboring gene polycystic kidney disease 1 like 3 Neighboring gene increased sodium tolerance 1 homolog (yeast) Neighboring gene STARR-positive B cell enhancer ABC_E3805 Neighboring gene predicted gene, 53453 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:112261750-112261859 Neighboring gene ataxin 1-like Neighboring gene STARR-seq mESC enhancer starr_22658 Neighboring gene predicted gene, 51550 Neighboring gene La ribonucleoprotein domain family, member 1B pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Zfp819, a novel KRAB-zinc finger protein, interacts with KAP1 and functions in genomic integrity maintenance of mouse embryonic stem cells. Tan X, et al. Stem Cell Res, 2013 Nov. PMID 23954693
  2. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
  3. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 821

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167946.2 → NP_001161418.1  zinc finger protein 821 isoform a

    See identical proteins and their annotated locations for NP_001161418.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 5-8 all encode the same isoform (a).
    Source sequence(s)
    AC132138, AK136168, BC059844
    Consensus CDS
    CCDS40473.1
    UniProtKB/Swiss-Prot
    E9Q0F1, Q3UWR1, Q6PD05
    UniProtKB/TrEMBL
    A0A1D5RLA9
    Related
    ENSMUSP00000034163.9, ENSMUST00000034163.9
    Conserved Domains (4) summary
    sd00017
    Location:121 → 141
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:151 → 173
    zf-C2H2; Zinc finger, C2H2 type
    pfam07946
    Location:290 → 355
    DUF1682; Protein of unknown function (DUF1682)
    cl27170
    Location:243 → 383
    DUF460; Protein of unknown function (DUF460)

  2. NM_001286391.1 → NP_001273320.1  zinc finger protein 821 isoform b

    See identical proteins and their annotated locations for NP_001273320.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 3, 4, and 9-11 all encode the same isoform (b).
    Source sequence(s)
    AC132138, AK165387, BC059844
    Consensus CDS
    CCDS85609.1
    UniProtKB/TrEMBL
    A0A1D5RLE5, Q8R572
    Conserved Domains (2) summary
    TIGR01642
    Location:125 → 237
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    sd00017
    Location:2 → 22
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001286393.1 → NP_001273322.1  zinc finger protein 821 isoform b

    See identical proteins and their annotated locations for NP_001273322.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to variant 1. The resulting isoform (b) has a shorter N-terminus compared to isoform a. Variants 3, 4 and 9-11 all encode the same isoform (b).
    Source sequence(s)
    AC132138, AK136168, BC059844
    Consensus CDS
    CCDS85609.1
    UniProtKB/TrEMBL
    A0A1D5RLE5, Q8R572
    Related
    ENSMUSP00000148334.2, ENSMUST00000212964.2
    Conserved Domains (2) summary
    TIGR01642
    Location:125 → 237
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    sd00017
    Location:2 → 22
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_001363380.1 → NP_001350309.1  zinc finger protein 821 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 1, 2, and 6-8, encodes isoform a.
    Source sequence(s)
    AC132138, BC059014, CN714981, CN721180
    Consensus CDS
    CCDS40473.1
    UniProtKB/Swiss-Prot
    E9Q0F1, Q3UWR1, Q6PD05
    UniProtKB/TrEMBL
    A0A1D5RLA9
    Conserved Domains (4) summary
    sd00017
    Location:121 → 141
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:151 → 173
    zf-C2H2; Zinc finger, C2H2 type
    pfam07946
    Location:290 → 355
    DUF1682; Protein of unknown function (DUF1682)
    cl27170
    Location:243 → 383
    DUF460; Protein of unknown function (DUF460)

  5. NM_001363381.1 → NP_001350310.1  zinc finger protein 821 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 1, 2, 5, 7, and 8, encodes isoform a.
    Source sequence(s)
    AC132138, BC059014
    Consensus CDS
    CCDS40473.1
    UniProtKB/Swiss-Prot
    E9Q0F1, Q3UWR1, Q6PD05
    UniProtKB/TrEMBL
    A0A1D5RLA9
    Conserved Domains (4) summary
    sd00017
    Location:121 → 141
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:151 → 173
    zf-C2H2; Zinc finger, C2H2 type
    pfam07946
    Location:290 → 355
    DUF1682; Protein of unknown function (DUF1682)
    cl27170
    Location:243 → 383
    DUF460; Protein of unknown function (DUF460)

  6. NM_001363382.1 → NP_001350311.1  zinc finger protein 821 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variants 1, 2, 5, 6, and 8, encodes isoform a.
    Source sequence(s)
    AC132138, BC059014, CF173118
    Consensus CDS
    CCDS40473.1
    UniProtKB/Swiss-Prot
    E9Q0F1, Q3UWR1, Q6PD05
    UniProtKB/TrEMBL
    A0A1D5RLA9
    Conserved Domains (4) summary
    sd00017
    Location:121 → 141
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:151 → 173
    zf-C2H2; Zinc finger, C2H2 type
    pfam07946
    Location:290 → 355
    DUF1682; Protein of unknown function (DUF1682)
    cl27170
    Location:243 → 383
    DUF460; Protein of unknown function (DUF460)

  7. NM_001363383.1 → NP_001350312.1  zinc finger protein 821 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 1, 2, 5, 6, and 7, encodes isoform a
    Source sequence(s)
    AC132138
    Consensus CDS
    CCDS40473.1
    UniProtKB/Swiss-Prot
    E9Q0F1, Q3UWR1, Q6PD05
    UniProtKB/TrEMBL
    A0A1D5RLA9
    Conserved Domains (4) summary
    sd00017
    Location:121 → 141
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:151 → 173
    zf-C2H2; Zinc finger, C2H2 type
    pfam07946
    Location:290 → 355
    DUF1682; Protein of unknown function (DUF1682)
    cl27170
    Location:243 → 383
    DUF460; Protein of unknown function (DUF460)

  8. NM_001363384.1 → NP_001350313.1  zinc finger protein 821 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variants 3, 4, 10, and 11, encodes isoform b.
    Source sequence(s)
    AC132138, BC059014, CN721180
    Consensus CDS
    CCDS85609.1
    UniProtKB/TrEMBL
    A0A1D5RLE5, Q8R572
    Conserved Domains (2) summary
    TIGR01642
    Location:125 → 237
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    sd00017
    Location:2 → 22
    ZF_C2H2; C2H2 Zn finger [structural motif]

  9. NM_001363385.1 → NP_001350314.1  zinc finger protein 821 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC132138
    Consensus CDS
    CCDS85609.1
    UniProtKB/TrEMBL
    A0A1D5RLE5, Q8R572
    Conserved Domains (2) summary
    TIGR01642
    Location:125 → 237
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    sd00017
    Location:2 → 22
    ZF_C2H2; C2H2 Zn finger [structural motif]

  10. NM_001363386.1 → NP_001350315.1  zinc finger protein 821 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variants 3, 4, 9, and 10, encodes isoform b.
    Source sequence(s)
    AC132138, BC059014, BM950913
    Consensus CDS
    CCDS85609.1
    UniProtKB/TrEMBL
    A0A1D5RLE5, Q8R572
    Conserved Domains (2) summary
    TIGR01642
    Location:125 → 237
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    sd00017
    Location:2 → 22
    ZF_C2H2; C2H2 Zn finger [structural motif]

  11. NM_029468.3 → NP_083744.2  zinc finger protein 821 isoform a

    See identical proteins and their annotated locations for NP_083744.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, and 5-8 all encode the same isoform (a).
    Source sequence(s)
    BC059014, BC059844, BY240329
    Consensus CDS
    CCDS40473.1
    UniProtKB/Swiss-Prot
    E9Q0F1, Q3UWR1, Q6PD05
    UniProtKB/TrEMBL
    A0A1D5RLA9
    Related
    ENSMUSP00000148348.2, ENSMUST00000212000.2
    Conserved Domains (4) summary
    sd00017
    Location:121 → 141
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:151 → 173
    zf-C2H2; Zinc finger, C2H2 type
    pfam07946
    Location:290 → 355
    DUF1682; Protein of unknown function (DUF1682)
    cl27170
    Location:243 → 383
    DUF460; Protein of unknown function (DUF460)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    110421884..110451564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243833.1 → XP_030099693.1  zinc finger protein 821 isoform X2

    UniProtKB/TrEMBL
    A0A1D5RLE5, Q8R572
    Conserved Domains (2) summary
    TIGR01642
    Location:125 → 237
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    sd00017
    Location:2 → 22
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_036154363.1 → XP_036010256.1  zinc finger protein 821 isoform X2

    UniProtKB/TrEMBL
    A0A1D5RLE5, Q8R572
    Conserved Domains (2) summary
    TIGR01642
    Location:125 → 237
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    sd00017
    Location:2 → 22
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_036154360.1 → XP_036010253.1  zinc finger protein 821 isoform X2

    UniProtKB/TrEMBL
    A0A1D5RLE5, Q8R572
    Conserved Domains (2) summary
    TIGR01642
    Location:125 → 237
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    sd00017
    Location:2 → 22
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_011248534.4 → XP_011246836.1  zinc finger protein 821 isoform X1

    See identical proteins and their annotated locations for XP_011246836.1

    UniProtKB/Swiss-Prot
    E9Q0F1, Q3UWR1, Q6PD05
    UniProtKB/TrEMBL
    A0A1D5RLA9
    Conserved Domains (4) summary
    sd00017
    Location:121 → 141
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:151 → 173
    zf-C2H2; Zinc finger, C2H2 type
    pfam07946
    Location:290 → 355
    DUF1682; Protein of unknown function (DUF1682)
    cl27170
    Location:243 → 383
    DUF460; Protein of unknown function (DUF460)

  5. XM_036154358.1 → XP_036010251.1  zinc finger protein 821 isoform X2

    UniProtKB/TrEMBL
    A0A1D5RLE5, Q8R572
    Conserved Domains (2) summary
    TIGR01642
    Location:125 → 237
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    sd00017
    Location:2 → 22
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. XM_036154362.1 → XP_036010255.1  zinc finger protein 821 isoform X2

    UniProtKB/TrEMBL
    A0A1D5RLE5, Q8R572
    Conserved Domains (2) summary
    TIGR01642
    Location:125 → 237
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    sd00017
    Location:2 → 22
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. XM_036154359.1 → XP_036010252.1  zinc finger protein 821 isoform X2

    UniProtKB/TrEMBL
    A0A1D5RLE5, Q8R572
    Conserved Domains (2) summary
    TIGR01642
    Location:125 → 237
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    sd00017
    Location:2 → 22
    ZF_C2H2; C2H2 Zn finger [structural motif]

  8. XM_030243831.1 → XP_030099691.1  zinc finger protein 821 isoform X1

    UniProtKB/Swiss-Prot
    E9Q0F1, Q3UWR1, Q6PD05
    UniProtKB/TrEMBL
    A0A1D5RLA9
    Conserved Domains (4) summary
    sd00017
    Location:121 → 141
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:151 → 173
    zf-C2H2; Zinc finger, C2H2 type
    pfam07946
    Location:290 → 355
    DUF1682; Protein of unknown function (DUF1682)
    cl27170
    Location:243 → 383
    DUF460; Protein of unknown function (DUF460)

  9. XM_036154357.1 → XP_036010250.1  zinc finger protein 821 isoform X2

    UniProtKB/TrEMBL
    A0A1D5RLE5, Q8R572
    Conserved Domains (2) summary
    TIGR01642
    Location:125 → 237
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    sd00017
    Location:2 → 22
    ZF_C2H2; C2H2 Zn finger [structural motif]

  10. XM_030243832.2 → XP_030099692.1  zinc finger protein 821 isoform X2

    UniProtKB/TrEMBL
    A0A1D5RLE5, Q8R572
    Conserved Domains (2) summary
    TIGR01642
    Location:125 → 237
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
    sd00017
    Location:2 → 22
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PD05.2 GenPept UniProtKB/Swiss-Prot:Q6PD05

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