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ZNF37A zinc finger protein 37A [ Homo sapiens (human) ]

Gene ID: 7587, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF37Aprovided by HGNC
Official Full Name
zinc finger protein 37Aprovided by HGNC
Primary source
HGNC:HGNC:13102
See related
Ensembl:ENSG00000075407 MIM:616085; AllianceGenome:HGNC:13102
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KOX21; ZNF37
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 3.1), endometrium (RPKM 2.4) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
10p11.1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (38094337..38150293)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (38138318..38194251)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (38383265..38439221)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 3 subunit L pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3274 Neighboring gene FXYD domain containing ion transport regulator 6 pseudogene 2 Neighboring gene uncharacterized LOC105376500 Neighboring gene cyclin Y like 4 (pseudogene)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A defective Krab-domain zinc-finger transcription factor contributes to altered myogenesis in myotonic dystrophy type 1. Gauthier M, et al. Hum Mol Genet, 2013 Dec 20. PMID 23922231
  2. ZNF37A promotes tumor metastasis through transcriptional control of THSD4/TGF-β axis in colorectal cancer. Liu J, et al. Oncogene, 2021 May. PMID 33875786
  3. Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10p. Guy J, et al. Genome Res, 2003 Feb. PMID 12566394, Free PMC Article
  4. Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution. Tunnacliffe A, et al. Nucleic Acids Res, 1993 Mar 25. PMID 8464732, Free PMC Article
  5. Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. Huebner K, et al. Am J Hum Genet, 1991 Apr. PMID 2014798, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF37A promotes tumor metastasis through transcriptional control of THSD4/TGF-beta axis in colorectal cancer.
    Title: ZNF37A promotes tumor metastasis through transcriptional control of THSD4/TGF-β axis in colorectal cancer.
  2. This suggests that the pathological molecular mechanisms linking ZNF37A and myogenesis may involve the signaling pathway that is known to promote myoblast recruitment during development and regeneration
    Title: A defective Krab-domain zinc-finger transcription factor contributes to altered myogenesis in myotonic dystrophy type 1.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ3472

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 37A
Names
zinc finger protein 37a (KOX 21)
zinc finger protein KOX21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007094.4 → NP_001007095.1  zinc finger protein 37A isoform a

    See identical proteins and their annotated locations for NP_001007095.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AL117339
    Consensus CDS
    CCDS31183.1
    UniProtKB/Swiss-Prot
    B3KRQ3, D3DRZ3, P17032, Q96B88
    Related
    ENSP00000329141.3, ENST00000351773.7
    Conserved Domains (4) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:269 → 421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301 → 321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:426 → 448
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001178101.3 → NP_001171572.1  zinc finger protein 37A isoform a

    See identical proteins and their annotated locations for NP_001171572.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal segment and uses a different splice site in the 5' UTR, compared to variant 1. Variants 1-10 all encode the same protein.
    Source sequence(s)
    AL117339
    Consensus CDS
    CCDS31183.1
    UniProtKB/Swiss-Prot
    B3KRQ3, D3DRZ3, P17032, Q96B88
    Conserved Domains (4) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:269 → 421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301 → 321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:426 → 448
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001324245.3 → NP_001311174.1  zinc finger protein 37A isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 1-3 and 5-10, encodes isoform a.
    Source sequence(s)
    AL117339
    Consensus CDS
    CCDS31183.1
    UniProtKB/Swiss-Prot
    B3KRQ3, D3DRZ3, P17032, Q96B88
    Conserved Domains (4) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:269 → 421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301 → 321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:426 → 448
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001324246.3 → NP_001311175.1  zinc finger protein 37A isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 1-4 and 6-10, encodes isoform a.
    Source sequence(s)
    AL117339
    Consensus CDS
    CCDS31183.1
    UniProtKB/Swiss-Prot
    B3KRQ3, D3DRZ3, P17032, Q96B88
    Conserved Domains (4) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:269 → 421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301 → 321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:426 → 448
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001324247.3 → NP_001311176.1  zinc finger protein 37A isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 1-5 and 7-10, encodes isoform a.
    Source sequence(s)
    AL117339
    Consensus CDS
    CCDS31183.1
    UniProtKB/Swiss-Prot
    B3KRQ3, D3DRZ3, P17032, Q96B88
    Conserved Domains (4) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:269 → 421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301 → 321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:426 → 448
    zf-H2C2_2; Zinc-finger double domain

  6. NM_001324248.3 → NP_001311177.1  zinc finger protein 37A isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variants 1-6 and 8-10, encodes isoform a.
    Source sequence(s)
    AL117339
    Consensus CDS
    CCDS31183.1
    UniProtKB/Swiss-Prot
    B3KRQ3, D3DRZ3, P17032, Q96B88
    Conserved Domains (4) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:269 → 421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301 → 321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:426 → 448
    zf-H2C2_2; Zinc-finger double domain

  7. NM_001324249.3 → NP_001311178.1  zinc finger protein 37A isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 1-7 and 9-10, encodes isoform a.
    Source sequence(s)
    AL117339
    Consensus CDS
    CCDS31183.1
    UniProtKB/Swiss-Prot
    B3KRQ3, D3DRZ3, P17032, Q96B88
    Conserved Domains (4) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:269 → 421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301 → 321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:426 → 448
    zf-H2C2_2; Zinc-finger double domain

  8. NM_001324250.3 → NP_001311179.1  zinc finger protein 37A isoform a

    Status: VALIDATED

    Source sequence(s)
    AL117339
    Consensus CDS
    CCDS31183.1
    UniProtKB/Swiss-Prot
    B3KRQ3, D3DRZ3, P17032, Q96B88
    Related
    ENSP00000508865.1, ENST00000685332.1
    Conserved Domains (4) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:269 → 421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301 → 321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:426 → 448
    zf-H2C2_2; Zinc-finger double domain

  9. NM_001324251.3 → NP_001311180.1  zinc finger protein 37A isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 1-9, encodes isoform a.
    Source sequence(s)
    AL117339
    Consensus CDS
    CCDS31183.1
    UniProtKB/Swiss-Prot
    B3KRQ3, D3DRZ3, P17032, Q96B88
    Conserved Domains (4) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:269 → 421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301 → 321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:426 → 448
    zf-H2C2_2; Zinc-finger double domain

  10. NM_001324252.2 → NP_001311181.1  zinc finger protein 37A isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variants 12 and 13, encodes isoform b.
    Source sequence(s)
    AL117339
    Conserved Domains (1) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box

  11. NM_001324253.2 → NP_001311182.1  zinc finger protein 37A isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variants 11 and 13, encodes isoform b.
    Source sequence(s)
    AL117339
    Conserved Domains (1) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box

  12. NM_001324254.2 → NP_001311183.1  zinc finger protein 37A isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variants 11 and 12, encodes isoform b.
    Source sequence(s)
    AL117339
    Conserved Domains (1) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box

  13. NM_001324256.2 → NP_001311185.1  zinc finger protein 37A isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14), as well as variants 15-16, encodes isoform c.
    Source sequence(s)
    AL117339
    Consensus CDS
    CCDS81451.1
    UniProtKB/TrEMBL
    A0A1B0GVV4
    Related
    ENSP00000490669.1, ENST00000638053.1

  14. NM_001324257.2 → NP_001311186.1  zinc finger protein 37A isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15), as well as variants 14 and 16, encodes isoform c.
    Source sequence(s)
    AL117339
    Consensus CDS
    CCDS81451.1
    UniProtKB/TrEMBL
    A0A1B0GVV4

  15. NM_001324258.2 → NP_001311187.1  zinc finger protein 37A isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16), as well as variants 14-15, encodes isoform c.
    Source sequence(s)
    AL117339
    Consensus CDS
    CCDS81451.1
    UniProtKB/TrEMBL
    A0A1B0GVV4

  16. NM_001324259.3 → NP_001311188.1  zinc finger protein 37A isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17) and variant 18 both encode isoform d.
    Source sequence(s)
    AL117339
    Conserved Domains (1) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box

  17. NM_001324260.3 → NP_001311189.1  zinc finger protein 37A isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18) and variant 17 both encode isoform d.
    Source sequence(s)
    AL117339
    Conserved Domains (1) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box

  18. NM_001324261.2 → NP_001311190.1  zinc finger protein 37A isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19) and variant 20 both encode isoform e.
    Source sequence(s)
    AL117339
    Conserved Domains (1) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box

  19. NM_001324262.2 → NP_001311191.1  zinc finger protein 37A isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20) and variant 19 both encode isoform e.
    Source sequence(s)
    AL117339
    Conserved Domains (1) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box

  20. NM_003421.4 → NP_003412.1  zinc finger protein 37A isoform a

    See identical proteins and their annotated locations for NP_003412.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal segment in the 5' UTR, compared to variant 1. Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AL117339
    Consensus CDS
    CCDS31183.1
    UniProtKB/Swiss-Prot
    B3KRQ3, D3DRZ3, P17032, Q96B88
    Related
    ENSP00000354377.4, ENST00000361085.9
    Conserved Domains (4) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:269 → 421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301 → 321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:426 → 448
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    38094337..38150293
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425722.1 → XP_047281678.1  zinc finger protein 37A isoform X1

    UniProtKB/Swiss-Prot
    B3KRQ3, D3DRZ3, P17032, Q96B88

  2. XM_011519656.3 → XP_011517958.1  zinc finger protein 37A isoform X1

    See identical proteins and their annotated locations for XP_011517958.1

    UniProtKB/Swiss-Prot
    B3KRQ3, D3DRZ3, P17032, Q96B88
    Conserved Domains (4) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:269 → 421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301 → 321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:426 → 448
    zf-H2C2_2; Zinc-finger double domain

  3. XM_011519657.3 → XP_011517959.1  zinc finger protein 37A isoform X1

    See identical proteins and their annotated locations for XP_011517959.1

    UniProtKB/Swiss-Prot
    B3KRQ3, D3DRZ3, P17032, Q96B88
    Conserved Domains (4) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:269 → 421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301 → 321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:426 → 448
    zf-H2C2_2; Zinc-finger double domain

  4. XM_011519658.4 → XP_011517960.1  zinc finger protein 37A isoform X1

    See identical proteins and their annotated locations for XP_011517960.1

    UniProtKB/Swiss-Prot
    B3KRQ3, D3DRZ3, P17032, Q96B88
    Conserved Domains (4) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:269 → 421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301 → 321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:426 → 448
    zf-H2C2_2; Zinc-finger double domain

  5. XM_017016624.1 → XP_016872113.1  zinc finger protein 37A isoform X5

    Related
    ENST00000479469.5
    Conserved Domains (1) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box

  6. XM_047425724.1 → XP_047281680.1  zinc finger protein 37A isoform X4

  7. XM_047425723.1 → XP_047281679.1  zinc finger protein 37A isoform X3

  8. XM_005252586.5 → XP_005252643.1  zinc finger protein 37A isoform X2

    See identical proteins and their annotated locations for XP_005252643.1

    Conserved Domains (3) summary
    COG5048
    Location:55 → 471
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:211 → 231
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:307 → 331
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    38138318..38194251
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366696.1 → XP_054222671.1  zinc finger protein 37A isoform X1

    UniProtKB/Swiss-Prot
    B3KRQ3, D3DRZ3, P17032, Q96B88

  2. XM_054366695.1 → XP_054222670.1  zinc finger protein 37A isoform X1

    UniProtKB/Swiss-Prot
    B3KRQ3, D3DRZ3, P17032, Q96B88

  3. XM_054366698.1 → XP_054222673.1  zinc finger protein 37A isoform X1

    UniProtKB/Swiss-Prot
    B3KRQ3, D3DRZ3, P17032, Q96B88

  4. XM_054366697.1 → XP_054222672.1  zinc finger protein 37A isoform X1

    UniProtKB/Swiss-Prot
    B3KRQ3, D3DRZ3, P17032, Q96B88

  5. XM_054366702.1 → XP_054222677.1  zinc finger protein 37A isoform X5

  6. XM_054366701.1 → XP_054222676.1  zinc finger protein 37A isoform X4

  7. XM_054366700.1 → XP_054222675.1  zinc finger protein 37A isoform X3

  8. XM_054366699.1 → XP_054222674.1  zinc finger protein 37A isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17032.3 GenPept UniProtKB/Swiss-Prot:P17032

Gene LinkOut

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