Clec4g C-type lectin domain family 4, member g [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Clec4gprovided by MGI
Official Full Name: C-type lectin domain family 4, member gprovided by MGI
Primary source: MGI:MGI:1923113
See related: Ensembl:ENSMUSG00000074491 AllianceGenome:MGI:1923113
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4930572L20Rik
Summary: Enables polysaccharide binding activity. Acts upstream of or within negative regulation of T cell mediated immunity and negative regulation of T cell proliferation. Located in plasma membrane. Orthologous to human CLEC4G (C-type lectin domain family 4 member G). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 8.6), testis adult (RPKM 6.3) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A1.1; 8 1.92 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (3757066..3770695, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (3707066..3720695, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study shows that C-type lectin LSECtin, a member of the DC-SIGN family, is a novel liver regulator for natural killer cells (NK cells). LSECtin could bind to NK cells in a carbohydrate-dependent manner and could regulate the number of hepatic NK cells.
Title: Involvement of LSECtin in the hepatic natural killer cell response.
Data show that C-type lectin-like domain family 4, member g (Clec4g) suppresses beta-Site amyloid precursor protein cleaving enzyme-1 (BACE1)-mediated amyloid-beta (Abeta) peptides generation.
Title: Clec4g (LSECtin) interacts with BACE1 and suppresses Aβ generation.
When expressed in B16 melanoma cells, LSECtin promoted tumor growth, whereas its blockade slowed tumor growth in either wild-type or LSECtin-deficient mice.
Title: LSECtin expressed on melanoma cells promotes tumor progression by inhibiting antitumor T-cell responses.
LSECtin-mediated signaling up-regulates the threshold of CD4(+) T cell activation via tuning the expression of Cbl-b.
Title: Up-regulation of Cbl-b is associated with LSECtin-mediated inhibition of different CD4+ T-cell subsets.
LSECtin may facilitate the reduction of liver inflammation at the cost of delaying virus clearance, an effect that might be hijacked by the virus as an escape mechanism.
Title: Liver sinusoidal endothelial cell lectin inhibits CTL-dependent virus clearance in mouse models of viral hepatitis.
The studies provide a basis for using mouse LSECtin, and knockout mice lacking this receptor, to model the biological properties of the human receptor.
Title: Mouse LSECtin as a model for a human Ebola virus receptor.
Liver sinusoidal endothelial cell lectin, LSECtin, negatively regulates hepatic T-cell immune response.
Title: Liver sinusoidal endothelial cell lectin, LSECtin, negatively regulates hepatic T-cell immune response.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IBA Inferred from Biological aspect of Ancestor more info
enables carbohydrate derivative binding	ISO Inferred from Sequence Orthology more info
enables fructose binding	ISO Inferred from Sequence Orthology more info
enables mannose binding	ISO Inferred from Sequence Orthology more info
enables polysaccharide binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables virus coreceptor activity	ISO Inferred from Sequence Orthology more info
enables virus receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of T cell mediated immunity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of alpha-beta T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in biological process involved in interspecies interaction between organisms	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of immature T cell proliferation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of T cell mediated immunity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of T cell mediated immunity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of alpha-beta T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of immature T cell proliferation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of viral life cycle	ISO Inferred from Sequence Orthology more info
involved_in symbiont entry into host cell	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: C-type lectin domain family 4 member G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029465.3 → NP_083741.1 C-type lectin domain family 4 member G

See identical proteins and their annotated locations for NP_083741.1

Status: VALIDATED

Source sequence(s)

AI449163, AK079992

Consensus CDS

CCDS22072.1

UniProtKB/Swiss-Prot

Q5I0T7, Q8BNX1, Q8R188

Related

ENSMUSP00000059574.7, ENSMUST00000062037.7

Conserved Domains (2) summary

cl02432
Location:165 → 289

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

cl19764
Location:61 → 163

COG6; Conserved oligomeric complex COG6