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Rnf139 ring finger protein 139 [ Mus musculus (house mouse) ]

Gene ID: 75841, updated on 5-Mar-2024

Summary

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Official Symbol
Rnf139provided by MGI
Official Full Name
ring finger protein 139provided by MGI
Primary source
MGI:MGI:1923091
See related
Ensembl:ENSMUSG00000037075 AllianceGenome:MGI:1923091
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930555P18Rik
Summary
Predicted to enable protease binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular protein metabolic process; protein destabilization; and regulation of protein metabolic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of Derlin-1 retrotranslocation complex. Predicted to be active in endoplasmic reticulum. Is expressed in bladder; testis; and ureter. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human RNF139 (ring finger protein 139). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 73.5), liver E14 (RPKM 11.8) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Rnf139 in Genome Data Viewer
Location:
15 D1; 15 25.09 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (58760975..58774239)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (58889229..58902390)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3142 Neighboring gene tRNA methyltransferase 12 Neighboring gene predicted gene, 36509 Neighboring gene TatD DNase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_38762 Neighboring gene STARR-positive B cell enhancer ABC_E8590 Neighboring gene NADH:ubiquinone oxidoreductase subunit B9 Neighboring gene MTSS I-BAR domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E8591 Neighboring gene RIKEN cDNA 4930544F09 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TRC8 downregulation contributes to the development of non-alcoholic steatohepatitis by exacerbating hepatic endoplasmic reticulum stress. Chang PC, et al. Biochim Biophys Acta, 2015 Nov. PMID 26319415
  2. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
  3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protease binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-like protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein destabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ER to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Derlin-1 retrotranslocation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Derlin-1 retrotranslocation complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF139
Names
RING-type E3 ubiquitin transferase RNF139
translocation in renal carcinoma on chromosome 8 protein
NP_780435.1
XP_017172276.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175226.4 → NP_780435.1  E3 ubiquitin-protein ligase RNF139

    See identical proteins and their annotated locations for NP_780435.1

    Status: VALIDATED

    Source sequence(s)
    AK029069, AK033506, CJ180442
    Consensus CDS
    CCDS27494.1
    UniProtKB/Swiss-Prot
    Q7TMV1, Q8BZU9
    UniProtKB/TrEMBL
    A0A0R4J0K8
    Related
    ENSMUSP00000046467.7, ENSMUST00000036904.7
    Conserved Domains (2) summary
    cd16683
    Location:545 → 586
    RING-H2_RNF139; RING finger, H2 subclass, found in RING finger protein 139 (RNF139) and similar proteins
    pfam13705
    Location:19 → 516
    TRC8_N; TRC8 N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    58760975..58774239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316787.3 → XP_017172276.1  E3 ubiquitin-protein ligase RNF139 isoform X1

    UniProtKB/Swiss-Prot
    Q7TMV1, Q8BZU9
    Conserved Domains (2) summary
    cd16683
    Location:465 → 506
    RING-H2_RNF139; RING finger, H2 subclass, found in RING finger protein 139 (RNF139) and similar proteins
    pfam13705
    Location:5 → 436
    TRC8_N; TRC8 N-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TMV1.1 GenPept UniProtKB/Swiss-Prot:Q7TMV1

Gene LinkOut

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