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Tasp1 taspase, threonine aspartase 1 [ Mus musculus (house mouse) ]

Gene ID: 75812, updated on 5-Mar-2024

Summary

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Official Symbol
Tasp1provided by MGI
Official Full Name
taspase, threonine aspartase 1provided by MGI
Primary source
MGI:MGI:1923062
See related
Ensembl:ENSMUSG00000039033 AllianceGenome:MGI:1923062
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930485D02Rik
Summary
Predicted to enable identical protein binding activity and threonine-type endopeptidase activity. Predicted to be involved in positive regulation of transcription, DNA-templated; protein maturation; and proteolysis. Predicted to be active in cytoplasm. Orthologous to human TASP1 (taspase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 6.1), CNS E18 (RPKM 2.2) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 F3; 2 69.2 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (139675399..139908767, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (139833479..140066847, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene serine palmitoyltransferase, long chain base subunit 3 Neighboring gene STARR-seq mESC enhancer starr_05833 Neighboring gene STARR-seq mESC enhancer starr_05835 Neighboring gene STARR-seq mESC enhancer starr_05836 Neighboring gene isthmin 1, angiogenesis inhibitor Neighboring gene STARR-seq mESC enhancer starr_05837 Neighboring gene STARR-seq mESC enhancer starr_05838 Neighboring gene STARR-seq mESC enhancer starr_05839 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:139750776-139750959 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:139760469-139760763 Neighboring gene STARR-positive B cell enhancer mm9_chr2:139792158-139792459 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:139867947-139868134 Neighboring gene STARR-positive B cell enhancer ABC_E4503 Neighboring gene STARR-seq mESC enhancer starr_05842 Neighboring gene ribosomal protein S19, pseudogene 7 Neighboring gene STARR-positive B cell enhancer ABC_E4504 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:139996213-139996396 Neighboring gene ESF1 nucleolar pre-rRNA processing protein homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A pharmacologic inhibitor of the protease Taspase1 effectively inhibits breast and brain tumor growth. Chen DY, et al. Cancer Res, 2012 Feb 1. PMID 22166309, Free PMC Article
  2. Regulation of MLL/COMPASS stability through its proteolytic cleavage by taspase1 as a possible approach for clinical therapy of leukemia. Zhao Z, et al. Genes Dev, 2019 Jan 1. PMID 30573454, Free PMC Article
  3. Taspase1 cleaves MLL1 to activate cyclin E for HER2/neu breast tumorigenesis. Dong Y, et al. Cell Res, 2014 Nov. PMID 25267403, Free PMC Article
  4. Taspase1 orchestrates fetal liver hematopoietic stem cell and vertebrae fates by cleaving TFIIA. Niizuma H, et al. JCI Insight, 2021 Aug 9. PMID 34156981, Free PMC Article
  5. Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs. Oyama T, et al. Dev Cell, 2013 Oct 28. PMID 24176642, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upon loss of taspase1, MLL1 association with chromatin is markedly increased due to the stabilization of its unprocessed version, and this stabilization of the uncleaved MLL1 can result in the displacement of MLL chimeras from chromatin in leukemic cells
    Title: Regulation of MLL/COMPASS stability through its proteolytic cleavage by taspase1 as a possible approach for clinical therapy of leukemia.
  2. Taspase1 deficiency disrupts the expression of cyclins and proliferation of HER2+ breast cancer cells.
    Title: Taspase1 cleaves MLL1 to activate cyclin E for HER2/neu breast tumorigenesis.
  3. TFIIA is the principal TASP1 substrate that orchestrates craniofacial morphogenesis.
    Title: Taspase1-dependent TFIIA cleavage coordinates head morphogenesis by limiting Cdkn2a locus transcription.
  4. Taspase1 cleaves a ubiquitously expressed GTF (TFIIA) to enable tissue-specific (testis) transcription, meeting the demand for sophisticated regulation of distinct subsets of genes in higher organisms.
    Title: Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs.
  5. TASP1, EPS15R, and PRPF3 expression were significantly induced in HCCs of transgenic EGF2B mice as was P2 promoter-driven HNF4alpha
    Title: EPS15R, TASP1, and PRPF3 are novel disease candidate genes targeted by HNF4alpha splice variants in hepatocellular carcinomas.
  6. This paper describes the quintessential function of Taspase1 in orchestrating cell cycle progression.
    Title: Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables threonine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables threonine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables threonine-type endopeptidase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in protein maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
threonine aspartase 1
Names
taspase-1
NP_001153112.1
NP_001153113.1
NP_001276540.1
NP_780434.1
XP_011238131.1
XP_017174798.1
XP_017174799.1
XP_017174800.1
XP_017174801.1
XP_017174802.1
XP_017174803.1
XP_017174804.1
XP_030108031.1
XP_030108032.1
XP_030108033.1
XP_030108034.1
XP_030108035.1
XP_030108036.1
XP_036018549.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159640.2 → NP_001153112.1  threonine aspartase 1 isoform a

    See identical proteins and their annotated locations for NP_001153112.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AK015624, BB791136, BC024597
    Consensus CDS
    CCDS16802.1
    UniProtKB/Swiss-Prot
    Q8R1G1, Q99JP3
    Related
    ENSMUSP00000105706.3, ENSMUST00000110079.9
    Conserved Domains (1) summary
    cd04514
    Location:42 → 416
    Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins

  2. NM_001159641.2 → NP_001153113.1  threonine aspartase 1 isoform b

    See identical proteins and their annotated locations for NP_001153113.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (b) is shorter than isoform a.
    Source sequence(s)
    AK015624, AK036512, AK132709, BB791136
    Consensus CDS
    CCDS50731.1
    UniProtKB/TrEMBL
    Q3UJT0
    Related
    ENSMUSP00000096907.4, ENSMUST00000099304.4
    Conserved Domains (1) summary
    cd04514
    Location:42 → 379
    Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins

  3. NM_001289611.1 → NP_001276540.1  threonine aspartase 1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains a 3' terminal exon which extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform c, which is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AI662572, AK015624, AK050603, BB665115
    UniProtKB/Swiss-Prot
    Q8R1G1
    Conserved Domains (1) summary
    cd04514
    Location:42 → 162
    Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins

  4. NM_175225.5 → NP_780434.1  threonine aspartase 1 isoform a

    See identical proteins and their annotated locations for NP_780434.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AK015624, AK036512, BB791136
    Consensus CDS
    CCDS16802.1
    UniProtKB/Swiss-Prot
    Q8R1G1, Q99JP3
    Related
    ENSMUSP00000039546.3, ENSMUST00000046656.9
    Conserved Domains (1) summary
    cd04514
    Location:42 → 416
    Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins

RNA

  1. NR_110350.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an internal exon and uses an alternate splice site in a internal exon, compare to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK015624, AK160983, BB791136

  2. NR_110351.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK015624, AK160983, BB791136

  3. NR_110352.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, lacks an internal exon and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK015624, AK132709, BB791136

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    139675399..139908767 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319311.1 → XP_017174800.1  threonine aspartase 1 isoform X4

    Conserved Domains (1) summary
    cd04514
    Location:42 → 393
    Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins

  2. XM_017319312.2 → XP_017174801.1  threonine aspartase 1 isoform X6

    Conserved Domains (1) summary
    cd04514
    Location:42 → 349
    Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins

  3. XM_017319310.2 → XP_017174799.1  threonine aspartase 1 isoform X3

    Conserved Domains (1) summary
    cd04514
    Location:42 → 402
    Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins

  4. XM_011239829.3 → XP_011238131.1  threonine aspartase 1 isoform X1

    Conserved Domains (1) summary
    cd04514
    Location:42 → 439
    Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins

  5. XM_030252176.2 → XP_030108036.1  threonine aspartase 1 isoform X9

    Conserved Domains (1) summary
    cd04514
    Location:38 → 230
    Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins

  6. XM_030252175.2 → XP_030108035.1  threonine aspartase 1 isoform X8

    Conserved Domains (1) summary
    cd04514
    Location:1 → 260
    Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins

  7. XM_017319314.3 → XP_017174803.1  threonine aspartase 1 isoform X7

    Conserved Domains (1) summary
    cd04514
    Location:1 → 297
    Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins

  8. XM_030252174.2 → XP_030108034.1  threonine aspartase 1 isoform X6

    Conserved Domains (1) summary
    cd04514
    Location:42 → 349
    Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins

  9. XM_030252173.2 → XP_030108033.1  threonine aspartase 1 isoform X5

    UniProtKB/TrEMBL
    Q3UJT0
    Conserved Domains (1) summary
    cd04514
    Location:42 → 379
    Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins

  10. XM_036162656.1 → XP_036018549.1  threonine aspartase 1 isoform X4

    Conserved Domains (1) summary
    cd04514
    Location:42 → 393
    Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins

  11. XM_017319309.2 → XP_017174798.1  threonine aspartase 1 isoform X1

    Conserved Domains (1) summary
    cd04514
    Location:42 → 439
    Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins

  12. XM_017319315.3 → XP_017174804.1  threonine aspartase 1 isoform X9

    Conserved Domains (1) summary
    cd04514
    Location:38 → 230
    Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins

  13. XM_017319313.3 → XP_017174802.1  threonine aspartase 1 isoform X7

    Conserved Domains (1) summary
    cd04514
    Location:1 → 297
    Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins

  14. XM_030252171.2 → XP_030108031.1  threonine aspartase 1 isoform X1

    Conserved Domains (1) summary
    cd04514
    Location:42 → 439
    Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins

  15. XM_030252172.2 → XP_030108032.1  threonine aspartase 1 isoform X2

    UniProtKB/Swiss-Prot
    Q8R1G1, Q99JP3
    Conserved Domains (1) summary
    cd04514
    Location:42 → 416
    Taspase1_like; Taspase 1 (threonine aspartase 1) and similar proteins

RNA

  1. XR_866347.3 RNA Sequence

  2. XR_866346.3 RNA Sequence

  3. XR_003953732.1 RNA Sequence

  4. XR_001783198.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R1G1.1 GenPept UniProtKB/Swiss-Prot:Q8R1G1

Gene LinkOut

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