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Klhl24 kelch-like 24 [ Mus musculus (house mouse) ]

Gene ID: 75785, updated on 5-Mar-2024

Summary

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Official Symbol
Klhl24provided by MGI
Official Full Name
kelch-like 24provided by MGI
Primary source
MGI:MGI:1923035
See related
Ensembl:ENSMUSG00000062901 AllianceGenome:MGI:1923035
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110046J11Rik; 4930429H24Rik; 6530402O20Rik
Summary
Predicted to be involved in intermediate filament organization and protein autoubiquitination. Predicted to be located in adherens junction; cytoplasm; and desmosome. Predicted to be part of Cul3-RING ubiquitin ligase complex. Is expressed in central nervous system; ganglia; and olfactory epithelium. Orthologous to human KLHL24 (kelch like family member 24). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 15.9), bladder adult (RPKM 11.6) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Klhl24 in Genome Data Viewer
Location:
16 A3; 16 12.36 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (19916286..19947976)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (20097553..20129226)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A930003A15 gene Neighboring gene STARR-seq mESC enhancer starr_40308 Neighboring gene kelch-like 6 Neighboring gene STARR-seq mESC enhancer starr_40309 Neighboring gene STARR-positive B cell enhancer ABC_E2456 Neighboring gene STARR-positive B cell enhancer ABC_E1183 Neighboring gene YEATS domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_40314 Neighboring gene SMT3 suppressor of mif two 3 homolog 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40316 Neighboring gene predicted gene, 41431 Neighboring gene MAP6 domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Excess KLHL24 Impairs Skin Wound Healing through the Degradation of Vimentin. Liu Y, et al. J Invest Dermatol, 2023 Jul. PMID 36716923
  2. KLHL24-Mediated Hair Follicle Stem Cells Structural Disruption Causes Alopecia. Cui J, et al. J Invest Dermatol, 2022 Aug. PMID 35066002
  3. Stabilizing mutations of KLHL24 ubiquitin ligase cause loss of keratin 14 and human skin fragility. Lin Z, et al. Nat Genet, 2016 Dec. PMID 27798626
  4. KRIP6: a novel BTB/kelch protein regulating function of kainate receptors. Laezza F, et al. Mol Cell Neurosci, 2007 Apr. PMID 17254796, Free PMC Article
  5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Excess KLHL24 Impairs Skin Wound Healing through the Degradation of Vimentin.
    Title: Excess KLHL24 Impairs Skin Wound Healing through the Degradation of Vimentin.
  2. KLHL24-Mediated Hair Follicle Stem Cells Structural Disruption Causes Alopecia.
    Title: KLHL24-Mediated Hair Follicle Stem Cells Structural Disruption Causes Alopecia.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in intermediate filament organization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of kainate selective glutamate receptor activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in desmosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kelch-like protein 24
Names
KRIP6
kainate receptor-interacting protein for GluR6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029436.3 → NP_083712.4  kelch-like protein 24

    See identical proteins and their annotated locations for NP_083712.4

    Status: VALIDATED

    Source sequence(s)
    AC165282
    Consensus CDS
    CCDS28042.1
    UniProtKB/Swiss-Prot
    Q3TQG0, Q78J30, Q8BQU1, Q8BRG6, Q9D5K3
    Related
    ENSMUSP00000023509.4, ENSMUST00000023509.5
    Conserved Domains (4) summary
    smart00612
    Location:545 → 591
    Kelch; Kelch domain
    PHA03098
    Location:62 → 566
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:354 → 393
    Kelch; KELCH repeat [structural motif]
    cd18253
    Location:48 → 168
    BTB_POZ_KLHL24_KRIP6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    19916286..19947976
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522687.5 → XP_006522750.1  kelch-like protein 24 isoform X1

    See identical proteins and their annotated locations for XP_006522750.1

    UniProtKB/Swiss-Prot
    Q3TQG0, Q78J30, Q8BQU1, Q8BRG6, Q9D5K3
    Conserved Domains (4) summary
    smart00612
    Location:545 → 591
    Kelch; Kelch domain
    PHA03098
    Location:62 → 566
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:354 → 393
    Kelch; KELCH repeat [structural motif]
    cd18253
    Location:48 → 168
    BTB_POZ_KLHL24_KRIP6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24)

  2. XM_036160174.1 → XP_036016067.1  kelch-like protein 24 isoform X1

    UniProtKB/Swiss-Prot
    Q3TQG0, Q78J30, Q8BQU1, Q8BRG6, Q9D5K3
    Conserved Domains (4) summary
    smart00612
    Location:545 → 591
    Kelch; Kelch domain
    PHA03098
    Location:62 → 566
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:354 → 393
    Kelch; KELCH repeat [structural motif]
    cd18253
    Location:48 → 168
    BTB_POZ_KLHL24_KRIP6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24)

RNA

  1. XR_004939253.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BRG6.2 GenPept UniProtKB/Swiss-Prot:Q8BRG6

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