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Adad2 adenosine deaminase domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 75773, updated on 21-Apr-2024

Summary

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Official Symbol
Adad2provided by MGI
Official Full Name
adenosine deaminase domain containing 2provided by MGI
Primary source
MGI:MGI:1923023
See related
Ensembl:ENSMUSG00000024266 AllianceGenome:MGI:1923023
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930403J07Rik
Summary
Predicted to enable double-stranded RNA adenosine deaminase activity; double-stranded RNA binding activity; and tRNA-specific adenosine deaminase activity. Predicted to be involved in RNA processing and adenosine to inosine editing. Predicted to be active in cytoplasm and nucleolus. Is expressed in central nervous system; olfactory epithelium; and testis. Orthologous to human ADAD2 (adenosine deaminase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 24.1) and duodenum adult (RPKM 1.4) See more
Orthologs
human all
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Genomic context

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Location:
8 E1; 8 68.05 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (120339449..120343665)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (119612710..119616926)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene dynein, axonemal assembly factor 1 Neighboring gene STARR-seq mESC enhancer starr_22854 Neighboring gene STARR-seq mESC enhancer starr_22855 Neighboring gene TATA-box binding protein associated factor, RNA polymerase I, C Neighboring gene ribosomal protein S13, pseudogene 4 Neighboring gene STARR-positive B cell enhancer ABC_E1772 Neighboring gene STARR-seq mESC enhancer starr_22857 Neighboring gene potassium voltage-gated channel, subfamily G, member 4 Neighboring gene predicted gene, 46055 Neighboring gene predicted gene, 46054

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ADAD2 interacts with RNF17 in P-bodies to repress the Ping-pong cycle in pachytene piRNA biogenesis. Xiong M, et al. J Cell Biol, 2023 May 1. PMID 36930220, Free PMC Article
  2. ADAD2 functions in spermiogenesis and piRNA biogenesis in mice. Lu Y, et al. Andrology, 2023 May. PMID 36698249,
  3. ADAD1 and ADAD2, testis-specific adenosine deaminase domain-containing proteins, are required for male fertility. Snyder E, et al. Sci Rep, 2020 Jul 14. PMID 32665638, Free PMC Article
  4. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
  5. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Two RNA binding proteins, ADAD2 and RNF17, interact to form a heterogeneous population of novel meiotic germ cell granules with developmentally dependent organelle association.
    Title: Two RNA binding proteins, ADAD2 and RNF17, interact to form a heterogeneous population of novel meiotic germ cell granules with developmentally dependent organelle association.
  2. ADAD2 functions in spermiogenesis and piRNA biogenesis in mice.
    Title: ADAD2 functions in spermiogenesis and piRNA biogenesis in mice.
  3. ADAD1 and ADAD2, testis-specific adenosine deaminase domain-containing proteins, are required for male fertility.
    Title: ADAD1 and ADAD2, testis-specific adenosine deaminase domain-containing proteins, are required for male fertility.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables adenosine deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded RNA adenosine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA-specific adenosine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenosine to inosine editing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
adenosine deaminase domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029428.2 → NP_083704.1  adenosine deaminase domain-containing protein 2

    See identical proteins and their annotated locations for NP_083704.1

    Status: VALIDATED

    Source sequence(s)
    AC104882
    Consensus CDS
    CCDS52683.1
    UniProtKB/Swiss-Prot
    B2RQL4, Q9D5P4
    Related
    ENSMUSP00000095964.3, ENSMUST00000098361.4
    Conserved Domains (2) summary
    cd00048
    Location:101 → 157
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam02137
    Location:239 → 554
    A_deamin; Adenosine-deaminase (editase) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    120339449..120343665
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531467.2 → XP_006531530.1  adenosine deaminase domain-containing protein 2 isoform X2

    Conserved Domains (2) summary
    cl00054
    Location:90 → 157
    DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
    cl02661
    Location:239 → 272
    A_deamin; Adenosine-deaminase (editase) domain

  2. XM_006531464.2 → XP_006531527.1  adenosine deaminase domain-containing protein 2 isoform X1

    Conserved Domains (2) summary
    cl00054
    Location:90 → 157
    DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
    cl02661
    Location:239 → 488
    A_deamin; Adenosine-deaminase (editase) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D5P4.2 GenPept UniProtKB/Swiss-Prot:Q9D5P4

Gene LinkOut

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