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Ipo4 importin 4 [ Mus musculus (house mouse) ]

Gene ID: 75751, updated on 11-Apr-2024

Summary

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Official Symbol
Ipo4provided by MGI
Official Full Name
importin 4provided by MGI
Primary source
MGI:MGI:1923001
See related
Ensembl:ENSMUSG00000002319 AllianceGenome:MGI:1923001
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Imp4a; RanBP4; 8430408O15Rik
Summary
Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in DNA replication-dependent chromatin assembly; DNA replication-independent chromatin assembly; and protein import into nucleus. Predicted to act upstream of or within ribosome biogenesis. Predicted to be located in chromatin. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Is expressed in retina outer nuclear layer. Orthologous to human IPO4 (importin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 123.0), ovary adult (RPKM 46.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 C3; 14 28.19 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55862857..55873321, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55625400..55635868, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:56222707-56223021 Neighboring gene interferon regulatory factor 9 Neighboring gene REC8 meiotic recombination protein Neighboring gene transmembrane 9 superfamily member 1 Neighboring gene testis-specific serine kinase 4 Neighboring gene magnesium-dependent phosphatase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Distinct effects of importin α2 and α4 on Oct3/4 localization and expression in mouse embryonic stem cells. Young JC, et al. FASEB J, 2011 Nov. PMID 21840941
  2. Involvement of importin-4 in the transport of transition protein 2 into the spermatid nucleus. Pradeepa MM, et al. Mol Cell Biol, 2008 Jul. PMID 17682055, Free PMC Article
  3. CCAAT/enhancer binding protein delta (C/EBPdelta, CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage. Wang J, et al. Proc Natl Acad Sci U S A, 2010 Sep 14. PMID 20805509, Free PMC Article
  4. The role of metallothionein in the pathogenesis of acute lung injury. Wesselkamper SC, et al. Am J Respir Cell Mol Biol, 2006 Jan. PMID 16166738, Free PMC Article
  5. Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains. Jäkel S, et al. EMBO J, 2002 Feb 1. PMID 11823430, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. report a function of IPO4 and nuclear import in the Fanconi anemia pathway of DNA repair
    Title: CCAAT/enhancer binding protein delta (C/EBPdelta, CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage.
  2. Metallothionein deficient mice have a marked decrease in Importin 4 transcripts during acute lung injury
    Title: The role of metallothionein in the pathogenesis of acute lung injury.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC113723

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear import signal receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear localization sequence binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ribosome biogenesis ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
importin-4
Names
imp4
importin 4a
ran-binding protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360078.1 → NP_001347007.1  importin-4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK030490, AK147086, BM950244
    Conserved Domains (3) summary
    smart00913
    Location:24 → 90
    IBN_N; Importin-beta N-terminal domain
    COG5215
    Location:353 → 620
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:353 → 381
    HEAT; HEAT repeat [structural motif]

  2. NM_024267.7 → NP_077229.4  importin-4 isoform 1

    See identical proteins and their annotated locations for NP_077229.4

    Status: VALIDATED

    Source sequence(s)
    AK030490, AK147086
    Consensus CDS
    CCDS27121.1
    UniProtKB/Swiss-Prot
    Q3TBW0, Q8VI75, Q99J52
    Related
    ENSMUSP00000036555.10, ENSMUST00000047131.16
    Conserved Domains (2) summary
    smart00913
    Location:24 → 90
    IBN_N; Importin-beta N-terminal domain
    sd00044
    Location:353 → 381
    HEAT; HEAT repeat [structural motif]

RNA

  1. NR_153401.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK030490, AK147086, BC085150
    Related
    ENSMUST00000135221.8

  2. NR_153402.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK018399, AK030490, AK147086
    Related
    ENSMUST00000148351.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    55862857..55873321 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316220.3 → XP_017171709.1  importin-4 isoform X1

    Conserved Domains (2) summary
    COG5215
    Location:153 → 420
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:153 → 181
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VI75.1 GenPept UniProtKB/Swiss-Prot:Q8VI75

Gene LinkOut

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