U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Slc10a6 solute carrier family 10 (sodium/bile acid cotransporter family), member 6 [ Mus musculus (house mouse) ]

Gene ID: 75750, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Slc10a6provided by MGI
Official Full Name
solute carrier family 10 (sodium/bile acid cotransporter family), member 6provided by MGI
Primary source
MGI:MGI:1923000
See related
Ensembl:ENSMUSG00000029321 AllianceGenome:MGI:1923000
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Soat; 8430417G17Rik
Summary
Predicted to enable bile acid:sodium symporter activity and sodium-dependent organic anion transmembrane transporter activity. Predicted to be involved in bile acid and bile salt transport and sodium-dependent organic anion transport. Predicted to act upstream of or within sodium ion transport. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in metanephros. Orthologous to human SLC10A6 (solute carrier family 10 member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 9.0), subcutaneous fat pad adult (RPKM 3.7) and 7 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
5 E5; 5 50.45 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (103753583..103777152, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (103605711..103629403, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30443 Neighboring gene protein tyrosine phosphatase, non-receptor type 13 Neighboring gene RIKEN cDNA 1700016H13 gene Neighboring gene STARR-seq mESC enhancer starr_13780 Neighboring gene predicted gene, 42138 Neighboring gene predicted gene, 25721

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Sodium-dependent organic anion transporter (Slc10a6(-/-)) knockout mice show normal spermatogenesis and reproduction, but elevated serum levels for cholesterol sulfate. Bakhaus K, et al. J Steroid Biochem Mol Biol, 2018 May. PMID 28743544
  2. Cloning and functional characterization of the mouse sodium-dependent organic anion transporter Soat (Slc10a6). Grosser G, et al. J Steroid Biochem Mol Biol, 2013 Nov. PMID 23562556
  3. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831
  4. The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease. Willnow T, et al. Organogenesis, 2005 Apr. PMID 19521566, Free PMC Article
  5. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Slc10a6 role in the supply of steroids in the testis and consequently for spermatogenesis and fertility.
    Title: Sodium-dependent organic anion transporter (Slc10a6(-/-)) knockout mice show normal spermatogenesis and reproduction, but elevated serum levels for cholesterol sulfate.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC149979

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables bile acid:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium-dependent organic anion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in bile acid and bile salt transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium-dependent organic anion transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
sodium-dependent organic anion transporter
Names
solute carrier family 10 member 6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029415.3 → NP_083691.1  sodium-dependent organic anion transporter

    See identical proteins and their annotated locations for NP_083691.1

    Status: VALIDATED

    Source sequence(s)
    AC161169
    Consensus CDS
    CCDS19477.1
    UniProtKB/Swiss-Prot
    B2RTH4, Q9CXB2
    Related
    ENSMUSP00000031263.2, ENSMUST00000031263.2
    Conserved Domains (1) summary
    TIGR00841
    Location:32 → 312
    bass; bile acid transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    103753583..103777152 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535278.4 → XP_006535341.1  sodium-dependent organic anion transporter isoform X1

    Conserved Domains (1) summary
    cl19217
    Location:1 → 184
    SBF; Sodium Bile acid symporter family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CXB2.1 GenPept UniProtKB/Swiss-Prot:Q9CXB2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous