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Egfem1 EGF-like and EMI domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 75740, updated on 8-Feb-2024

Summary

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Official Symbol
Egfem1provided by MGI
Official Full Name
EGF-like and EMI domain containing 1provided by MGI
Primary source
MGI:MGI:1922990
See related
Ensembl:ENSMUSG00000063600 AllianceGenome:MGI:1922990
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Efcab11; 6130401L20Rik
Summary
Predicted to enable calcium ion binding activity. Orthologous to human EGFEM1P (EGF like and EMI domain containing 1, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 1.1), frontal lobe adult (RPKM 0.9) and 10 other tissues See more
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Genomic context

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Location:
3 A3; 3 12.57 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (29135695..29831923)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (29081653..29691058)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07272 Neighboring gene predicted gene, 33102 Neighboring gene STARR-seq mESC enhancer starr_07273 Neighboring gene predicted gene 1527 Neighboring gene STARR-seq mESC enhancer starr_07274 Neighboring gene predicted gene, 33154 Neighboring gene STARR-seq mESC enhancer starr_07276 Neighboring gene STARR-seq mESC enhancer starr_07277 Neighboring gene STARR-seq mESC enhancer starr_07278 Neighboring gene microRNA 551b Neighboring gene STARR-seq mESC enhancer starr_07280 Neighboring gene STARR-seq mESC enhancer starr_07281 Neighboring gene STARR-seq mESC enhancer starr_07282 Neighboring gene microRNA 21b Neighboring gene predicted gene, 42197 Neighboring gene STARR-seq mESC enhancer starr_07283 Neighboring gene STARR-seq mESC enhancer starr_07284 Neighboring gene predicted gene, 33206 Neighboring gene STARR-seq mESC enhancer starr_07285 Neighboring gene Mecom adjacent non-protein coding RNA Neighboring gene MDS1 and EVI1 complex locus Neighboring gene predicted gene, 52621

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Novel candidate genes for impaired nephron development in a rat model with inherited nephron deficit and albuminuria. Herlan L, et al. Clin Exp Pharmacol Physiol, 2015 Oct. PMID 26192016
  2. Molecular architecture of the developing mouse brain. La Manno G, et al. Nature, 2021 Aug. PMID 34321664
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
EGF-like and EMI domain-containing protein 1
Names
EF-hand calcium binding domain 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167748.3 → NP_001161220.1  EGF-like and EMI domain-containing protein 1 isoform b precursor

    Status: VALIDATED

    Source sequence(s)
    AC110222, AC119240, AL691427
    Consensus CDS
    CCDS50882.1
    UniProtKB/Swiss-Prot
    B7ZCE8, Q149G1, Q8C088
    Related
    ENSMUSP00000112907.2, ENSMUST00000118531.8
    Conserved Domains (2) summary
    pfam14670
    Location:238 → 273
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:174 → 226
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  2. NM_001357198.2 → NP_001344127.1  EGF-like and EMI domain-containing protein 1 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AC110222, AC119240, AL691427
    UniProtKB/Swiss-Prot
    B7ZCE8, Q149G1, Q8C088
    Conserved Domains (2) summary
    pfam14670
    Location:319 → 354
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:264 → 306
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  3. NM_029412.3 → NP_083688.1  EGF-like and EMI domain-containing protein 1 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC110222, AC113454, AC119240, AL691427
    Consensus CDS
    CCDS50881.1
    UniProtKB/Swiss-Prot
    B7ZCE8, Q149G1, Q8C088
    UniProtKB/TrEMBL
    B7ZCE7
    Related
    ENSMUSP00000112943.2, ENSMUST00000119598.8
    Conserved Domains (2) summary
    pfam14670
    Location:295 → 330
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:240 → 282
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RNA

  1. NR_151636.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC110222, AC119240, AL691427

  2. NR_151637.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC110222, AC119240, AL691427

  3. NR_151638.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC110222, AC119240, AL691427

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    29135695..29831923
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163372.1 → XP_036019265.1  EGF-like and EMI domain-containing protein 1 isoform X2

    UniProtKB/Swiss-Prot
    B7ZCE8, Q149G1, Q8C088
    Conserved Domains (2) summary
    pfam14670
    Location:363 → 398
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:308 → 350
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  2. XM_006535559.5 → XP_006535622.1  EGF-like and EMI domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B7ZCE8, Q149G1, Q8C088
    Conserved Domains (3) summary
    pfam07546
    Location:71 → 140
    EMI; EMI domain
    pfam14670
    Location:363 → 398
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:308 → 350
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  3. XM_017319785.3 → XP_017175274.1  EGF-like and EMI domain-containing protein 1 isoform X6

    UniProtKB/Swiss-Prot
    B7ZCE8, Q149G1, Q8C088
    Conserved Domains (3) summary
    pfam07546
    Location:71 → 140
    EMI; EMI domain
    pfam14670
    Location:363 → 398
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:308 → 350
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  4. XM_017319784.3 → XP_017175273.1  EGF-like and EMI domain-containing protein 1 isoform X3

    Conserved Domains (3) summary
    pfam07546
    Location:71 → 140
    EMI; EMI domain
    pfam14670
    Location:358 → 393
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:303 → 345
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  5. XM_017319788.3 → XP_017175277.1  EGF-like and EMI domain-containing protein 1 isoform X10

    UniProtKB/Swiss-Prot
    B7ZCE8, Q149G1, Q8C088
    Conserved Domains (3) summary
    pfam07546
    Location:71 → 140
    EMI; EMI domain
    pfam14670
    Location:277 → 312
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:213 → 265
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  6. XM_017319789.3 → XP_017175278.1  EGF-like and EMI domain-containing protein 1 isoform X11

    Conserved Domains (2) summary
    pfam07546
    Location:71 → 140
    EMI; EMI domain
    pfam14670
    Location:277 → 312
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  7. XM_006535562.5 → XP_006535625.1  EGF-like and EMI domain-containing protein 1 isoform X5

    UniProtKB/Swiss-Prot
    B7ZCE8, Q149G1, Q8C088
    Conserved Domains (3) summary
    pfam07546
    Location:71 → 140
    EMI; EMI domain
    pfam14670
    Location:322 → 357
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:267 → 309
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  8. XM_006535561.4 → XP_006535624.1  EGF-like and EMI domain-containing protein 1 isoform X4

    UniProtKB/Swiss-Prot
    B7ZCE8, Q149G1, Q8C088
    Conserved Domains (3) summary
    pfam07546
    Location:32 → 101
    EMI; EMI domain
    pfam14670
    Location:324 → 359
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:269 → 311
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  9. XM_006535563.4 → XP_006535626.1  EGF-like and EMI domain-containing protein 1 isoform X7

    UniProtKB/Swiss-Prot
    B7ZCE8, Q149G1, Q8C088
    Conserved Domains (3) summary
    pfam07546
    Location:32 → 101
    EMI; EMI domain
    pfam14670
    Location:319 → 354
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:264 → 306
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  10. XM_036163373.1 → XP_036019266.1  EGF-like and EMI domain-containing protein 1 isoform X8

    UniProtKB/Swiss-Prot
    B7ZCE8, Q149G1, Q8C088
    Conserved Domains (2) summary
    pfam14670
    Location:283 → 318
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:228 → 270
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  11. XM_036163375.1 → XP_036019268.1  EGF-like and EMI domain-containing protein 1 isoform X9

    UniProtKB/Swiss-Prot
    B7ZCE8, Q149G1, Q8C088
    Conserved Domains (2) summary
    pfam14670
    Location:278 → 313
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:223 → 265
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  12. XM_036163376.1 → XP_036019269.1  EGF-like and EMI domain-containing protein 1 isoform X13

    UniProtKB/Swiss-Prot
    B7ZCE8, Q149G1, Q8C088
    Conserved Domains (2) summary
    pfam14670
    Location:197 → 232
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:229 → 270
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  13. XM_006535565.2 → XP_006535628.1  EGF-like and EMI domain-containing protein 1 isoform X12

    See identical proteins and their annotated locations for XP_006535628.1

    UniProtKB/TrEMBL
    Q9CXD8
    Conserved Domains (3) summary
    pfam07546
    Location:32 → 101
    EMI; EMI domain
    pfam14670
    Location:319 → 354
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:264 → 306
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  14. XM_036163377.1 → XP_036019270.1  EGF-like and EMI domain-containing protein 1 isoform X14

    Conserved Domains (3) summary
    pfam12662
    Location:3 → 24
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:71 → 106
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:16 → 58
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  15. XM_030252865.1 → XP_030108725.1  EGF-like and EMI domain-containing protein 1 isoform X14

    Conserved Domains (3) summary
    pfam12662
    Location:3 → 24
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:71 → 106
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:16 → 58
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  16. XM_030252867.2 → XP_030108727.1  EGF-like and EMI domain-containing protein 1 isoform X14

    Conserved Domains (3) summary
    pfam12662
    Location:3 → 24
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:71 → 106
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:16 → 58
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  17. XM_017319790.2 → XP_017175279.1  EGF-like and EMI domain-containing protein 1 isoform X14

    Conserved Domains (3) summary
    pfam12662
    Location:3 → 24
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:71 → 106
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:16 → 58
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RNA

  1. XR_001783766.3 RNA Sequence

  2. XR_003954418.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C088.1 GenPept UniProtKB/Swiss-Prot:Q8C088

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