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ZNF26 zinc finger protein 26 [ Homo sapiens (human) ]

Gene ID: 7574, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF26provided by HGNC
Official Full Name
zinc finger protein 26provided by HGNC
Primary source
HGNC:HGNC:13053
See related
Ensembl:ENSG00000198393 MIM:194537; AllianceGenome:HGNC:13053
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KOX20; HEL-179
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 2.0), lymph node (RPKM 1.7) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF26 in Genome Data Viewer
Location:
12q24.33
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (132986367..133027102)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (133043702..133084435)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (133562953..133603688)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 605 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:133531610-133532440 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:133532441-133533269 Neighboring gene uncharacterized LOC124903064 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:133553507-133553757 Neighboring gene NANOGNB pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7395 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:133563299-133563798 Neighboring gene RNA, U4atac small nuclear 12, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7397 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5134 Neighboring gene ZNF84 divergent transcript Neighboring gene PTP4A1 pseudogene 2 Neighboring gene zinc finger protein 84 Neighboring gene MPRA-validated peak2056 silencer

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Two human genes encoding zinc finger proteins, ZNF 12 (KOX 3) and ZNF 26 (KOX 20), map to chromosome 7p22-p21 and 12q24.33, respectively. Seite P, et al. Hum Genet, 1991 Apr. PMID 2026422
  2. Multiple genes encoding zinc finger domains are expressed in human T cells. Thiesen HJ. New Biol, 1990 Apr. PMID 2288909
  3. Microtubule-associated proteins 1 (MAP1) promote human immunodeficiency virus type I (HIV-1) intracytoplasmic routing to the nucleus. Fernandez J, et al. J Biol Chem, 2015 Feb 20. PMID 25505242, Free PMC Article
  4. POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1. Wang B, et al. EBioMedicine, 2019 Mar. PMID 30745168, Free PMC Article
  5. A census of human transcription factors: function, expression and evolution. Vaquerizas JM, et al. Nat Rev Genet, 2009 Apr. PMID 19274049

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
capsid gag The interaction of HIV-1 CA with human cellular zinc finger protein 26 (ZNF26) is identified by yeast two-hybrid screen PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20755

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 26
Names
epididymis luminal protein 179
zinc finger protein KOX20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256279.2 → NP_001243208.1  zinc finger protein 26 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC073911
    Conserved Domains (5) summary
    smart00349
    Location:47 → 107
    KRAB; krueppel associated box
    COG5048
    Location:209 → 557
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:489 → 509
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:47 → 86
    KRAB; KRAB box
    pfam13465
    Location:501 → 526
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001256280.2 → NP_001243209.1  zinc finger protein 26 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC073911
    Conserved Domains (5) summary
    smart00349
    Location:14 → 54
    KRAB; krueppel associated box
    COG5048
    Location:144 → 492
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:424 → 444
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:436 → 461
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001330513.2 → NP_001317442.1  zinc finger protein 26 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR and lacks an alternate exon in the 5' coding region compared to variant 1. This variant represents translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream start codon to encode an isoform (4) that has a shorter N-terminus, compared to isoform 1. Variants 4 and 5 encode the same isoform (4).
    Source sequence(s)
    AC073911, BM718210, DA022426, DA107937, DA737586, DB239332, EU668356
    UniProtKB/TrEMBL
    F5H6R4, V9HW07

  4. NM_001330514.2 → NP_001317443.1  zinc finger protein 26 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in its 5' UTR and lacks an alternate exon in the 5' coding region compared to variant 1. This variant represents translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream start codon to encode an isoform (4) that has a shorter N-terminus, compared to isoform 1. Variants 4 and 5 encode the same isoform (4).
    Source sequence(s)
    AC073911, BM718210, DA107937, DA737586, DB232386, EU668356
    UniProtKB/TrEMBL
    F5H6R4, V9HW07

  5. NM_019591.4 → NP_062537.2  zinc finger protein 26 isoform 2

    See identical proteins and their annotated locations for NP_062537.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC073911
    Consensus CDS
    CCDS31939.1
    UniProtKB/Swiss-Prot
    P17031, Q86X57, Q9NWL3
    UniProtKB/TrEMBL
    V9HW07
    Related
    ENSP00000333725.5, ENST00000328654.10
    Conserved Domains (3) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:200 → 512
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:456 → 476
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    132986367..133027102
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047429502.1 → XP_047285458.1  zinc finger protein 26 isoform X1

  2. XM_047429503.1 → XP_047285459.1  zinc finger protein 26 isoform X2

RNA

  1. XR_007063124.1 RNA Sequence

  2. XR_007063123.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    133043702..133084435
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373134.1 → XP_054229109.1  zinc finger protein 26 isoform X2

RNA

  1. XR_008488676.1 RNA Sequence

  2. XR_008488675.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17031.3 GenPept UniProtKB/Swiss-Prot:P17031

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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