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Mff mitochondrial fission factor [ Mus musculus (house mouse) ]

Gene ID: 75734, updated on 21-Apr-2024

Summary

Official Symbol
Mffprovided by MGI
Official Full Name
mitochondrial fission factorprovided by MGI
Primary source
MGI:MGI:1922984
See related
Ensembl:ENSMUSG00000026150 AllianceGenome:MGI:1922984
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5230400G24Rik
Summary
Predicted to enable protein homodimerization activity. Involved in mitochondrial fission and protein targeting to mitochondrion. Located in mitochondrial outer membrane and peroxisome. Orthologous to human MFF (mitochondrial fission factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 63.2), cerebellum adult (RPKM 48.6) and 28 other tissues See more
Orthologs
NEW
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Genomic context

Location:
1 C5; 1 42.45 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (82702599..82730111)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (82724890..82752390)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene collagen, type IV, alpha 4 Neighboring gene collagen, type IV, alpha 3 Neighboring gene RIKEN cDNA C430014B12 gene Neighboring gene STARR-seq mESC enhancer starr_01479 Neighboring gene transmembrane 4 L six family member 20 Neighboring gene predicted gene, 19257

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in mitochondrial fission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitochondrial fission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial fragmentation involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial fusion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
involved_in peroxisome fission ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitochondrial fission IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of mitochondrial fission ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in protein targeting to mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein targeting to mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of peroxisome organization ISO
Inferred from Sequence Orthology
more info
 
involved_in release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mitochondrial fission factor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310695.1NP_001297624.1  mitochondrial fission factor isoform 2

    See identical proteins and their annotated locations for NP_001297624.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK017226, AU080386, BC059229
    Consensus CDS
    CCDS78630.1
    UniProtKB/TrEMBL
    E0CYI3
    Related
    ENSMUSP00000072784.6, ENSMUST00000073025.12
    Conserved Domains (1) summary
    pfam05644
    Location:1239
    Miff; Mitochondrial and peroxisomal fission factor Mff
  2. NM_001310697.1NP_001297626.1  mitochondrial fission factor isoform 3

    See identical proteins and their annotated locations for NP_001297626.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK139649, AU080386, BC059229
    Consensus CDS
    CCDS78631.1
    UniProtKB/TrEMBL
    E0CYI3
    Related
    ENSMUSP00000125230.2, ENSMUST00000160786.8
    Conserved Domains (1) summary
    pfam05644
    Location:1238
    Miff; Mitochondrial and peroxisomal fission factor Mff
  3. NM_001310699.1NP_001297628.1  mitochondrial fission factor isoform 4

    See identical proteins and their annotated locations for NP_001297628.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC138214, AU080386, BC059229, CX231761
    Consensus CDS
    CCDS78632.1
    UniProtKB/TrEMBL
    E0CYI3
    Related
    ENSMUSP00000124200.2, ENSMUST00000160972.8
    Conserved Domains (1) summary
    pfam05644
    Location:1218
    Miff; Mitochondrial and peroxisomal fission factor Mff
  4. NM_001372405.1NP_001359334.1  mitochondrial fission factor isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) represents the longest transcript and encodes the longest isoform (5).
    Source sequence(s)
    AC138214
    UniProtKB/TrEMBL
    A0A1S6GWF9
    Conserved Domains (1) summary
    pfam05644
    Location:27317
    Miff; Mitochondrial and peroxisomal fission factor Mff
  5. NM_001372406.1NP_001359335.1  mitochondrial fission factor isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC138214
    UniProtKB/TrEMBL
    A0A1S6GWF9
    Conserved Domains (1) summary
    pfam05644
    Location:1303
    Miff; Mitochondrial and peroxisomal fission factor Mff
  6. NM_001372407.1NP_001359336.1  mitochondrial fission factor isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC138214
    UniProtKB/TrEMBL
    A0A1S6GWF9
    Conserved Domains (1) summary
    pfam05644
    Location:1302
    Miff; Mitochondrial and peroxisomal fission factor Mff
  7. NM_001372408.1NP_001359337.1  mitochondrial fission factor isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC138214
    UniProtKB/TrEMBL
    A0A1S6GWF9
    Conserved Domains (1) summary
    pfam05644
    Location:1292
    Miff; Mitochondrial and peroxisomal fission factor Mff
  8. NM_001372409.1NP_001359338.1  mitochondrial fission factor isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC138214
    UniProtKB/TrEMBL
    E0CYI3
    Conserved Domains (1) summary
    pfam05644
    Location:1272
    Miff; Mitochondrial and peroxisomal fission factor Mff
  9. NM_001372411.1NP_001359340.1  mitochondrial fission factor isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC138214
    UniProtKB/TrEMBL
    E0CYI3
    Conserved Domains (1) summary
    pfam05644
    Location:1271
    Miff; Mitochondrial and peroxisomal fission factor Mff
  10. NM_001372412.1NP_001359341.1  mitochondrial fission factor isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC138214
    UniProtKB/TrEMBL
    F7CTF8
    Conserved Domains (1) summary
    pfam05644
    Location:1250
    Miff; Mitochondrial and peroxisomal fission factor Mff
  11. NM_001372413.1NP_001359342.1  mitochondrial fission factor isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC138214
    UniProtKB/TrEMBL
    F7CTF8
    Related
    ENSMUSP00000125223.2, ENSMUST00000160750.8
    Conserved Domains (1) summary
    pfam05644
    Location:1249
    Miff; Mitochondrial and peroxisomal fission factor Mff
  12. NM_001372414.1NP_001359343.1  mitochondrial fission factor isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC138214
    UniProtKB/TrEMBL
    E0CYI3
    Conserved Domains (1) summary
    pfam05644
    Location:1219
    Miff; Mitochondrial and peroxisomal fission factor Mff
  13. NM_029409.3NP_083685.2  mitochondrial fission factor isoform 1

    See identical proteins and their annotated locations for NP_083685.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AU080386, BC059229
    Consensus CDS
    CCDS15098.1
    UniProtKB/Swiss-Prot
    Q3UT87, Q6PCP5, Q91VG0, Q9D3P5
    UniProtKB/TrEMBL
    A0A1S6GWF9
    Related
    ENSMUSP00000077446.7, ENSMUST00000078332.13
    Conserved Domains (1) summary
    pfam05644
    Location:1291
    Miff; Mitochondrial and peroxisomal fission factor Mff

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    82702599..82730111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154165.1XP_036010058.1  mitochondrial fission factor isoform X1

    UniProtKB/TrEMBL
    A0A1S6GWF9
    Conserved Domains (1) summary
    pfam05644
    Location:27354
    Miff; Mitochondrial and peroxisomal fission factor Mff
  2. XM_036154176.1XP_036010069.1  mitochondrial fission factor isoform X3

    UniProtKB/TrEMBL
    A0A1S6GWF9
    Conserved Domains (1) summary
    pfam05644
    Location:27343
    Miff; Mitochondrial and peroxisomal fission factor Mff
  3. XM_036154189.1XP_036010082.1  mitochondrial fission factor isoform X9

    UniProtKB/TrEMBL
    A0A1S6GWF9
    Conserved Domains (1) summary
    pfam05644
    Location:27323
    Miff; Mitochondrial and peroxisomal fission factor Mff
  4. XM_006496556.4XP_006496619.1  mitochondrial fission factor isoform X5

    UniProtKB/TrEMBL
    A0A1S6GWF9
    Conserved Domains (1) summary
    pfam05644
    Location:27329
    Miff; Mitochondrial and peroxisomal fission factor Mff
  5. XM_006496558.3XP_006496621.1  mitochondrial fission factor isoform X11

    UniProtKB/TrEMBL
    A0A1S6GWF9
    Conserved Domains (1) summary
    pfam05644
    Location:27318
    Miff; Mitochondrial and peroxisomal fission factor Mff
  6. XM_006496562.4XP_006496625.1  mitochondrial fission factor isoform X14

    UniProtKB/TrEMBL
    A0A1S6GWF9
    Conserved Domains (1) summary
    pfam05644
    Location:27298
    Miff; Mitochondrial and peroxisomal fission factor Mff
  7. XM_006496564.4XP_006496627.1  mitochondrial fission factor isoform X17

    UniProtKB/TrEMBL
    A0A1S6GWF9
    Conserved Domains (1) summary
    pfam05644
    Location:27276
    Miff; Mitochondrial and peroxisomal fission factor Mff
  8. XM_006496566.5XP_006496629.1  mitochondrial fission factor isoform X19

    UniProtKB/TrEMBL
    E0CYI3
    Conserved Domains (1) summary
    pfam05644
    Location:27265
    Miff; Mitochondrial and peroxisomal fission factor Mff
  9. XM_006496568.5XP_006496631.1  mitochondrial fission factor isoform X21

    UniProtKB/TrEMBL
    E0CYI3
    Conserved Domains (1) summary
    pfam05644
    Location:27245
    Miff; Mitochondrial and peroxisomal fission factor Mff
  10. XM_036154172.1XP_036010065.1  mitochondrial fission factor isoform X2

    UniProtKB/TrEMBL
    A0A1S6GWF9
    Conserved Domains (1) summary
    pfam05644
    Location:27353
    Miff; Mitochondrial and peroxisomal fission factor Mff
  11. XM_036154179.1XP_036010072.1  mitochondrial fission factor isoform X4

    UniProtKB/TrEMBL
    A0A1S6GWF9, A0A1S6GWG0
    Conserved Domains (1) summary
    pfam05644
    Location:27342
    Miff; Mitochondrial and peroxisomal fission factor Mff
  12. XM_036154191.1XP_036010084.1  mitochondrial fission factor isoform X10

    UniProtKB/TrEMBL
    A0A1S6GWF9
    Conserved Domains (1) summary
    pfam05644
    Location:27322
    Miff; Mitochondrial and peroxisomal fission factor Mff
  13. XM_006496557.5XP_006496620.1  mitochondrial fission factor isoform X6

    UniProtKB/TrEMBL
    A0A1S6GWF9
    Conserved Domains (1) summary
    pfam05644
    Location:27328
    Miff; Mitochondrial and peroxisomal fission factor Mff
  14. XM_006496563.5XP_006496626.1  mitochondrial fission factor isoform X15

    UniProtKB/TrEMBL
    A0A1S6GWF9
    Conserved Domains (1) summary
    pfam05644
    Location:27297
    Miff; Mitochondrial and peroxisomal fission factor Mff
  15. XM_006496565.5XP_006496628.1  mitochondrial fission factor isoform X18

    UniProtKB/TrEMBL
    A0A1S6GWF9
    Conserved Domains (1) summary
    pfam05644
    Location:27275
    Miff; Mitochondrial and peroxisomal fission factor Mff
  16. XM_006496567.5XP_006496630.1  mitochondrial fission factor isoform X20

    See identical proteins and their annotated locations for XP_006496630.1

    UniProtKB/TrEMBL
    E0CYI3
    Conserved Domains (1) summary
    pfam05644
    Location:27264
    Miff; Mitochondrial and peroxisomal fission factor Mff
  17. XM_006496569.4XP_006496632.1  mitochondrial fission factor isoform X22

    UniProtKB/TrEMBL
    E0CYI3
    Conserved Domains (1) summary
    pfam05644
    Location:27244
    Miff; Mitochondrial and peroxisomal fission factor Mff
  18. XM_036154185.1XP_036010078.1  mitochondrial fission factor isoform X7

    UniProtKB/TrEMBL
    A0A1S6GWF9
    Conserved Domains (1) summary
    pfam05644
    Location:1328
    Miff; Mitochondrial and peroxisomal fission factor Mff
  19. XM_036154192.1XP_036010085.1  mitochondrial fission factor isoform X12

    UniProtKB/TrEMBL
    A0A1S6GWF9
    Conserved Domains (1) summary
    pfam05644
    Location:1317
    Miff; Mitochondrial and peroxisomal fission factor Mff
  20. XM_036154187.1XP_036010080.1  mitochondrial fission factor isoform X8

    UniProtKB/TrEMBL
    A0A1S6GWF9
    Conserved Domains (1) summary
    pfam05644
    Location:1327
    Miff; Mitochondrial and peroxisomal fission factor Mff
  21. XM_036154194.1XP_036010087.1  mitochondrial fission factor isoform X13

    UniProtKB/TrEMBL
    A0A1S6GWF9, E0CYB9
    Related
    ENSMUSP00000124334.2, ENSMUST00000162003.8
    Conserved Domains (1) summary
    pfam05644
    Location:1316
    Miff; Mitochondrial and peroxisomal fission factor Mff
  22. XM_036154199.1XP_036010092.1  mitochondrial fission factor isoform X16

    UniProtKB/TrEMBL
    A0A1S6GWF9
    Conserved Domains (1) summary
    pfam05644
    Location:1296
    Miff; Mitochondrial and peroxisomal fission factor Mff