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Tmem14a transmembrane protein 14A [ Mus musculus (house mouse) ]

Gene ID: 75712, updated on 5-Mar-2024

Summary

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Official Symbol
Tmem14aprovided by MGI
Official Full Name
transmembrane protein 14Aprovided by MGI
Primary source
MGI:MGI:1922962
See related
Ensembl:ENSMUSG00000025933 AllianceGenome:MGI:1922962
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PTD011; 5730496E24Rik
Summary
Predicted to be involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. Predicted to be located in endoplasmic reticulum; membrane; and mitochondrion. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane and mitochondrial membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. Orthologous to human TMEM14A (transmembrane protein 14A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 12.5), frontal lobe adult (RPKM 9.9) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 A4; 1 6.5 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (21236609..21300391)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (21166436..21230167)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51618 Neighboring gene STARR-seq mESC enhancer starr_00396 Neighboring gene STARR-seq mESC enhancer starr_00397 Neighboring gene EF-hand domain (C-terminal) containing 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:20985434-20985617 Neighboring gene translocating chain-associating membrane protein 2 Neighboring gene STARR-positive B cell enhancer mm9_chr1:21030259-21030560 Neighboring gene STARR-seq mESC enhancer starr_00399 Neighboring gene STARR-seq mESC enhancer starr_00401 Neighboring gene STARR-seq mESC enhancer starr_00402 Neighboring gene predicted gene, 32947 Neighboring gene predicted gene 28836 Neighboring gene STARR-seq mESC enhancer starr_00405 Neighboring gene STARR-seq mESC enhancer starr_00406 Neighboring gene glutathione S-transferase, alpha 3 Neighboring gene predicted pseudogene 7094

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of heme biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 14A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290679.1 → NP_001277608.1  transmembrane protein 14A isoform 1

    See identical proteins and their annotated locations for NP_001277608.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC163025, AK017734, BC060034
    Consensus CDS
    CCDS69867.1
    UniProtKB/TrEMBL
    D3YV08
    Related
    ENSMUSP00000027064.8, ENSMUST00000027064.8
    Conserved Domains (1) summary
    pfam03647
    Location:4 → 86
    Tmemb_14; Transmembrane proteins 14C

  2. NM_029398.3 → NP_083674.2  transmembrane protein 14A isoform 2

    See identical proteins and their annotated locations for NP_083674.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded protein (isoform 2) has a shorter and distinct C-teriminus, compared to isoform 1.
    Source sequence(s)
    AC163025, BC060034
    Consensus CDS
    CCDS35523.1
    UniProtKB/Swiss-Prot
    P56983, Q8JZZ3
    Related
    ENSMUSP00000027065.6, ENSMUST00000027065.12
    Conserved Domains (1) summary
    pfam03647
    Location:4 → 87
    Tmemb_14; Transmembrane proteins 14C

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    21236609..21300391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495579.3 → XP_006495642.1  transmembrane protein 14A isoform X1

    Conserved Domains (1) summary
    pfam03647
    Location:11 → 93
    Tmemb_14; Transmembrane proteins 14C

  2. XM_006495581.3 → XP_006495644.1  transmembrane protein 14A isoform X2

    Conserved Domains (1) summary
    pfam03647
    Location:11 → 94
    Tmemb_14; Transmembrane proteins 14C
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56983.2 GenPept UniProtKB/Swiss-Prot:P56983

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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