U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Shld2 shieldin complex subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 75698, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Shld2provided by MGI
Official Full Name
shieldin complex subunit 2provided by MGI
Primary source
MGI:MGI:1922948
See related
Ensembl:ENSMUSG00000041471 AllianceGenome:MGI:1922948
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam35a; 3110001K24Rik
Summary
Predicted to be involved in negative regulation of double-strand break repair via homologous recombination; positive regulation of double-strand break repair via nonhomologous end joining; and positive regulation of isotype switching. Predicted to act upstream of or within DNA repair. Predicted to be located in chromosome. Predicted to be active in nucleus and site of double-strand break. Orthologous to human SHLD2 (shieldin complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E18 (RPKM 3.2), liver adult (RPKM 2.5) and 26 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Shld2 in Genome Data Viewer
Location:
14 B; 14 20.8 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (33958905..34032528, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (34236948..34310651, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36364 Neighboring gene VISTA enhancer mm340 Neighboring gene G protein regulated inducer of neurite outgrowth 2 Neighboring gene synaptotagmin XV Neighboring gene STARR-seq mESC enhancer starr_36366 Neighboring gene zinc finger, DHHC domain containing 17 pseudogene Neighboring gene STARR-seq mESC enhancer starr_36368 Neighboring gene STARR-seq mESC enhancer starr_36370 Neighboring gene STARR-seq mESC enhancer starr_36372 Neighboring gene STARR-seq mESC enhancer starr_36373 Neighboring gene glutamate dehydrogenase 1 Neighboring gene B-cell CLL/lymphoma 7C pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. 53BP1-shieldin-dependent DSB processing in BRCA1-deficient cells requires CST-Polα-primase fill-in synthesis. Mirman Z, et al. Nat Cell Biol, 2022 Jan. PMID 35027730, Free PMC Article
  2. A molecular profile of a hematopoietic stem cell niche. Hackney JA, et al. Proc Natl Acad Sci U S A, 2002 Oct 1. PMID 12226475, Free PMC Article
  3. DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity. Gupta R, et al. Cell, 2018 May 3. PMID 29656893, Free PMC Article
  4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of double-strand break repair via nonhomologous end joining ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of double-strand break repair via nonhomologous end joining NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of isotype switching ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in somatic diversification of immunoglobulins involved in immune response NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in telomere maintenance in response to DNA damage NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
part_of chromatin NAS
Non-traceable Author Statement
more info
 PubMed 
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
  
located_in site of double-strand break NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
shieldin complex subunit 2
Names
RINN1-REV7-interacting novel NHEJ regulator 2
family with sequence similarity 35, member A
protein FAM35A

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360074.1 → NP_001347003.1  shieldin complex subunit 2

    Status: VALIDATED

    Source sequence(s)
    AC154738, AK149442, BE630700, BE648821, BE848901, BF467362, BQ829235, BU756157
    Consensus CDS
    CCDS36874.1
    UniProtKB/Swiss-Prot
    E9Q8K3, Q3UEN2
    UniProtKB/TrEMBL
    B7ZMV3
    Conserved Domains (1) summary
    pfam15793
    Location:695 → 866
    FAM35_C; Protein family FAM35, C-terminal

  2. NM_029389.3 → NP_083665.2  shieldin complex subunit 2

    See identical proteins and their annotated locations for NP_083665.2

    Status: VALIDATED

    Source sequence(s)
    AI451789, AK149442, BF467362, BU756157, CD547520
    Consensus CDS
    CCDS36874.1
    UniProtKB/Swiss-Prot
    E9Q8K3, Q3UEN2
    UniProtKB/TrEMBL
    B7ZMV3
    Related
    ENSMUSP00000107548.2, ENSMUST00000111917.3
    Conserved Domains (1) summary
    pfam15793
    Location:695 → 866
    FAM35_C; Protein family FAM35, C-terminal

RNA

  1. NR_153399.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154738, AC160930, AK149442, BE630700, BE848901, BF467362, BQ829235, BU756157

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    33958905..34032528 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519652.5 → XP_006519715.1  shieldin complex subunit 2 isoform X4

    See identical proteins and their annotated locations for XP_006519715.1

    Conserved Domains (1) summary
    pfam15793
    Location:143 → 314
    FAM35_C; Protein family FAM35, C-terminal

  2. XM_017316219.3 → XP_017171708.1  shieldin complex subunit 2 isoform X4

    Conserved Domains (1) summary
    pfam15793
    Location:143 → 314
    FAM35_C; Protein family FAM35, C-terminal

  3. XM_011245218.4 → XP_011243520.1  shieldin complex subunit 2 isoform X2

    UniProtKB/TrEMBL
    B7ZMV3
    Conserved Domains (1) summary
    pfam15793
    Location:659 → 830
    FAM35_C; Protein family FAM35, C-terminal

  4. XM_006519650.5 → XP_006519713.1  shieldin complex subunit 2 isoform X3

    Conserved Domains (1) summary
    pfam15793
    Location:178 → 349
    FAM35_C; Protein family FAM35, C-terminal

  5. XM_006519651.4 → XP_006519714.1  shieldin complex subunit 2 isoform X4

    See identical proteins and their annotated locations for XP_006519714.1

    Conserved Domains (1) summary
    pfam15793
    Location:143 → 314
    FAM35_C; Protein family FAM35, C-terminal

  6. XM_011245216.4 → XP_011243518.1  shieldin complex subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_011243518.1

    UniProtKB/Swiss-Prot
    E9Q8K3, Q3UEN2
    UniProtKB/TrEMBL
    B7ZMV3
    Conserved Domains (1) summary
    pfam15793
    Location:695 → 866
    FAM35_C; Protein family FAM35, C-terminal

  7. XM_006519646.5 → XP_006519709.1  shieldin complex subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_006519709.1

    UniProtKB/Swiss-Prot
    E9Q8K3, Q3UEN2
    UniProtKB/TrEMBL
    B7ZMV3
    Conserved Domains (1) summary
    pfam15793
    Location:695 → 866
    FAM35_C; Protein family FAM35, C-terminal

  8. XM_006519648.5 → XP_006519711.1  shieldin complex subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_006519711.1

    UniProtKB/Swiss-Prot
    E9Q8K3, Q3UEN2
    UniProtKB/TrEMBL
    B7ZMV3
    Conserved Domains (1) summary
    pfam15793
    Location:695 → 866
    FAM35_C; Protein family FAM35, C-terminal

  9. XM_006519645.5 → XP_006519708.1  shieldin complex subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_006519708.1

    UniProtKB/Swiss-Prot
    E9Q8K3, Q3UEN2
    UniProtKB/TrEMBL
    B7ZMV3
    Conserved Domains (1) summary
    pfam15793
    Location:695 → 866
    FAM35_C; Protein family FAM35, C-terminal

RNA

  1. XR_001781163.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UEN2.2 GenPept UniProtKB/Swiss-Prot:Q3UEN2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous