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Nr2c2ap nuclear receptor 2C2-associated protein [ Mus musculus (house mouse) ]

Gene ID: 75692, updated on 5-Mar-2024

Summary

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Official Symbol
Nr2c2approvided by MGI
Official Full Name
nuclear receptor 2C2-associated proteinprovided by MGI
Primary source
MGI:MGI:1922942
See related
Ensembl:ENSMUSG00000071078 AllianceGenome:MGI:1922942
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310073E15Rik
Summary
Predicted to be located in nucleoplasm. Orthologous to human NR2C2AP (nuclear receptor 2C2 associated protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 15.0), thymus adult (RPKM 13.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 B3.3; 8 34.15 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70583977..70586402)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70131327..70133752)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene neurocan Neighboring gene microRNA 7066 Neighboring gene predicted gene, 25906 Neighboring gene regulatory factor X-associated ankyrin-containing protein Neighboring gene STARR-positive B cell enhancer ABC_E1102 Neighboring gene BLOC-1 related complex subunit 8 Neighboring gene myocyte enhancer factor 2B like Neighboring gene STARR-seq mESC enhancer starr_21765 Neighboring gene STARR-positive B cell enhancer ABC_E3776 Neighboring gene myocyte enhancer factor 2B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC103332

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nuclear receptor 2C2-associated protein
Names
TR4 orphan receptor-associated 16 kDa protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025586.2 → NP_001020757.1  nuclear receptor 2C2-associated protein isoform 1

    See identical proteins and their annotated locations for NP_001020757.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
    Source sequence(s)
    AA111465, AK160346, BY100716
    Consensus CDS
    CCDS40366.1
    UniProtKB/Swiss-Prot
    Q3TV70
    Related
    ENSMUSP00000092907.6, ENSMUST00000095273.7
    Conserved Domains (1) summary
    cl02148
    Location:12 → 91
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination

  2. NM_001025587.2 → NP_001020758.1  nuclear receptor 2C2-associated protein isoform 2

    See identical proteins and their annotated locations for NP_001020758.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This encodes a protein (isoform 2) that is shorter than isoform 1.
    Source sequence(s)
    AA111465, AK010864, AK160346, BY100716
    UniProtKB/TrEMBL
    Q569V8
    Conserved Domains (1) summary
    cl02148
    Location:12 → 102
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination

RNA

  1. NR_104434.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AA111465, AK010864, BY100716
    Related
    ENSMUST00000211898.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    70583977..70586402
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509777.2 → XP_006509840.1  nuclear receptor 2C2-associated protein isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001025588.1: Suppressed sequence

    Description
    NM_001025588.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TV70.1 GenPept UniProtKB/Swiss-Prot:Q3TV70

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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