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Ripor1 RHO family interacting cell polarization regulator 1 [ Mus musculus (house mouse) ]

Gene ID: 75687, updated on 5-Mar-2024

Summary

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Official Symbol
Ripor1provided by MGI
Official Full Name
RHO family interacting cell polarization regulator 1provided by MGI
Primary source
MGI:MGI:1922937
See related
Ensembl:ENSMUSG00000038604 AllianceGenome:MGI:1922937
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam65a; 2310066E14Rik
Summary
Predicted to enable 14-3-3 protein binding activity. Predicted to be involved in several processes, including establishment of Golgi localization; negative regulation of Rho guanyl-nucleotide exchange factor activity; and negative regulation of Rho protein signal transduction. Located in cytoplasm. Is expressed in several structures, including adrenal gland; genitourinary system; hemolymphoid system; liver; and lung. Orthologous to human RIPOR1 (RHO family interacting cell polarization regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 26.2), lung adult (RPKM 19.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ripor1 in Genome Data Viewer
Location:
8 D3; 8 53.04 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106320588..106348851)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105594087..105622219)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:108090885-108090994 Neighboring gene predicted gene, 38250 Neighboring gene agouti related neuropeptide Neighboring gene predicted gene 45855 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:108146466-108146676 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:108147057-108147307 Neighboring gene microRNA 1966 Neighboring gene predicted gene 5914 Neighboring gene CCCTC-binding factor Neighboring gene myosin light polypeptide 6-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transcriptional regulation of agouti-related protein (Agrp) in transgenic mice. Kaelin CB, et al. Endocrinology, 2004 Dec. PMID 15345681
  2. Expression and subcellular distribution of novel glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2, and 2310066E14Rik. Patrakka J, et al. J Am Soc Nephrol, 2007 Mar. PMID 17251388
  3. Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator. Keegan CE, et al. Hum Mol Genet, 2005 Jan 1. PMID 15537664
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC100216

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to chemokine ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of Golgi localization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of Rho guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
involved_in response to wounding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rho family-interacting cell polarization regulator 1
Names
family with sequence similarity 65, member A
protein FAM65A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081241.2 → NP_001074710.2  rho family-interacting cell polarization regulator 1

    See identical proteins and their annotated locations for NP_001074710.2

    Status: VALIDATED

    Source sequence(s)
    AK122573, BB852730, BC079880
    Consensus CDS
    CCDS52660.1
    UniProtKB/Swiss-Prot
    G5E8A2, Q68FE6, Q80T73, Q8K0T1, Q9D6R4
    Related
    ENSMUSP00000039966.9, ENSMUST00000043531.10
    Conserved Domains (4) summary
    pfam05109
    Location:444 → 749
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00044
    Location:1097 → 1127
    HEAT; HEAT repeat [structural motif]
    pfam13646
    Location:1125 → 1189
    HEAT_2; HEAT repeats
    pfam15903
    Location:17 → 365
    PL48; Filopodia upregulated, FAM65

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    106320588..106348851
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248531.4 → XP_011246833.2  rho family-interacting cell polarization regulator 1 isoform X1

    Conserved Domains (4) summary
    pfam05109
    Location:524 → 829
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00044
    Location:1177 → 1207
    HEAT; HEAT repeat [structural motif]
    pfam13646
    Location:1205 → 1269
    HEAT_2; HEAT repeats
    pfam15903
    Location:97 → 445
    PL48; Filopodia upregulated, FAM65

  2. XM_011248532.4 → XP_011246834.2  rho family-interacting cell polarization regulator 1 isoform X2

    Conserved Domains (4) summary
    pfam05109
    Location:524 → 829
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00044
    Location:1176 → 1206
    HEAT; HEAT repeat [structural motif]
    pfam13646
    Location:1204 → 1268
    HEAT_2; HEAT repeats
    pfam15903
    Location:97 → 445
    PL48; Filopodia upregulated, FAM65

  3. XM_036154352.1 → XP_036010245.1  rho family-interacting cell polarization regulator 1 isoform X6

    Conserved Domains (2) summary
    pfam05109
    Location:561 → 829
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam15903
    Location:97 → 445
    PL48; Filopodia upregulated, FAM65

  4. XM_036154351.1 → XP_036010244.1  rho family-interacting cell polarization regulator 1 isoform X4

    UniProtKB/Swiss-Prot
    G5E8A2, Q68FE6, Q80T73, Q8K0T1, Q9D6R4
    Conserved Domains (4) summary
    pfam05109
    Location:444 → 749
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00044
    Location:1097 → 1127
    HEAT; HEAT repeat [structural motif]
    pfam13646
    Location:1125 → 1189
    HEAT_2; HEAT repeats
    pfam15903
    Location:17 → 365
    PL48; Filopodia upregulated, FAM65

  5. XM_006531461.5 → XP_006531524.1  rho family-interacting cell polarization regulator 1 isoform X3

    Conserved Domains (4) summary
    pfam05109
    Location:495 → 763
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00044
    Location:1111 → 1141
    HEAT; HEAT repeat [structural motif]
    pfam15903
    Location:31 → 379
    PL48; Filopodia upregulated, FAM65
    pfam13646
    Location:1139 → 1203
    HEAT_2; HEAT repeats

  6. XM_006531463.2 → XP_006531526.1  rho family-interacting cell polarization regulator 1 isoform X5

    Conserved Domains (4) summary
    pfam05109
    Location:447 → 715
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00044
    Location:1063 → 1093
    HEAT; HEAT repeat [structural motif]
    pfam15903
    Location:2 → 331
    PL48; Filopodia upregulated, FAM65
    pfam13646
    Location:1091 → 1155
    HEAT_2; HEAT repeats

  7. XM_030243830.1 → XP_030099690.1  rho family-interacting cell polarization regulator 1 isoform X7

    Conserved Domains (4) summary
    pfam05109
    Location:286 → 591
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00044
    Location:939 → 969
    HEAT; HEAT repeat [structural motif]
    pfam15903
    Location:1 → 207
    PL48; Filopodia upregulated, FAM65
    pfam13646
    Location:967 → 1031
    HEAT_2; HEAT repeats
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68FE6.2 GenPept UniProtKB/Swiss-Prot:Q68FE6

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