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Ippk inositol 1,3,4,5,6-pentakisphosphate 2-kinase [ Mus musculus (house mouse) ]

Gene ID: 75678, updated on 11-Apr-2024

Summary

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Official Symbol
Ippkprovided by MGI
Official Full Name
inositol 1,3,4,5,6-pentakisphosphate 2-kinaseprovided by MGI
Primary source
MGI:MGI:1922928
See related
Ensembl:ENSMUSG00000021385 AllianceGenome:MGI:1922928
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
InsP6; 1810043M15Rik
Summary
Predicted to enable inositol pentakisphosphate 2-kinase activity and molecular adaptor activity. Predicted to be involved in inositol phosphate biosynthetic process; inositol phosphorylation; and positive regulation of transcription of nucleolar large rRNA by RNA polymerase I. Predicted to act upstream of or within phosphorylation. Predicted to be located in nucleolus. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Orthologous to human IPPK (inositol-pentakisphosphate 2-kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 15.4), testis adult (RPKM 4.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 A5; 13 25.25 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (49574673..49618050)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (49421198..49464574)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E030007A22 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:49363145-49363298 Neighboring gene FYVE, RhoGEF and PH domain containing 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:49402581-49402764 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:49402849-49403036 Neighboring gene STARR-positive B cell enhancer ABC_E4067 Neighboring gene BICD cargo adaptor 2 Neighboring gene STARR-seq mESC enhancer starr_34478 Neighboring gene centromere protein P Neighboring gene testis derived transcript 3, pseudogene Neighboring gene extracellular matrix protein 2, female organ and adipocyte specific

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The crystal structure of mammalian inositol 1,3,4,5,6-pentakisphosphate 2-kinase reveals a new zinc-binding site and key features for protein function. Franco-Echevarría E, et al. J Biol Chem, 2017 Jun 23. PMID 28450399, Free PMC Article
  2. Crystallization and Preliminary X-Ray Diffraction Analysis of a Mammal Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase. Franco-Echevarría E, et al. Protein J, 2017 Aug. PMID 28429156
  3. Disruption of the mouse inositol 1,3,4,5,6-pentakisphosphate 2-kinase gene, associated lethality, and tissue distribution of 2-kinase expression. Verbsky J, et al. Proc Natl Acad Sci U S A, 2005 Jun 14. PMID 15939868, Free PMC Article
  4. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crystallization and preliminary x-ray diffraction analysis of a mouse inositol 1,3,4,5,6-pentakisphosphate 2-kinase has been reported.
    Title: Crystallization and Preliminary X-Ray Diffraction Analysis of a Mammal Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase.
  2. findings have uncovered distinct features of a mammalian IP5 2-K and set the stage for investigations into protein-protein or protein-RNA interactions important for IP5 2-K function and activity
    Title: The crystal structure of mammalian inositol 1,3,4,5,6-pentakisphosphate 2-kinase reveals a new zinc-binding site and key features for protein function.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables inositol pentakisphosphate 2-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol pentakisphosphate 2-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in inositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
inositol-pentakisphosphate 2-kinase
Names
ins(1,3,4,5,6)P5 2-kinase
insP5 2-kinase
NP_001263328.1
NP_951011.1
XP_017171117.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276399.2 → NP_001263328.1  inositol-pentakisphosphate 2-kinase isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' exon and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is longer and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AC123954
    Consensus CDS
    CCDS88452.1
    UniProtKB/TrEMBL
    A0A217FL54
    Related
    ENSMUSP00000021817.10, ENSMUST00000021817.10
    Conserved Domains (1) summary
    pfam06090
    Location:80 → 504
    Ins_P5_2-kin; Inositol-pentakisphosphate 2-kinase

  2. NM_199056.4 → NP_951011.1  inositol-pentakisphosphate 2-kinase isoform a

    See identical proteins and their annotated locations for NP_951011.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the shorter isoform (a).
    Source sequence(s)
    AC123954
    Consensus CDS
    CCDS26500.1
    UniProtKB/Swiss-Prot
    Q3V3Z0, Q6P1C1
    UniProtKB/TrEMBL
    Q05CK0
    Related
    ENSMUSP00000152331.2, ENSMUST00000220447.2
    Conserved Domains (1) summary
    pfam06090
    Location:13 → 455
    Ins_P5_2-kin; Inositol-pentakisphosphate 2-kinase

RNA

  1. NR_075085.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon near the 5' end, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC123954, AK160092, AV306360, BB619387, CD353694, DV647168
    Related
    ENSMUST00000220856.2

  2. NR_165080.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC123954

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    49574673..49618050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315628.3 → XP_017171117.1  inositol-pentakisphosphate 2-kinase isoform X1

    Conserved Domains (1) summary
    pfam06090
    Location:13 → 201
    Ins_P5_2-kin; Inositol-pentakisphosphate 2-kinase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P1C1.1 GenPept UniProtKB/Swiss-Prot:Q6P1C1

Gene LinkOut

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