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ZNF17 zinc finger protein 17 [ Homo sapiens (human) ]

Gene ID: 7565, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF17provided by HGNC
Official Full Name
zinc finger protein 17provided by HGNC
Primary source
HGNC:HGNC:12958
See related
Ensembl:ENSG00000186272 MIM:619254; AllianceGenome:HGNC:12958
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HPF3; KOX10
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 2.0), ovary (RPKM 1.8) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
19q13.43
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57411161..57421934)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (60508194..60518967)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (57922529..57933302)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15136 Neighboring gene trafficking protein particle complex subunit 2B Neighboring gene zinc finger protein 547 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15137 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15138 Neighboring gene zinc finger protein 548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:57915187-57915686 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15139 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15141 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:57923026-57923228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15142 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15143 Neighboring gene zinc finger protein 749 Neighboring gene vomeronasal 1 receptor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human proviral mRNAs down regulated in choriocarcinoma encode a zinc finger protein related to Krüppel. Kato N, et al. Mol Cell Biol, 1990 Aug. PMID 2115127, Free PMC Article
  2. Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. Huebner K, et al. Am J Hum Genet, 1991 Apr. PMID 2014798, Free PMC Article
  3. Multiple genes encoding zinc finger domains are expressed in human T cells. Thiesen HJ. New Biol, 1990 Apr. PMID 2288909
  4. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. Nagase T, et al. DNA Res, 2001 Dec 31. PMID 11853319
  5. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. Camargo LM, et al. Mol Psychiatry, 2007 Jan. PMID 17043677

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ40864, FLJ46058, FLJ46615, KIAA1947

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 17
Names
zinc finger protein 17 (HPF3, KOX 10)
zinc finger protein HPF3
zinc finger protein KOX10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330617.2 → NP_001317546.1  zinc finger protein 17 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC003002, AK127948, CK906092
    Consensus CDS
    CCDS82405.1
    UniProtKB/Swiss-Prot
    P17021
    Related
    ENSP00000302455.7, ENST00000307658.12
    Conserved Domains (4) summary
    COG5048
    Location:246 → 658
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:222 → 242
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:12 → 49
    KRAB; KRAB box
    pfam13465
    Location:487 → 511
    zf-H2C2_2; Zinc-finger double domain

  2. NM_006959.3 → NP_008890.2  zinc finger protein 17 isoform 2

    See identical proteins and their annotated locations for NP_008890.2

    Status: VALIDATED

    Source sequence(s)
    AC003002, DA476988, DA746547
    Consensus CDS
    CCDS42636.1
    UniProtKB/Swiss-Prot
    B3KXU2, B3KY20, P17021, Q8N7M1, Q8N893, Q8TF54
    Related
    ENSP00000471905.1, ENST00000601808.1
    Conserved Domains (4) summary
    COG5048
    Location:244 → 656
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:220 → 240
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:10 → 47
    KRAB; KRAB box
    pfam13465
    Location:485 → 509
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    57411161..57421934
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439311.1 → XP_047295267.1  zinc finger protein 17 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    60508194..60518967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321947.1 → XP_054177922.1  zinc finger protein 17 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17021.3 GenPept UniProtKB/Swiss-Prot:P17021

Gene LinkOut

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