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Ssmem1 serine-rich single-pass membrane protein 1 [ Mus musculus (house mouse) ]

Gene ID: 75647, updated on 5-Mar-2024

Summary

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Official Symbol
Ssmem1provided by MGI
Official Full Name
serine-rich single-pass membrane protein 1provided by MGI
Primary source
MGI:MGI:1922897
See related
Ensembl:ENSMUSG00000029784 AllianceGenome:MGI:1922897
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700016K02Rik; 1700025E21Rik
Summary
Orthologous to human SSMEM1 (serine rich single-pass membrane protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 30.5) See more
Orthologs
human all
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Genomic context

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See Ssmem1 in Genome Data Viewer
Location:
6 A3.3; 6 12.52 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (30509790..30520253)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (30509791..30520254)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700012C14 gene Neighboring gene transmembrane protein 209 Neighboring gene STARR-seq mESC enhancer starr_15468 Neighboring gene predicted gene, 53278 Neighboring gene carboxypeptidase A2, pancreatic Neighboring gene carboxypeptidase A4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Knockout of serine-rich single-pass membrane protein 1 (Ssmem1) causes globozoospermia and sterility in male mice†. Nozawa K, et al. Biol Reprod, 2020 Aug 4. PMID 32301969, Free PMC Article
  2. Identification and integrative analysis of 28 novel genes specifically expressed and developmentally regulated in murine spermatogenic cells. Hong S, et al. J Biol Chem, 2005 Mar 4. PMID 15613475
  3. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockout of serine-rich single-pass membrane protein 1 (Ssmem1) causes globozoospermia and sterility in male micedagger.
    Title: Knockout of serine-rich single-pass membrane protein 1 (Ssmem1) causes globozoospermia and sterility in male mice†.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
serine-rich single-pass membrane protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027073.1 → NP_081349.1  serine-rich single-pass membrane protein 1 isoform a

    See identical proteins and their annotated locations for NP_081349.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (a).
    Source sequence(s)
    AC155848, AK006038
    Consensus CDS
    CCDS57417.1
    UniProtKB/TrEMBL
    Q9DAA0
    Related
    ENSMUSP00000031797.5, ENSMUST00000031797.11
    Conserved Domains (1) summary
    pfam15468
    Location:1 → 195
    DUF4636; Domain of unknown function (DUF4636)

  2. NM_029373.4 → NP_083649.1  serine-rich single-pass membrane protein 1 isoform b

    See identical proteins and their annotated locations for NP_083649.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate exon in the 5' UTR and 5' coding region, compared to variant 1. It encodes isoform b which is longer and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AC155848, AK006038, AK006332, BU938696
    Consensus CDS
    CCDS19973.1
    UniProtKB/TrEMBL
    Q9D9Y8
    Related
    ENSMUSP00000031798.8, ENSMUST00000031798.14
    Conserved Domains (1) summary
    pfam15468
    Location:1 → 243
    DUF4636; Domain of unknown function (DUF4636)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    30509790..30520253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505195.4 → XP_006505258.1  serine-rich single-pass membrane protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006505258.1

    UniProtKB/TrEMBL
    Q78FQ7
    Conserved Domains (1) summary
    pfam15468
    Location:1 → 182
    DUF4636; Domain of unknown function (DUF4636)

  2. XM_006505194.4 → XP_006505257.1  serine-rich single-pass membrane protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006505257.1

    UniProtKB/TrEMBL
    Q78FQ7
    Conserved Domains (1) summary
    pfam15468
    Location:1 → 182
    DUF4636; Domain of unknown function (DUF4636)

  3. XM_017321817.1 → XP_017177306.1  serine-rich single-pass membrane protein 1 isoform X1

    UniProtKB/TrEMBL
    Q78FQ7
    Conserved Domains (1) summary
    pfam15468
    Location:1 → 182
    DUF4636; Domain of unknown function (DUF4636)
Nucleotide Protein Strain
Heading Accession and Version

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