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Rai14 retinoic acid induced 14 [ Mus musculus (house mouse) ]

Gene ID: 75646, updated on 11-Apr-2024

Summary

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Official Symbol
Rai14provided by MGI
Official Full Name
retinoic acid induced 14provided by MGI
Primary source
MGI:MGI:1922896
See related
Ensembl:ENSMUSG00000022246 AllianceGenome:MGI:1922896
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Norpeg; mKIAA1334; Ankycorbin; 1700008J19Rik; 1700020L11Rik
Summary
Predicted to enable actin binding activity. Predicted to act upstream of or within cell differentiation and spermatogenesis. Located in mitochondrion. Is expressed in several structures, including brain; genitourinary system; jaw; neural ectoderm; and retina. Orthologous to human RAI14 (retinoic acid induced 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 20.4), CNS E11.5 (RPKM 13.8) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 A1; 15 5.35 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (10569057..10719353, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (10568971..10719267, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37954 Neighboring gene tetratricopeptide repeat domain 23-like Neighboring gene RAD1 checkpoint DNA exonuclease Neighboring gene STARR-seq mESC enhancer starr_37955 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene 10389 Neighboring gene RIKEN cDNA 4930556M19 gene Neighboring gene predicted gene, 52214 Neighboring gene STARR-seq mESC enhancer starr_37980 Neighboring gene STARR-seq mESC enhancer starr_37983 Neighboring gene predicted gene, 19276 Neighboring gene predicted gene, 29742

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Retinoic acid-induced protein 14 controls dendritic spine dynamics associated with depressive-like behaviors. Kim SJ, et al. Elife, 2022 Apr 25. PMID 35467532, Free PMC Article
  2. Retinoic Acid Induced Protein 14 (Rai14) is dispensable for mouse spermatogenesis. Wu Y, et al. PeerJ, 2021. PMID 33643708, Free PMC Article
  3. Immunofluorescence analysis of the expression of Norpeg (Rai14) in retinal Müller and ganglion cells. Kutty RK, et al. Neurosci Lett, 2006 Sep 1. PMID 16806700
  4. Ankycorbin: a novel actin cytoskeleton-associated protein. Peng YF, et al. Genes Cells, 2000 Dec. PMID 11168586
  5. Molecular characterization and developmental expression of NORPEG, a novel gene induced by retinoic acid. Kutty RK, et al. J Biol Chem, 2001 Jan 26. PMID 11042181

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ankycorbin
Names
NORPEG-like protein
ankyrin repeat and coiled-coil structure-containing protein
novel retinal pigment epithelial cell protein
p125
retinoic acid-induced protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166408.2 → NP_001159880.1  ankycorbin isoform 1

    See identical proteins and their annotated locations for NP_001159880.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC158921
    Consensus CDS
    CCDS37043.1
    UniProtKB/Swiss-Prot
    Q3URT3, Q6ZPT6, Q9EP71
    Related
    ENSMUSP00000126325.2, ENSMUST00000169385.3
    Conserved Domains (4) summary
    PHA03095
    Location:12 → 224
    PHA03095; ankyrin-like protein; Provisional
    COG1196
    Location:431 → 898
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    sd00045
    Location:118 → 149
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:90 → 182
    Ank_2; Ankyrin repeats (3 copies)

  2. NM_001356534.2 → NP_001343463.1  ankycorbin isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC158921
    Consensus CDS
    CCDS88734.1
    UniProtKB/TrEMBL
    A0A2I3BPY7
    Related
    ENSMUSP00000153969.2, ENSMUST00000227506.2
    Conserved Domains (4) summary
    PHA03095
    Location:12 → 224
    PHA03095; ankyrin-like protein; Provisional
    COG1196
    Location:402 → 869
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    sd00045
    Location:118 → 149
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:90 → 182
    Ank_2; Ankyrin repeats (3 copies)

  3. NM_030690.4 → NP_109615.1  ankycorbin isoform 1

    See identical proteins and their annotated locations for NP_109615.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC158921
    Consensus CDS
    CCDS37043.1
    UniProtKB/Swiss-Prot
    Q3URT3, Q6ZPT6, Q9EP71
    Related
    ENSMUSP00000087815.4, ENSMUST00000090339.11
    Conserved Domains (4) summary
    PHA03095
    Location:12 → 224
    PHA03095; ankyrin-like protein; Provisional
    COG1196
    Location:431 → 898
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    sd00045
    Location:118 → 149
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:90 → 182
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    10569057..10719353 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520187.2 → XP_006520250.1  ankycorbin isoform X1

    See identical proteins and their annotated locations for XP_006520250.1

    UniProtKB/Swiss-Prot
    Q3URT3, Q6ZPT6, Q9EP71
    Conserved Domains (4) summary
    PHA03095
    Location:12 → 224
    PHA03095; ankyrin-like protein; Provisional
    COG1196
    Location:431 → 898
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    sd00045
    Location:118 → 149
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:90 → 182
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_030248808.1 → XP_030104668.1  ankycorbin isoform X2

    UniProtKB/TrEMBL
    A0A2I3BPY7
    Conserved Domains (4) summary
    PHA03095
    Location:12 → 224
    PHA03095; ankyrin-like protein; Provisional
    COG1196
    Location:402 → 869
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    sd00045
    Location:118 → 149
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:90 → 182
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_006520188.5 → XP_006520251.1  ankycorbin isoform X1

    See identical proteins and their annotated locations for XP_006520251.1

    UniProtKB/Swiss-Prot
    Q3URT3, Q6ZPT6, Q9EP71
    Conserved Domains (4) summary
    PHA03095
    Location:12 → 224
    PHA03095; ankyrin-like protein; Provisional
    COG1196
    Location:431 → 898
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    sd00045
    Location:118 → 149
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:90 → 182
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_006520190.4 → XP_006520253.1  ankycorbin isoform X2

    UniProtKB/TrEMBL
    A0A2I3BPY7
    Conserved Domains (4) summary
    PHA03095
    Location:12 → 224
    PHA03095; ankyrin-like protein; Provisional
    COG1196
    Location:402 → 869
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    sd00045
    Location:118 → 149
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:90 → 182
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_006520192.4 → XP_006520255.1  ankycorbin isoform X3

    Conserved Domains (4) summary
    PHA03095
    Location:12 → 224
    PHA03095; ankyrin-like protein; Provisional
    COG1196
    Location:373 → 840
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    sd00045
    Location:118 → 149
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:90 → 182
    Ank_2; Ankyrin repeats (3 copies)

  6. XM_017316775.2 → XP_017172264.1  ankycorbin isoform X1

    UniProtKB/Swiss-Prot
    Q3URT3, Q6ZPT6, Q9EP71
    Conserved Domains (4) summary
    PHA03095
    Location:12 → 224
    PHA03095; ankyrin-like protein; Provisional
    COG1196
    Location:431 → 898
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    sd00045
    Location:118 → 149
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:90 → 182
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EP71.1 GenPept UniProtKB/Swiss-Prot:Q9EP71

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