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ZNF16 zinc finger protein 16 [ Homo sapiens (human) ]

Gene ID: 7564, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF16provided by HGNC
Official Full Name
zinc finger protein 16provided by HGNC
Primary source
HGNC:HGNC:12947
See related
Ensembl:ENSG00000170631 MIM:601262; AllianceGenome:HGNC:12947
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HZF1; KOX9
Summary
The protein encoded by this gene contains multiple tandem zinc finger motifs. The encoded protein is involved in the differentiation of erythroid and megakaryocytic cells. This gene is located in a cluster of related genes on chromosome 8 encoding zinc finger proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
Expression
Ubiquitous expression in ovary (RPKM 5.1), testis (RPKM 4.3) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF16 in Genome Data Viewer
Location:
8q24.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (144930358..144950880, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (146104378..146126046, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (146155744..146176266, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:146064238-146064791 Neighboring gene zinc finger protein 7 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:146076290-146076441 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:146077648-146078496 Neighboring gene COMM domain containing 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19714 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28107 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28108 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28109 Neighboring gene zinc finger protein 250 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:146126184-146126788 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:146126789-146127391 Neighboring gene uncharacterized LOC124902042 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146127392-146127995 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19717 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28110 Neighboring gene zinc finger protein 252, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:146228590-146229166 Neighboring gene ZNF252P antisense RNA 1 Neighboring gene transmembrane p24 trafficking protein 10 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Exome sequencing identifies new somatic alterations and mutation patterns of tongue squamous cell carcinoma in a Chinese population. Zhang H, et al. J Pathol, 2020 Aug. PMID 32432340
  2. Identification of the trans-activation domain and the nuclear location signals of human zinc finger protein HZF1 (ZNF16). Deng MJ, et al. Mol Biotechnol, 2010 Feb. PMID 19763908
  3. Insights into the molecular recognition of the 5'-GNN-3' family of DNA sequences by zinc finger domains. Dreier B, et al. J Mol Biol, 2000 Nov 3. PMID 11054286
  4. Expression of FAM83H and ZNF16 are associated with shorter survival of patients with gallbladder carcinoma. Ahn SW, et al. Diagn Pathol, 2020 May 27. PMID 32460791, Free PMC Article
  5. ZNF16 (HZF1) promotes erythropoiesis and megakaryocytopoiesis via regulation of the c-KIT gene. Chen J, et al. Biochem J, 2014 Feb 15. PMID 24180487

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of FAM83H and ZNF16 are associated with shorter survival of patients with gallbladder carcinoma.
    Title: Expression of FAM83H and ZNF16 are associated with shorter survival of patients with gallbladder carcinoma.
  2. Exome sequencing identifies new somatic alterations and mutation patterns of tongue squamous cell carcinoma in a Chinese population.
    Title: Exome sequencing identifies new somatic alterations and mutation patterns of tongue squamous cell carcinoma in a Chinese population.
  3. study demonstrate that ZNF16 plays an important role in erythropoiesis and megakaryocytopoiesis via its regulation of the c-Kit/c-Raf/MEK/ERK/c-Jun/HEY1/GATA1 cascade
    Title: ZNF16 (HZF1) promotes erythropoiesis and megakaryocytopoiesis via regulation of the c-KIT gene.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to sodium dodecyl sulfate IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell cycle phase transition IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of megakaryocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 16
Names
zinc finger protein KOX9
zinc finger protein Kruppel type 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029976.3 → NP_001025147.2  zinc finger protein 16 isoform 1

    See identical proteins and their annotated locations for NP_001025147.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longer transcript variant and encodes the same protein, as compared to transcript variant 1.
    Source sequence(s)
    BC010996, DQ117529
    Consensus CDS
    CCDS6437.1
    UniProtKB/Swiss-Prot
    B3KXM4, D3DWP2, P17020, Q45SH7, Q96FG0, Q9NRA4
    Related
    ENSP00000276816.4, ENST00000276816.8
    Conserved Domains (2) summary
    COG5048
    Location:303 → 675
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:323 → 343
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001413564.1 → NP_001400493.1  zinc finger protein 16 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AF235103
    UniProtKB/Swiss-Prot
    B3KXM4, D3DWP2, P17020, Q45SH7, Q96FG0, Q9NRA4

  3. NM_001413565.1 → NP_001400494.1  zinc finger protein 16 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AF235103
    UniProtKB/Swiss-Prot
    B3KXM4, D3DWP2, P17020, Q45SH7, Q96FG0, Q9NRA4

  4. NM_001413566.1 → NP_001400495.1  zinc finger protein 16 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AF235103
    UniProtKB/Swiss-Prot
    B3KXM4, D3DWP2, P17020, Q45SH7, Q96FG0, Q9NRA4

  5. NM_001413567.1 → NP_001400496.1  zinc finger protein 16 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AF235103

  6. NM_006958.3 → NP_008889.2  zinc finger protein 16 isoform 1

    See identical proteins and their annotated locations for NP_008889.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an alternate exon in the 5' UTR and encodes the same protein, as compared to transcript variant 2.
    Source sequence(s)
    AF244088, AK127625
    Consensus CDS
    CCDS6437.1
    UniProtKB/Swiss-Prot
    B3KXM4, D3DWP2, P17020, Q45SH7, Q96FG0, Q9NRA4
    Related
    ENSP00000378369.2, ENST00000394909.7
    Conserved Domains (2) summary
    COG5048
    Location:303 → 675
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:323 → 343
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    144930358..144950880 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    146104378..146126046 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17020.3 GenPept UniProtKB/Swiss-Prot:P17020

Gene LinkOut

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