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Fastkd2 FAST kinase domains 2 [ Mus musculus (house mouse) ]

Gene ID: 75619, updated on 21-Apr-2024

Summary

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Official Symbol
Fastkd2provided by MGI
Official Full Name
FAST kinase domains 2provided by MGI
Primary source
MGI:MGI:1922869
See related
Ensembl:ENSMUSG00000025962 AllianceGenome:MGI:1922869
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810421I24Rik
Summary
Predicted to enable rRNA binding activity. Predicted to be involved in several processes, including mitochondrial gene expression; mitochondrial large ribosomal subunit assembly; and posttranscriptional regulation of gene expression. Predicted to act upstream of or within ribosome biogenesis. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and respiratory system. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency. Orthologous to human FASTKD2 (FAST kinase domains 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 6.3), CNS E11.5 (RPKM 5.2) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 C2; 1 32.31 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (63769758..63792544)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (63730599..63753385)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene dystrotelin Neighboring gene STARR-seq mESC enhancer starr_01143 Neighboring gene malate dehydrogenase 1B, NAD (soluble) Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:63777041-63777224 Neighboring gene RIKEN cDNA 4933402D24 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:63810015-63810202 Neighboring gene STARR-seq mESC enhancer starr_01145 Neighboring gene ribosomal protein S2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration. Simarro M, et al. Biochem Biophys Res Commun, 2010 Oct 22. PMID 20869947, Free PMC Article
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  3. Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins. Lang B, et al. Nucleic Acids Res, 2021 Jul 9. PMID 34133714, Free PMC Article
  4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables rRNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial RNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial large ribosomal subunit assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial translation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitochondrial translation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitochondrial mRNA stability IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
is_active_in ribonucleoprotein granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
FAST kinase domain-containing protein 2, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172422.3 → NP_766010.1  FAST kinase domain-containing protein 2, mitochondrial

    See identical proteins and their annotated locations for NP_766010.1

    Status: VALIDATED

    Source sequence(s)
    AK035322, AK084971, AK148224
    Consensus CDS
    CCDS15001.1
    UniProtKB/Swiss-Prot
    Q3TLQ2, Q3U526, Q3UFY6, Q8BT79, Q8C3T6, Q922E6
    UniProtKB/TrEMBL
    Q6ZQ14
    Related
    ENSMUSP00000027103.7, ENSMUST00000027103.7
    Conserved Domains (3) summary
    smart00952
    Location:619 → 675
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:443 → 512
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:561 → 596
    FAST_2; FAST kinase-like protein, subdomain 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    63769758..63792544
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496313.2 → XP_006496376.2  FAST kinase domain-containing protein 2, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q6ZQ14
    Related
    ENSMUST00000128621.8
    Conserved Domains (3) summary
    smart00952
    Location:584 → 640
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:408 → 477
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:494 → 561
    FAST_2; FAST kinase-like protein, subdomain 2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q922E6.2 GenPept UniProtKB/Swiss-Prot:Q922E6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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