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Med25 mediator complex subunit 25 [ Mus musculus (house mouse) ]

Gene ID: 75613, updated on 3-Apr-2024

Summary

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Official Symbol
Med25provided by MGI
Official Full Name
mediator complex subunit 25provided by MGI
Primary source
MGI:MGI:1922863
See related
Ensembl:ENSMUSG00000002968 AllianceGenome:MGI:1922863
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ESTM2; 2610034E13Rik; 2610529E18Rik
Summary
Enables retinoid X receptor binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Part of transcription regulator complex. Is expressed in central nervous system; incisor; submandibular gland primordium; and tail dorsal root ganglion. Orthologous to human MED25 (mediator complex subunit 25). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 84.2), ovary adult (RPKM 55.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B3; 7 28.95 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44526189..44544771, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44876765..44892705, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52112565-52112765 Neighboring gene AKT1 substrate 1 Neighboring gene microRNA 707 Neighboring gene polynucleotide kinase 3'- phosphatase Neighboring gene prostate tumor over expressed gene 1 Neighboring gene STARR-positive B cell enhancer ABC_E8171 Neighboring gene STARR-positive B cell enhancer ABC_E547 Neighboring gene fuzzy planar cell polarity protein Neighboring gene adaptor-related protein complex 2, alpha 1 subunit Neighboring gene STARR-positive B cell enhancer ABC_E88 Neighboring gene testis-specific serine kinase substrate

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Med25 Limits Master Regulators That Govern Adipogenesis. Saunders J, et al. Int J Mol Sci, 2023 Mar 24. PMID 37047128, Free PMC Article
  2. MED25 is a mediator component of HNF4α-driven transcription leading to insulin secretion in pancreatic beta-cells. Han EH, et al. PLoS One, 2012. PMID 22952853, Free PMC Article
  3. Identification of the variant Ala335Val of MED25 as responsible for CMT2B2: molecular data, functional studies of the SH3 recognition motif and correlation between wild-type MED25 and PMP22 RNA levels in CMT1A animal models. Leal A, et al. Neurogenetics, 2009 Oct. PMID 19290556, Free PMC Article
  4. Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25. Nakamura Y, et al. Nat Commun, 2011. PMID 21427722, Free PMC Article
  5. MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation. Lee HK, et al. EMBO J, 2007 Aug 8. PMID 17641689, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Med25 Limits Master Regulators That Govern Adipogenesis.
    Title: Med25 Limits Master Regulators That Govern Adipogenesis.
  2. the identification of MED25 as one of the HNF4alpha binding partners in pancreatic ss-cells leading to insulin secretion which is impaired in MODY patients
    Title: MED25 is a mediator component of HNF4α-driven transcription leading to insulin secretion in pancreatic beta-cells.
  3. Data show that Med25 is coordinately expressed with Pmp22 gene dosage and expression in transgenic mice and rats, and suggest a potential role of this protein in the molecular etiology of Charcot-Marie-Tooth disease.
    Title: Identification of the variant Ala335Val of MED25 as responsible for CMT2B2: molecular data, functional studies of the SH3 recognition motif and correlation between wild-type MED25 and PMP22 RNA levels in CMT1A animal models.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nuclear retinoic acid receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nuclear retinoic acid receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear retinoid X receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nuclear retinoid X receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of chromatin binding ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mediator complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription elongation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of core mediator complex ISO
Inferred from Sequence Orthology
more info
  
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription regulator complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
mediator of RNA polymerase II transcription subunit 25
Names
mediator of RNA polymerase II transcription, subunit 9 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001331206.2 → NP_001318135.1  mediator of RNA polymerase II transcription subunit 25 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC158231
    UniProtKB/TrEMBL
    A0A140LHQ0

  2. NM_001331207.2 → NP_001318136.1  mediator of RNA polymerase II transcription subunit 25 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC158231
    Consensus CDS
    CCDS90228.1
    UniProtKB/TrEMBL
    A0A140LHG7, A0A140LHQ0
    Related
    ENSMUSP00000146405.2, ENSMUST00000208253.2

  3. NM_001331208.2 → NP_001318137.1  mediator of RNA polymerase II transcription subunit 25 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC158231
    Consensus CDS
    CCDS85291.1
    UniProtKB/Swiss-Prot
    Q8VCB2
    Related
    ENSMUSP00000146595.2, ENSMUST00000207278.2
    Conserved Domains (5) summary
    pfam09770
    Location:459 → 586
    PAT1; Topoisomerase II-associated protein PAT1
    pfam11232
    Location:297 → 442
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
    pfam11235
    Location:125 → 280
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam11244
    Location:530 → 618
    Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
    cl00057
    Location:1 → 123
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  4. NM_001415795.1 → NP_001402724.1  mediator of RNA polymerase II transcription subunit 25 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC158231

  5. NM_029365.4 → NP_083641.1  mediator of RNA polymerase II transcription subunit 25 isoform 1

    See identical proteins and their annotated locations for NP_083641.1

    Status: VALIDATED

    Source sequence(s)
    AC158231
    Consensus CDS
    CCDS21220.1
    UniProtKB/Swiss-Prot
    Q3UDX6, Q3UFQ1, Q6IR27, Q8VCB2
    UniProtKB/TrEMBL
    A0A140LHQ0
    Related
    ENSMUSP00000003049.7, ENSMUST00000003049.8
    Conserved Domains (4) summary
    pfam11232
    Location:400 → 545
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
    pfam11235
    Location:228 → 383
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam11244
    Location:663 → 745
    Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
    pfam11265
    Location:13 → 225
    Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44526189..44544771 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017312366.3 → XP_017167855.1  mediator of RNA polymerase II transcription subunit 25 isoform X1

    UniProtKB/TrEMBL
    A0A140LHQ0
    Conserved Domains (5) summary
    pfam09770
    Location:620 → 779
    PAT1; Topoisomerase II-associated protein PAT1
    pfam11232
    Location:460 → 605
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
    pfam11235
    Location:287 → 443
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam11244
    Location:717 → 773
    Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
    pfam11265
    Location:74 → 285
    Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A

  2. XM_030243066.2 → XP_030098926.1  mediator of RNA polymerase II transcription subunit 25 isoform X2

    UniProtKB/TrEMBL
    A0A140LHQ0
    Conserved Domains (5) summary
    pfam09770
    Location:618 → 750
    PAT1; Topoisomerase II-associated protein PAT1
    pfam11232
    Location:459 → 604
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
    pfam11235
    Location:287 → 442
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam11244
    Location:692 → 748
    Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
    pfam11265
    Location:74 → 285
    Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A

  3. XM_036153534.1 → XP_036009427.1  mediator of RNA polymerase II transcription subunit 25 isoform X7

    UniProtKB/TrEMBL
    A0A140LHQ0
    Conserved Domains (6) summary
    pfam09770
    Location:483 → 614
    PAT1; Topoisomerase II-associated protein PAT1
    pfam11232
    Location:297 → 442
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
    pfam11235
    Location:125 → 280
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam11244
    Location:554 → 610
    Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
    pfam18658
    Location:625 → 683
    zf-C2H2_12; Zinc-finger C2H2-type
    cl00057
    Location:1 → 123
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  4. XM_030243068.2 → XP_030098928.1  mediator of RNA polymerase II transcription subunit 25 isoform X8

    Conserved Domains (5) summary
    pfam09770
    Location:460 → 589
    PAT1; Topoisomerase II-associated protein PAT1
    pfam11232
    Location:298 → 443
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
    pfam11235
    Location:125 → 281
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam11244
    Location:531 → 587
    Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
    cl00057
    Location:1 → 123
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  5. XM_006541265.4 → XP_006541328.1  mediator of RNA polymerase II transcription subunit 25 isoform X6

    UniProtKB/TrEMBL
    A0A140LHQ0
    Conserved Domains (5) summary
    pfam09770
    Location:458 → 617
    PAT1; Topoisomerase II-associated protein PAT1
    pfam11232
    Location:298 → 443
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
    pfam11235
    Location:125 → 281
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam11244
    Location:555 → 611
    Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
    cl00057
    Location:1 → 123
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  6. XM_030243067.2 → XP_030098927.1  mediator of RNA polymerase II transcription subunit 25 isoform X7

    UniProtKB/TrEMBL
    A0A140LHQ0
    Conserved Domains (6) summary
    pfam09770
    Location:483 → 614
    PAT1; Topoisomerase II-associated protein PAT1
    pfam11232
    Location:297 → 442
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
    pfam11235
    Location:125 → 280
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam11244
    Location:554 → 610
    Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
    pfam18658
    Location:625 → 683
    zf-C2H2_12; Zinc-finger C2H2-type
    cl00057
    Location:1 → 123
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  7. XM_017312368.2 → XP_017167857.1  mediator of RNA polymerase II transcription subunit 25 isoform X6

    UniProtKB/TrEMBL
    A0A140LHQ0
    Conserved Domains (5) summary
    pfam09770
    Location:458 → 617
    PAT1; Topoisomerase II-associated protein PAT1
    pfam11232
    Location:298 → 443
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
    pfam11235
    Location:125 → 281
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam11244
    Location:555 → 611
    Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
    cl00057
    Location:1 → 123
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  8. XM_006541264.3 → XP_006541327.1  mediator of RNA polymerase II transcription subunit 25 isoform X5

    UniProtKB/TrEMBL
    A0A140LHQ0
    Conserved Domains (5) summary
    pfam09770
    Location:621 → 748
    PAT1; Topoisomerase II-associated protein PAT1
    pfam11232
    Location:459 → 604
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
    pfam11235
    Location:287 → 442
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam11244
    Location:692 → 780
    Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
    pfam11265
    Location:74 → 285
    Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A

  9. XM_017312367.3 → XP_017167856.1  mediator of RNA polymerase II transcription subunit 25 isoform X4

    UniProtKB/TrEMBL
    A0A140LHQ0
    Conserved Domains (5) summary
    pfam09770
    Location:622 → 749
    PAT1; Topoisomerase II-associated protein PAT1
    pfam11232
    Location:460 → 605
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
    pfam11235
    Location:287 → 443
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam11244
    Location:693 → 781
    Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
    pfam11265
    Location:74 → 285
    Med25_VWA; Mediator complex subunit 25 von Willebrand factor type A

  10. XM_030243073.2 → XP_030098933.1  mediator of RNA polymerase II transcription subunit 25 isoform X12

    Conserved Domains (5) summary
    pfam09770
    Location:459 → 586
    PAT1; Topoisomerase II-associated protein PAT1
    pfam11232
    Location:297 → 442
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
    pfam11235
    Location:125 → 280
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam11244
    Location:530 → 618
    Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
    cl00057
    Location:1 → 123
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  11. XM_030243070.2 → XP_030098930.1  mediator of RNA polymerase II transcription subunit 25 isoform X10

    UniProtKB/TrEMBL
    A0A140LHQ0
    Conserved Domains (5) summary
    pfam09770
    Location:457 → 595
    PAT1; Topoisomerase II-associated protein PAT1
    pfam11232
    Location:297 → 442
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
    pfam11235
    Location:125 → 280
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam11244
    Location:554 → 642
    Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
    cl00057
    Location:1 → 123
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  12. XM_030243071.2 → XP_030098931.1  mediator of RNA polymerase II transcription subunit 25 isoform X10

    UniProtKB/TrEMBL
    A0A140LHQ0
    Conserved Domains (5) summary
    pfam09770
    Location:457 → 595
    PAT1; Topoisomerase II-associated protein PAT1
    pfam11232
    Location:297 → 442
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
    pfam11235
    Location:125 → 280
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam11244
    Location:554 → 642
    Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
    cl00057
    Location:1 → 123
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  13. XM_030243072.2 → XP_030098932.1  mediator of RNA polymerase II transcription subunit 25 isoform X11

    Conserved Domains (5) summary
    pfam09770
    Location:460 → 587
    PAT1; Topoisomerase II-associated protein PAT1
    pfam11232
    Location:298 → 443
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
    pfam11235
    Location:125 → 281
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam11244
    Location:531 → 619
    Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
    cl00057
    Location:1 → 123
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  14. XM_030243069.2 → XP_030098929.1  mediator of RNA polymerase II transcription subunit 25 isoform X9

    UniProtKB/TrEMBL
    A0A140LHQ0
    Conserved Domains (5) summary
    pfam09770
    Location:458 → 596
    PAT1; Topoisomerase II-associated protein PAT1
    pfam11232
    Location:298 → 443
    Med25; Mediator complex subunit 25 PTOV activation and synapsin 2
    pfam11235
    Location:125 → 281
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam11244
    Location:555 → 643
    Med25_NR-box; Mediator complex subunit 25 C-terminal NR box-containing
    cl00057
    Location:1 → 123
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCB2.1 GenPept UniProtKB/Swiss-Prot:Q8VCB2

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