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Malsu1 mitochondrial assembly of ribosomal large subunit 1 [ Mus musculus (house mouse) ]

Gene ID: 75593, updated on 5-Mar-2024

Summary

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Official Symbol
Malsu1provided by MGI
Official Full Name
mitochondrial assembly of ribosomal large subunit 1provided by MGI
Primary source
MGI:MGI:1922843
See related
Ensembl:ENSMUSG00000029815 AllianceGenome:MGI:1922843
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Matsu1; 2410003K15Rik
Summary
Predicted to enable ribosomal large subunit binding activity. Predicted to be involved in negative regulation of mitochondrial translation; negative regulation of ribosome biogenesis; and ribosomal large subunit biogenesis. Predicted to act upstream of or within ribosome biogenesis. Predicted to be located in cytosol. Predicted to be part of mitochondrial large ribosomal subunit. Predicted to be active in mitochondrion. Orthologous to human MALSU1 (mitochondrial assembly of ribosomal large subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 7.4), adrenal adult (RPKM 6.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 B2.3; 6 23.82 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (49050729..49116078)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (49073795..49139144)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6428 Neighboring gene glycoprotein (transmembrane) nmb Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:49023701-49023810 Neighboring gene STARR-seq mESC enhancer starr_15807 Neighboring gene mitochondrial ribosomal protein S36 pseudogene Neighboring gene predicted gene 7890 Neighboring gene STARR-seq mESC enhancer starr_15808 Neighboring gene insulin-like growth factor 2 mRNA binding protein 3 Neighboring gene STARR-seq mESC enhancer starr_15813 Neighboring gene predicted gene, 18010 Neighboring gene RIKEN cDNA D030074P21 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:49158708-49158891

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization. Powles N, et al. Dev Biol, 2004 Apr 1. PMID 15031102
  2. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mitochondrial large ribosomal subunit binding ISO
Inferred from Sequence Orthology
more info
  
enables ribosomal large subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of mitochondrial translation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ribosome biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal large subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial assembly of ribosomal large subunit protein 1
Names
protein C7orf30 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029353.1 → NP_083629.1  mitochondrial assembly of ribosomal large subunit protein 1

    See identical proteins and their annotated locations for NP_083629.1

    Status: VALIDATED

    Source sequence(s)
    AK010366, AV085631, BY036157
    Consensus CDS
    CCDS51768.1
    UniProtKB/Swiss-Prot
    Q9CWV0
    Related
    ENSMUSP00000122941.3, ENSMUST00000128616.6
    Conserved Domains (1) summary
    pfam02410
    Location:89 → 188
    RsfS; Ribosomal silencing factor during starvation

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    49050729..49116078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506721.1 → XP_006506784.1  mitochondrial assembly of ribosomal large subunit protein 1 isoform X1

    Conserved Domains (1) summary
    pfam02410
    Location:89 → 188
    RsfS; Ribosomal silencing factor during starvation

  2. XM_006506722.3 → XP_006506785.1  mitochondrial assembly of ribosomal large subunit protein 1 isoform X2

    Conserved Domains (1) summary
    pfam02410
    Location:89 → 188
    RsfS; Ribosomal silencing factor during starvation

  3. XM_036152386.1 → XP_036008279.1  mitochondrial assembly of ribosomal large subunit protein 1 isoform X3

  4. XM_011241499.3 → XP_011239801.1  mitochondrial assembly of ribosomal large subunit protein 1 isoform X4

    Conserved Domains (1) summary
    pfam02410
    Location:22 → 69
    RsfS; Ribosomal silencing factor during starvation
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CWV0.1 GenPept UniProtKB/Swiss-Prot:Q9CWV0

Gene LinkOut

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