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Acyp2 acylphosphatase 2, muscle type [ Mus musculus (house mouse) ]

Gene ID: 75572, updated on 11-Apr-2024

Summary

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Official Symbol
Acyp2provided by MGI
Official Full Name
acylphosphatase 2, muscle typeprovided by MGI
Primary source
MGI:MGI:1922822
See related
Ensembl:ENSMUSG00000060923 AllianceGenome:MGI:1922822
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310004B09Rik
Summary
Predicted to enable acylphosphatase activity and identical protein binding activity. Located in mitochondrion. Is expressed in cranial ganglion; integumental system; musculoskeletal system; and salivary gland. Orthologous to human ACYP2 (acylphosphatase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 12.3), heart adult (RPKM 11.0) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Acyp2 in Genome Data Viewer
Location:
11 A4; 11 18.16 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (30455991..30599778, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (30505992..30649608, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene stress-induced phosphoprotein 1 pseudogene Neighboring gene RIKEN cDNA 4930505A04 gene Neighboring gene STARR-seq mESC enhancer starr_29059 Neighboring gene predicted gene, 53677 Neighboring gene STARR-seq mESC enhancer starr_29061 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 pseudogene Neighboring gene Pea15a pseudogene Neighboring gene RNA binding motif protein pseudogene Neighboring gene coiled-coil domain containing 47 pseudogene Neighboring gene STARR-seq mESC enhancer starr_29063 Neighboring gene STARR-seq mESC enhancer starr_29064 Neighboring gene STARR-seq mESC enhancer starr_29065 Neighboring gene ribosomal protein L7-like 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_29066 Neighboring gene STARR-seq mESC enhancer starr_29067 Neighboring gene predicted gene 12100

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
  2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acylphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
acylphosphatase-2
Names
acylphosphatase, muscle type isozyme
acylphosphate phosphohydrolase 2
NP_083620.1
XP_017170305.1
XP_036012948.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029344.4 → NP_083620.1  acylphosphatase-2

    See identical proteins and their annotated locations for NP_083620.1

    Status: VALIDATED

    Source sequence(s)
    AL732595, AL844147
    Consensus CDS
    CCDS24507.1
    UniProtKB/Swiss-Prot
    P56375, Q5SPV7, Q8BQX2
    Related
    ENSMUSP00000074195.4, ENSMUST00000074613.4
    Conserved Domains (1) summary
    pfam00708
    Location:13 → 105
    Acylphosphatase; Acylphosphatase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    30455991..30599778 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157055.1 → XP_036012948.1  acylphosphatase-2 isoform X1

    Conserved Domains (1) summary
    cl00551
    Location:17 → 76
    Acylphosphatase

  2. XM_017314816.3 → XP_017170305.1  acylphosphatase-2 isoform X1

    Conserved Domains (1) summary
    cl00551
    Location:17 → 76
    Acylphosphatase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56375.2 GenPept UniProtKB/Swiss-Prot:P56375

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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