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Nat8f4 N-acetyltransferase 8 (GCN5-related) family member 4 [ Mus musculus (house mouse) ]

Gene ID: 75541, updated on 8-Feb-2024

Summary

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Official Symbol
Nat8f4provided by MGI
Official Full Name
N-acetyltransferase 8 (GCN5-related) family member 4provided by MGI
Primary source
MGI:MGI:1922791
See related
Ensembl:ENSMUSG00000068299 AllianceGenome:MGI:1922791
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700019G17Rik
Summary
Predicted to enable cysteine-S-conjugate N-acetyltransferase activity and lysine N-acetyltransferase activity, acting on acetyl phosphate as donor. Predicted to be involved in several processes, including negative regulation of apoptotic process; peptide metabolic process; and peptidyl-lysine N6-acetylation. Predicted to be located in endoplasmic reticulum membrane and endoplasmic reticulum-Golgi intermediate compartment membrane. Predicted to be integral component of membrane. Orthologous to human NAT8 (N-acetyltransferase 8 (putative)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 5.1), liver adult (RPKM 3.8) and 21 other tissues See more
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Genomic context

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See Nat8f4 in Genome Data Viewer
Location:
6 C3; 6 37.52 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (85876032..85881920, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (85899050..85909315, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16510 Neighboring gene N-acetyltransferase 8 (GCN5-related) family member 2 Neighboring gene STARR-seq mESC enhancer starr_16511 Neighboring gene 60S ribosomal protein L23a-like Neighboring gene STARR-seq mESC enhancer starr_16512 Neighboring gene STARR-positive B cell enhancer ABC_E11321 Neighboring gene N-acetyltransferase 8 (GCN5-related) family member 1 Neighboring gene Tp53rk binding protein Neighboring gene syndecan binding protein pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. JMJD1C Exhibits Multiple Functions in Epigenetic Regulation during Spermatogenesis. Nakajima R, et al. PLoS One, 2016. PMID 27649575, Free PMC Article
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-S-conjugate N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
N-acetyltransferase family 8 member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145895.1 → NP_001139367.1  N-acetyltransferase family 8 member 4 isoform 2

    See identical proteins and their annotated locations for NP_001139367.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR segment and lacks an internal coding segment, as compared to variant 1. The resulting isoform (2) has a shorter and different C-terminus, as compared to isoform 1.
    Source sequence(s)
    AC161888
    Consensus CDS
    CCDS51831.1
    UniProtKB/TrEMBL
    E0CYM0
    Related
    ENSMUSP00000124071.2, ENSMUST00000159755.8

  2. NM_029331.3 → NP_083607.3  N-acetyltransferase family 8 member 4 isoform 1

    See identical proteins and their annotated locations for NP_083607.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC161888
    Consensus CDS
    CCDS39540.1
    UniProtKB/TrEMBL
    G5E8L3, Q8CID2
    Related
    ENSMUSP00000093430.4, ENSMUST00000095757.4
    Conserved Domains (1) summary
    pfam00583
    Location:82 → 192
    Acetyltransf_1; Acetyltransferase (GNAT) family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    85876032..85881920 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506720.5 → XP_006506783.1  N-acetyltransferase family 8 member 4 isoform X1

    See identical proteins and their annotated locations for XP_006506783.1

    UniProtKB/TrEMBL
    G5E8L3, Q8CID2
    Conserved Domains (1) summary
    pfam00583
    Location:82 → 192
    Acetyltransf_1; Acetyltransferase (GNAT) family
Nucleotide Protein Strain
Heading Accession and Version

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