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Syce3 synaptonemal complex central element protein 3 [ Mus musculus (house mouse) ]

Gene ID: 75459, updated on 5-Mar-2024

Summary

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Official Symbol
Syce3provided by MGI
Official Full Name
synaptonemal complex central element protein 3provided by MGI
Primary source
MGI:MGI:1922709
See related
Ensembl:ENSMUSG00000078938 AllianceGenome:MGI:1922709
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TSEG2; TSEG-2; 1700007E06Rik
Summary
Involved in reciprocal meiotic recombination; spermatogenesis; and synaptonemal complex assembly. Acts upstream of or within positive regulation of apoptotic process. Located in central element. Is expressed in embryo and testis. Orthologous to human SYCE3 (synaptonemal complex central element protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 52.2) See more
Orthologs
human all
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Genomic context

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Location:
15 E3; 15 44.87 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (89274377..89294706, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (89390174..89410503, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene ciliary microtubule associated protein 1B Neighboring gene kelch domain containing 7B Neighboring gene predicted readthrough transcript (NMD candidate), 44502 Neighboring gene carnitine palmitoyltransferase 1b, muscle Neighboring gene STARR-positive B cell enhancer ABC_E7406 Neighboring gene choline kinase beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structural maturation of SYCP1-mediated meiotic chromosome synapsis by SYCE3. Crichton JH, et al. Nat Struct Mol Biol, 2023 Feb. PMID 36635604, Free PMC Article
  2. Expression pattern of testis-specific expressed gene 2 in cryptorchidism model and its role in apoptosis of spermatogenic cells. Hu T, et al. J Huazhong Univ Sci Technolog Med Sci, 2010 Apr. PMID 20407872
  3. [Cloning and expression of a novel mouse testis gene TSEG-2]. Wang ZY, et al. Zhonghua Nan Ke Xue, 2009 Feb. PMID 19323366
  4. Elucidation of synaptonemal complex organization by super-resolution imaging with isotropic resolution. Schücker K, et al. Proc Natl Acad Sci U S A, 2015 Feb 17. PMID 25646409, Free PMC Article
  5. Dynamic localization of SMC5/6 complex proteins during mammalian meiosis and mitosis suggests functions in distinct chromosome processes. Gómez R, et al. J Cell Sci, 2013 Sep 15. PMID 23843628, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural maturation of SYCP1-mediated meiotic chromosome synapsis by SYCE3.
    Title: Structural maturation of SYCP1-mediated meiotic chromosome synapsis by SYCE3.
  2. SCRE interacts with synaptonemal complex protein 1 (SYCP1) and synaptonemal complex central element 3 (SYCE3); the function of SCRE is to reinforce the integrity of the central elements, thereby stabilizing the SC and ensuring meiotic cell cycle progression
    Title: SCRE serves as a unique synaptonemal complex fastener and is essential for progression of meiosis prophase I in mice.
  3. TSEG-2 may participate in the apoptosis of spermatogenic cells and the pathogenesis of cryptorchidism.
    Title: Expression pattern of testis-specific expressed gene 2 in cryptorchidism model and its role in apoptosis of spermatogenic cells.
  4. SYCE3 is required for male and female fertility.
    Title: A novel mouse synaptonemal complex protein is essential for loading of central element proteins, recombination, and fertility.
  5. A novel mouse testis specific gene TSEG-2 was successfully cloned, which could be down-regulated by cryptorchidism-inducible 17-beta estradiol. [TSEG-2]
    Title: [Cloning and expression of a novel mouse testis gene TSEG-2].
  6. Transcripts highly enriched in ovary; gene identified as candidate female fertility factor.
    Title: Genomewide discovery and classification of candidate ovarian fertility genes in the mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of ectopic germ cell programmed cell death IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of developmental process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of reproductive process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptonemal complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptonemal complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in central element IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in central element IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
synaptonemal complex central element protein 3
Names
testis-specific expressed protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162880.1 → NP_001156352.1  synaptonemal complex central element protein 3

    See identical proteins and their annotated locations for NP_001156352.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
    Source sequence(s)
    BC048615
    Consensus CDS
    CCDS49703.1
    UniProtKB/Swiss-Prot
    B5KM66
    UniProtKB/TrEMBL
    E7D6R1
    Related
    ENSMUSP00000131766.2, ENSMUST00000167959.2
    Conserved Domains (1) summary
    pfam15191
    Location:1 → 85
    Synaptonemal_3; Synaptonemal complex central element protein 3

  2. NM_001162882.1 → NP_001156354.1  synaptonemal complex central element protein 3

    See identical proteins and their annotated locations for NP_001156354.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AK029781, BC048615
    Consensus CDS
    CCDS49703.1
    UniProtKB/Swiss-Prot
    B5KM66
    UniProtKB/TrEMBL
    E7D6R1
    Related
    ENSMUSP00000104937.3, ENSMUST00000109314.9
    Conserved Domains (1) summary
    pfam15191
    Location:1 → 85
    Synaptonemal_3; Synaptonemal complex central element protein 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    89274377..89294706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B5KM66.1 GenPept UniProtKB/Swiss-Prot:B5KM66

Gene LinkOut

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