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Ascc2 activating signal cointegrator 1 complex subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 75452, updated on 11-Apr-2024

Summary

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Official Symbol
Ascc2provided by MGI
Official Full Name
activating signal cointegrator 1 complex subunit 2provided by MGI
Primary source
MGI:MGI:1922702
See related
Ensembl:ENSMUSG00000020412 AllianceGenome:MGI:1922702
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ASC1p100; 1700011I11Rik; 2610034L15Rik
Summary
Predicted to enable ubiquitin binding activity. Predicted to be involved in regulation of transcription, DNA-templated; rescue of stalled ribosome; and ribosome-associated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within DNA repair. Predicted to be located in nucleus. Predicted to be part of activating signal cointegrator 1 complex. Is expressed in several structures, including adrenal gland; alimentary system; aorta; brain; and genitourinary system. Orthologous to human ASCC2 (activating signal cointegrator 1 complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 15.3), bladder adult (RPKM 12.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 A1; 11 2.94 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (4587698..4635699)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (4637696..4685699)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene myotubularin related protein 3 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E728 Neighboring gene STARR-positive B cell enhancer ABC_E3930 Neighboring gene predicted gene 11961 Neighboring gene STARR-seq mESC enhancer starr_28397 Neighboring gene STARR-seq mESC enhancer starr_28398 Neighboring gene STARR-positive B cell enhancer ABC_E2979 Neighboring gene ubiquinol-cytochrome c reductase, complex III subunit X Neighboring gene zinc finger, matrin type 5 Neighboring gene STARR-seq mESC enhancer starr_28401 Neighboring gene calcium binding protein 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of DNA Damage Repair Enzyme Ascc2 as Causal for Heart Failure With Preserved Ejection Fraction. Cao Y, et al. Circulation, 2022 Apr 5. PMID 35377742, Free PMC Article
  2. Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis. Lee J, et al. Proc Natl Acad Sci U S A, 2008 Dec 9. PMID 19047629, Free PMC Article
  3. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  4. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ASC-2, MLL3, and MLL4 are recruited to the PPARgamma-activated aP2 gene during adipogenesis
    Title: Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21588

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables K63-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome-associated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of DNA repair complex ISO
Inferred from Sequence Orthology
more info
  
part_of activating signal cointegrator 1 complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
activating signal cointegrator 1 complex subunit 2
Names
ASC-1 complex subunit P100
trip4 complex subunit p100

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001376980.1 → NP_001363909.1  activating signal cointegrator 1 complex subunit 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL606521
    UniProtKB/TrEMBL
    Q3UG63
    Conserved Domains (1) summary
    cd14364
    Location:353 → 392
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

  2. NM_029291.2 → NP_083567.1  activating signal cointegrator 1 complex subunit 2 isoform 1

    See identical proteins and their annotated locations for NP_083567.1

    Status: VALIDATED

    Source sequence(s)
    AL606521
    Consensus CDS
    CCDS24387.1
    UniProtKB/Swiss-Prot
    Q5NCK1, Q8BKM9, Q8BX60, Q8R1B9, Q91WR3
    UniProtKB/TrEMBL
    Q3UG63
    Related
    ENSMUSP00000063272.8, ENSMUST00000070257.14
    Conserved Domains (1) summary
    cd14364
    Location:467 → 506
    CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    4587698..4635699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_380985.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91WR3.1 GenPept UniProtKB/Swiss-Prot:Q91WR3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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