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Cfap144 cilia and flagella associated protein 144 [ Mus musculus (house mouse) ]

Gene ID: 75429, updated on 18-Apr-2024

Summary

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Official Symbol
Cfap144provided by MGI
Official Full Name
cilia and flagella associated protein 144provided by MGI
Primary source
MGI:MGI:1922679
See related
Ensembl:ENSMUSG00000049154 AllianceGenome:MGI:1922679
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Theg6; Fam183b; 3100002J23Rik
Summary
Located in centrosome; ciliary basal body; and ciliary base. Is expressed in several structures, including lung; nasal cavity respiratory epithelium; node; notochord; and reproductive system. Orthologous to several human genes including FAM183A (family with sequence similarity 183 member A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 7.7), lung adult (RPKM 0.8) and 1 other tissue See more
Orthologs
human all
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Genomic context

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Location:
11 B1.3; 11 36.3 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (58683628..58692786, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (58783892..58802221, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily T member 45 Neighboring gene olfactory receptor family 2 subfamily T member 44 Neighboring gene olfactory receptor family 5 subfamily AC member 20 Neighboring gene olfactory receptor family 5 subfamily AF member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The evolutionary conserved FOXJ1 target gene Fam183b is essential for motile cilia in Xenopus but dispensable for ciliary function in mice. Beckers A, et al. Sci Rep, 2018 Oct 2. PMID 30279523, Free PMC Article
  2. A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity. Dykes IM, et al. Sci Rep, 2018 Jul 11. PMID 29992973, Free PMC Article
  3. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Stauber M, et al. Dev Biol, 2017 Mar 15. PMID 27914912
  4. Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Tamplin OJ, et al. Dev Biol, 2011 Dec 15. PMID 22008794
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Surprisingly, mice homozygous for a null allele did not display any defects indicative of disrupted motile ciliary function.
    Title: The evolutionary conserved FOXJ1 target gene Fam183b is essential for motile cilia in Xenopus but dispensable for ciliary function in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

General gene information

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Markers

Homology

Clone Names

  • MGC143784

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in axonemal B tubule inner sheath IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axonemal microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in ciliary base IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in ciliary base IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein FAM183B
Names
family with sequence similarity 183, member B
testis highly expressed protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162878.3 → NP_001156350.2  protein FAM183B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL662903
    Consensus CDS
    CCDS48807.2
    Related
    ENSMUSP00000051960.5, ENSMUST00000060581.5
    Conserved Domains (1) summary
    pfam14886
    Location:19 → 101
    FAM183; FAM183A and FAM183B related

  2. NM_029283.3 → NP_083559.2  protein FAM183B isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL662903
    Consensus CDS
    CCDS48808.2
    UniProtKB/Swiss-Prot
    Q3TZB7, Q5NC57, Q9CXW5
    Related
    ENSMUSP00000091708.6, ENSMUST00000094156.12
    Conserved Domains (1) summary
    pfam14886
    Location:19 → 121
    FAM183; FAM183A and FAM183B related

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    58683628..58692786 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5NC57.2 GenPept UniProtKB/Swiss-Prot:Q5NC57

Gene LinkOut

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