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Arl5a ADP-ribosylation factor-like 5A [ Mus musculus (house mouse) ]

Gene ID: 75423, updated on 11-Apr-2024

Summary

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Official Symbol
Arl5aprovided by MGI
Official Full Name
ADP-ribosylation factor-like 5Aprovided by MGI
Primary source
MGI:MGI:1922673
See related
Ensembl:ENSMUSG00000036093 AllianceGenome:MGI:1922673
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Arl5; 2410015N24Rik; 2810410P22Rik
Summary
Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport; protein localization to Golgi membrane; and vesicle-mediated transport. Predicted to be active in trans-Golgi network. Is expressed in several structures, including cranial ganglion; liver lobe; medulla oblongata basal plate; metanephros; and vibrissa. Orthologous to human ARL5A (ADP ribosylation factor like GTPase 5A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 6.4), CNS E18 (RPKM 6.4) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 C1.1; 2 29.98 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (52287961..52314886, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (52397949..52424874, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 13521 Neighboring gene predicted gene 13522 Neighboring gene RIKEN cDNA A430018G15 gene Neighboring gene calcium channel, voltage-dependent, beta 4 subunit Neighboring gene STARR-seq mESC enhancer starr_04483 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 2, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. An 'equalized cDNA library' by the reassociation of short double-stranded cDNAs. Ko MS. Nucleic Acids Res, 1990 Oct 11. PMID 2216762, Free PMC Article
  2. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article
  3. Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Miller JA, et al. Development, 2013 Nov. PMID 24154525, Free PMC Article
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ADP-ribosylation factor-like protein 5A
Names
ADP-ribosylation factor-like 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182994.2 → NP_892039.1  ADP-ribosylation factor-like protein 5A

    See identical proteins and their annotated locations for NP_892039.1

    Status: PROVISIONAL

    Source sequence(s)
    AL845467
    Consensus CDS
    CCDS16033.1
    UniProtKB/Swiss-Prot
    Q80ZU0
    UniProtKB/TrEMBL
    Q498A0
    Related
    ENSMUSP00000041756.8, ENSMUST00000036541.8
    Conserved Domains (2) summary
    cd04153
    Location:3 → 175
    Arl5_Arl8; Arf-like 5 (Arl5) and 8 (Arl8) GTPases
    pfam00071
    Location:18 → 164
    Ras; Ras family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    52287961..52314886 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239204.4 → XP_011237506.1  ADP-ribosylation factor-like protein 5A isoform X1

    Conserved Domains (1) summary
    cl38936
    Location:1 → 138
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80ZU0.1 GenPept UniProtKB/Swiss-Prot:Q80ZU0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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