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Mettl5 methyltransferase 5, N6-adenosine [ Mus musculus (house mouse) ]

Gene ID: 75422, updated on 11-Apr-2024

Summary

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Official Symbol
Mettl5provided by MGI
Official Full Name
methyltransferase 5, N6-adenosineprovided by MGI
Primary source
MGI:MGI:1922672
See related
Ensembl:ENSMUSG00000051730 AllianceGenome:MGI:1922672
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810410A08Rik
Summary
Enables rRNA (adenine-N6-)-methyltransferase activity. Involved in positive regulation of translation; rRNA methylation; and stem cell differentiation. Predicted to be located in nucleus; postsynapse; and presynapse. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder-72. Orthologous to human METTL5 (methyltransferase 5, N6-adenosine). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 10.1), CNS E11.5 (RPKM 8.1) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 C2; 2 40.95 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (69701539..69717961, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (69871195..69886634, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39841 Neighboring gene STARR-positive B cell enhancer mm9_chr2:69698414-69698714 Neighboring gene STARR-positive B cell enhancer ABC_E4462 Neighboring gene kelch-like 23 Neighboring gene STARR-positive B cell enhancer ABC_E11134 Neighboring gene STARR-seq mESC enhancer starr_04746 Neighboring gene STARR-positive B cell enhancer ABC_E508 Neighboring gene STARR-seq mESC enhancer starr_04748 Neighboring gene small RNA binding exonuclease protection factor La Neighboring gene STARR-positive B cell enhancer ABC_E9515 Neighboring gene STARR-seq mESC enhancer starr_04749 Neighboring gene ubiquitin protein ligase E3 component n-recognin 3 Neighboring gene STARR-seq mESC enhancer starr_04750 Neighboring gene STARR-positive B cell enhancer ABC_E4463 Neighboring gene myosin IIIB Neighboring gene STARR-seq mESC enhancer starr_04751 Neighboring gene STARR-seq mESC enhancer starr_04752 Neighboring gene STARR-seq mESC enhancer starr_04756 Neighboring gene STARR-seq mESC enhancer starr_04757

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inhibition of METTL5 improves preimplantation development of mouse somatic cell nuclear transfer embryos. Zhang L, et al. Reproduction, 2022 Nov 1. PMID 36111643
  2. Loss of m(6)A Methyltransferase METTL5 Promotes Cardiac Hypertrophy Through Epitranscriptomic Control of SUZ12 Expression. Han Y, et al. Front Cardiovasc Med, 2022. PMID 35295259, Free PMC Article
  3. The 18S rRNA m(6) A methyltransferase METTL5 promotes mouse embryonic stem cell differentiation. Xing M, et al. EMBO Rep, 2020 Oct 5. PMID 32783360, Free PMC Article
  4. The rRNA m(6)A methyltransferase METTL5 is involved in pluripotency and developmental programs. Ignatova VV, et al. Genes Dev, 2020 May 1. PMID 32217665, Free PMC Article
  5. The METTL5-TRMT112 N(6)-methyladenosine methyltransferase complex regulates mRNA translation via 18S rRNA methylation. Sepich-Poore C, et al. J Biol Chem, 2022 Mar. PMID 35033535, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. METTL5-mediated 18S rRNA m[6]A modification promotes oncogenic mRNA translation and intrahepatic cholangiocarcinoma progression.
    Title: METTL5-mediated 18S rRNA m(6)A modification promotes oncogenic mRNA translation and intrahepatic cholangiocarcinoma progression.
  2. Inhibition of METTL5 improves preimplantation development of mouse somatic cell nuclear transfer embryos.
    Title: Inhibition of METTL5 improves preimplantation development of mouse somatic cell nuclear transfer embryos.
  3. The 18S rRNA m(6) A methyltransferase METTL5 promotes mouse embryonic stem cell differentiation.
    Title: The 18S rRNA m(6) A methyltransferase METTL5 promotes mouse embryonic stem cell differentiation.
  4. The rRNA m(6)A methyltransferase METTL5 is involved in pluripotency and developmental programs.
    Title: The rRNA m(6)A methyltransferase METTL5 is involved in pluripotency and developmental programs.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (8)  1 citation

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables S-adenosyl-L-methionine binding ISO
Inferred from Sequence Orthology
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables rRNA (adenine-N6-)-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables rRNA (adenine-N6-)-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables rRNA (adenine-N6-)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in rRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA methylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in rRNA methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
located_in presynapse ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rRNA N6-adenosine-methyltransferase METTL5
Names
methyltransferase like 5
methyltransferase-like protein 5
NP_083556.2
XP_006500392.1
XP_030108023.1
XP_036018540.1
XP_036018541.1
XP_036018542.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029280.4 → NP_083556.2  rRNA N6-adenosine-methyltransferase METTL5

    See identical proteins and their annotated locations for NP_083556.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the supported protein.
    Source sequence(s)
    AA175151, AA466649, AK013063, AK133594
    Consensus CDS
    CCDS16103.2
    UniProtKB/Swiss-Prot
    Q8K1A0
    Related
    ENSMUSP00000050907.7, ENSMUST00000060447.13
    Conserved Domains (1) summary
    COG2263
    Location:7 → 209
    COG2263; Predicted RNA methylase [General function prediction only]

RNA

  1. NR_110977.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA175151, AA466649, AK013063, AK133594

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    69701539..69717961 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162649.1 → XP_036018542.1  rRNA N6-adenosine-methyltransferase METTL5 isoform X4

    UniProtKB/TrEMBL
    D6RCI3, Q3UZW4
    Related
    ENSMUSP00000121474.2, ENSMUST00000142127.8
    Conserved Domains (1) summary
    cl17173
    Location:7 → 136
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. XM_036162648.1 → XP_036018541.1  rRNA N6-adenosine-methyltransferase METTL5 isoform X3

    UniProtKB/TrEMBL
    Q3UZW4
    Conserved Domains (1) summary
    cl17173
    Location:7 → 167
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  3. XM_030252163.2 → XP_030108023.1  rRNA N6-adenosine-methyltransferase METTL5 isoform X2

    UniProtKB/Swiss-Prot
    Q8K1A0
    Conserved Domains (1) summary
    COG2263
    Location:7 → 209
    COG2263; Predicted RNA methylase [General function prediction only]

  4. XM_006500329.5 → XP_006500392.1  rRNA N6-adenosine-methyltransferase METTL5 isoform X1

    Conserved Domains (1) summary
    COG2263
    Location:7 → 204
    COG2263; Predicted RNA methylase [General function prediction only]

  5. XM_036162647.1 → XP_036018540.1  rRNA N6-adenosine-methyltransferase METTL5 isoform X1

    Conserved Domains (1) summary
    COG2263
    Location:7 → 204
    COG2263; Predicted RNA methylase [General function prediction only]

RNA

  1. XR_004940759.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K1A0.2 GenPept UniProtKB/Swiss-Prot:Q8K1A0

Gene LinkOut

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