Sirt4 sirtuin 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sirt4provided by MGI
Official Full Name: sirtuin 4provided by MGI
Primary source: MGI:MGI:1922637
See related: Ensembl:ENSMUSG00000029524 AllianceGenome:MGI:1922637
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4930596O17Rik
Summary: Enables NAD+ ADP-ribosyltransferase activity; NAD-dependent protein deacetylase activity; and lipoamidase activity. Involved in several processes, including carboxylic acid metabolic process; cellular protein modification process; and regulation of cellular ketone metabolic process. Acts upstream of or within negative regulation of insulin secretion. Located in mitochondrial inner membrane and mitochondrial matrix. Is expressed in several structures, including gonad; heart; nervous system; respiratory system; and thyroid gland. Orthologous to human SIRT4 (sirtuin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in cerebellum adult (RPKM 8.3), bladder adult (RPKM 7.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 56.1 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (115616065..115628322, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (115478006..115490264, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sirtuin 4 (Sirt4) downregulation contributes to chondrocyte senescence and osteoarthritis via mediating mitochondrial dysfunction.
Title: Sirtuin 4 (Sirt4) downregulation contributes to chondrocyte senescence and osteoarthritis via mediating mitochondrial dysfunction.
Sirtuin4 alleviates severe acute pancreatitis by regulating HIF-1alpha/HO-1 mediated ferroptosis.
Title: Sirtuin4 alleviates severe acute pancreatitis by regulating HIF-1α/HO-1 mediated ferroptosis.
Sirt4 deficiency promotes the development of atherosclerosis by activating the NF-kappaB/IkappaB/CXCL2/3 pathway.
Title: Sirt4 deficiency promotes the development of atherosclerosis by activating the NF-κB/IκB/CXCL2/3 pathway.
Downregulation of lncRNA MALAT1 Inhibits Angiotensin II-induced Hypertrophic Effects of Cardiomyocytes by Regulating SIRT4 via miR-93-5p.
Title: Downregulation of lncRNA MALAT1 Inhibits Angiotensin II-induced Hypertrophic Effects of Cardiomyocytes by Regulating SIRT4 via miR-93-5p.
SIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis.
Title: SIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis.
miRNA-130b-5p promotes hepatic stellate cell activation and the development of liver fibrosis by suppressing SIRT4 expression.
Title: miRNA-130b-5p promotes hepatic stellate cell activation and the development of liver fibrosis by suppressing SIRT4 expression.
FOXM1-activated SIRT4 inhibits NF-kappaB signaling and NLRP3 inflammasome to alleviate kidney injury and podocyte pyroptosis in diabetic nephropathy.
Title: FOXM1-activated SIRT4 inhibits NF-κB signaling and NLRP3 inflammasome to alleviate kidney injury and podocyte pyroptosis in diabetic nephropathy.
Differential expressions of SIRT1, SIRT3, and SIRT4 in peripheral blood mononuclear cells from patients with type 2 diabetic retinopathy.
Title: Differential expressions of SIRT1, SIRT3, and SIRT4 in peripheral blood mononuclear cells from patients with type 2 diabetic retinopathy.
Glucose-induced oxidative stress and accelerated aging in endothelial cells are mediated by the depletion of mitochondrial SIRTs.
Title: Glucose-induced oxidative stress and accelerated aging in endothelial cells are mediated by the depletion of mitochondrial SIRTs.
beta-Cell-specific ablation of sirtuin 4 does not affect nutrient-stimulated insulin secretion in mice.
Title: β-Cell-specific ablation of sirtuin 4 does not affect nutrient-stimulated insulin secretion in mice.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sirt4 (e-PCR), detects polymorphism
- UniSTS:531296

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables NAD+ ADP-ribosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables NAD+ ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables NAD+ binding	IEA Inferred from Electronic Annotation more info
enables NAD-dependent protein biotinidase activity	ISO Inferred from Sequence Orthology more info
enables NAD-dependent protein deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables NAD-dependent protein lipoamidase activity	ISO Inferred from Sequence Orthology more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone deacetylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lipoamidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein lysine deacetylase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in epigenetic regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cardiac muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fatty acid oxidation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of fatty acid oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fatty acid oxidation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of insulin secretion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein processing involved in protein targeting to mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine deacetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of lipid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of glutamine family amino acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of pyruvate dehydrogenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of pyruvate dehydrogenase activity	ISO Inferred from Sequence Orthology more info
involved_in tricarboxylic acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

Names: NAD-dependent protein biotinylase sirtuin-4

NP_001161163.1

EC 2.3.1.286

NP_598521.1

EC 2.3.1.286

XP_006530543.1

EC 2.3.1.286

XP_006530544.1

EC 2.3.1.286

XP_017176616.1

EC 2.3.1.286

XP_030110726.1

EC 2.3.1.286

XP_030110728.1

EC 2.3.1.286

XP_036021467.1

EC 2.3.1.286

XP_036021468.1

EC 2.3.1.286

XP_036021469.1

EC 2.3.1.286

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001167691.1 → NP_001161163.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

See identical proteins and their annotated locations for NP_001161163.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC117735, AC159539

Consensus CDS

CCDS51628.1

UniProtKB/Swiss-Prot

D3Z1D9, Q8R216

Related

ENSMUSP00000107698.2, ENSMUST00000112067.8

Conserved Domains (1) summary

cd01409
Location:44 → 305

SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
NM_133760.1 → NP_598521.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

See identical proteins and their annotated locations for NP_598521.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC117735, AC159539

Consensus CDS

CCDS51628.1

UniProtKB/Swiss-Prot

D3Z1D9, Q8R216

Related

ENSMUSP00000107697.2, ENSMUST00000112066.2

Conserved Domains (1) summary

cd01409
Location:44 → 305

SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

115616065..115628322 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030254868.2 → XP_030110728.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X5

UniProtKB/Swiss-Prot

D3Z1D9, Q8R216

Conserved Domains (1) summary

cd01409
Location:44 → 305

SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
XM_017321127.3 → XP_017176616.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X5

UniProtKB/Swiss-Prot

D3Z1D9, Q8R216

Conserved Domains (1) summary

cd01409
Location:44 → 305

SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
XM_036165575.1 → XP_036021468.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X2

Conserved Domains (1) summary

cd01409
Location:85 → 356

SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
XM_030254866.2 → XP_030110726.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X4

Conserved Domains (1) summary

cd01409
Location:44 → 315

SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
XM_006530480.4 → XP_006530543.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X4

See identical proteins and their annotated locations for XP_006530543.1

Conserved Domains (1) summary

cd01409
Location:44 → 315

SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
XM_036165574.1 → XP_036021467.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X1

Conserved Domains (1) summary

cd01409
Location:85 → 356

SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
XM_036165576.1 → XP_036021469.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X3

Conserved Domains (1) summary

cd01409
Location:44 → 305

SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...
XM_006530481.4 → XP_006530544.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X4

See identical proteins and their annotated locations for XP_006530544.1

Conserved Domains (1) summary

cd01409
Location:44 → 315

SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...