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Slamf7 SLAM family member 7 [ Mus musculus (house mouse) ]

Gene ID: 75345, updated on 9-Dec-2024

Summary

Official Symbol
Slamf7provided by MGI
Official Full Name
SLAM family member 7provided by MGI
Primary source
MGI:MGI:1922595
See related
Ensembl:ENSMUSG00000038179 AllianceGenome:MGI:1922595
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
19A; CS1; 19A24; CRACC; 4930560D03Rik
Summary
Predicted to enable identical protein binding activity. Acts upstream of or within regulation of natural killer cell activation. Located in external side of plasma membrane. Orthologous to human SLAMF7 (SLAM family member 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in testis adult (RPKM 3.6), spleen adult (RPKM 2.3) and 10 other tissues See more
Orthologs
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Genomic context

See Slamf7 in Genome Data Viewer
Location:
1 H3; 1 79.54 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171458506..171480522, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171632403..171653037, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03041 Neighboring gene predicted gene, 35200 Neighboring gene CD244 molecule A Neighboring gene STARR-positive B cell enhancer ABC_E5848 Neighboring gene lymphocyte antigen 9 Neighboring gene STARR-positive B cell enhancer ABC_E5849 Neighboring gene STARR-positive B cell enhancer ABC_E800 Neighboring gene microRNA 7683 Neighboring gene STARR-positive B cell enhancer ABC_E11696 Neighboring gene STARR-positive B cell enhancer ABC_E2586 Neighboring gene CD48 antigen Neighboring gene translational machinery associated 7 homolog (S. cerevisiae), pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding  
enables protein binding PubMed 
Process Evidence Code Pubs
involved_in T cell activation  
involved_in adaptive immune response  
involved_in immune response  
involved_in innate immune response  
acts_upstream_of_or_within regulation of natural killer cell activation PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane  
located_in external side of plasma membrane PubMed 
located_in plasma membrane PubMed 

General protein information

Preferred Names
SLAM family member 7
Names
leukocyte cell-surface antigen
novel Ly9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347184.2NP_001334113.1  SLAM family member 7 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC083892, AC091521
    Consensus CDS
    CCDS83636.1
    UniProtKB/TrEMBL
    A0A0A6YW73, A0A0A6YWL9
    Related
    ENSMUSP00000141426.2, ENSMUST00000192024.6
    Conserved Domains (1) summary
    cl11960
    Location:31122
    Ig; Immunoglobulin domain
  2. NM_001412826.1NP_001399755.1  SLAM family member 7 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC083892, AC091521
    UniProtKB/Swiss-Prot
    Q8BHK6, Q8BTL2, Q8CJ63, Q8CJ64, Q8CJ65, Q91XA0
    UniProtKB/TrEMBL
    A0A0R4J2D8
    Related
    ENSMUSP00000106907.4, ENSMUST00000111276.9
  3. NM_144539.6NP_653122.2  SLAM family member 7 isoform 1 precursor

    See identical proteins and their annotated locations for NP_653122.2

    Status: VALIDATED

    Source sequence(s)
    AC083892, AC091521
    Consensus CDS
    CCDS15500.1
    UniProtKB/Swiss-Prot
    Q8BHK6, Q8BTL2, Q8CJ63, Q8CJ64, Q8CJ65, Q91XA0
    UniProtKB/TrEMBL
    A0A0R4J2D8
    Related
    ENSMUSP00000141871.2, ENSMUST00000192195.6
    Conserved Domains (1) summary
    cl11960
    Location:31122
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    171458506..171480522 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238876.4XP_011237178.1  SLAM family member 7 isoform X2

    See identical proteins and their annotated locations for XP_011237178.1

    UniProtKB/Swiss-Prot
    Q8BHK6, Q8BTL2, Q8CJ63, Q8CJ64, Q8CJ65, Q91XA0
    UniProtKB/TrEMBL
    A0A0R4J2D8
    Conserved Domains (1) summary
    cl11960
    Location:31122
    Ig; Immunoglobulin domain
  2. XM_030243259.2XP_030099119.1  SLAM family member 7 isoform X3

    UniProtKB/TrEMBL
    A0A0A6YW73, A0A0A6YWL9
    Conserved Domains (1) summary
    cl11960
    Location:31122
    Ig; Immunoglobulin domain
  3. XM_036154079.1XP_036009972.1  SLAM family member 7 isoform X4

    UniProtKB/TrEMBL
    Q18PI2
    Conserved Domains (2) summary
    cd00096
    Location:1621
    Ig; Ig strand D [structural motif]
    cl11960
    Location:761
    Ig; Immunoglobulin domain
  4. XM_036154066.1XP_036009959.1  SLAM family member 7 isoform X1

    UniProtKB/TrEMBL
    A0A0R4J2D6, Q18PI2
    Related
    ENSMUSP00000141259.2, ENSMUST00000194531.6
    Conserved Domains (2) summary
    cd00096
    Location:2732
    Ig; Ig strand A [structural motif]
    cl11960
    Location:27122
    Ig; Immunoglobulin domain
  5. XM_011238875.4XP_011237177.1  SLAM family member 7 isoform X1

    See identical proteins and their annotated locations for XP_011237177.1

    UniProtKB/TrEMBL
    A0A0R4J2D6, Q18PI2
    Conserved Domains (2) summary
    cd00096
    Location:2732
    Ig; Ig strand A [structural motif]
    cl11960
    Location:27122
    Ig; Immunoglobulin domain
  6. XM_011238874.4XP_011237176.2  SLAM family member 7 isoform X1

    UniProtKB/TrEMBL
    A0A0R4J2D6, Q18PI2
    Conserved Domains (2) summary
    cd00096
    Location:2732
    Ig; Ig strand A [structural motif]
    cl11960
    Location:27122
    Ig; Immunoglobulin domain
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