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4930550C14Rik RIKEN cDNA 4930550C14 gene [ Mus musculus (house mouse) ]

Gene ID: 75311, updated on 5-Mar-2024

Summary

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Official Symbol
4930550C14Rikprovided by MGI
Official Full Name
RIKEN cDNA 4930550C14 geneprovided by MGI
Primary source
MGI:MGI:1922561
See related
Ensembl:ENSMUSG00000005131 AllianceGenome:MGI:1922561
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mfi
Summary
Involved in negative regulation of mitochondrial fission and negative regulation of protein targeting to mitochondrion. Located in cytosol and mitochondrial outer membrane. Orthologous to human C11orf65 (chromosome 11 open reading frame 65). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 2.2), whole brain E14.5 (RPKM 0.2) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See 4930550C14Rik in Genome Data Viewer
Location:
9 A5.3; 9 29.12 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (53313814..53345726)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (53402713..53434426)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene exophilin 5 Neighboring gene STARR-seq mESC enhancer starr_24141 Neighboring gene protein O-glucosyltransferase 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:53213128-53213311 Neighboring gene microRNA 130c Neighboring gene ataxia telangiectasia mutated Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:53344652-53344897 Neighboring gene nuclear protein in the AT region Neighboring gene STARR-seq mESC enhancer starr_24146

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A Genetic Interaction Map of Insulin Production Identifies Mfi as an Inhibitor of Mitochondrial Fission. Lee J, et al. Endocrinology, 2018 Sep 1. PMID 30059978, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of mitochondrial fission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein targeting to mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein MFI
Names
mitochondrial fission factor interactor
protein C11orf65 homolog
uncharacterized protein C11orf65 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001376943.1 → NP_001363872.1  protein MFI isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC079869
    UniProtKB/Swiss-Prot
    Q3U5F8, Q9D4W2
    Conserved Domains (1) summary
    cd21090
    Location:9 → 263
    C11orf65; chromosome 11 open reading frame 65 and homologs

  2. NM_001376944.1 → NP_001363873.1  protein MFI isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC079869
    UniProtKB/Swiss-Prot
    Q3U5F8, Q9D4W2
    Conserved Domains (1) summary
    cd21090
    Location:9 → 263
    C11orf65; chromosome 11 open reading frame 65 and homologs

  3. NM_001376945.1 → NP_001363874.1  protein MFI isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC079869, AK153618
    UniProtKB/TrEMBL
    Q14BS3
    Related
    ENSMUSP00000150018.2, ENSMUST00000215668.2

  4. NM_029247.4 → NP_083523.1  protein MFI isoform 1

    See identical proteins and their annotated locations for NP_083523.1

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC079869, AK016083, AK153618
    Consensus CDS
    CCDS23183.1
    UniProtKB/Swiss-Prot
    Q3U5F8, Q9D4W2
    Related
    ENSMUSP00000005262.2, ENSMUST00000005262.2
    Conserved Domains (1) summary
    cd21090
    Location:9 → 263
    C11orf65; chromosome 11 open reading frame 65 and homologs

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    53313814..53345726
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155365.1 → XP_036011258.1  protein MFI isoform X2

    Conserved Domains (1) summary
    cd21090
    Location:9 → 232
    C11orf65; chromosome 11 open reading frame 65 and homologs

  2. XM_006510654.5 → XP_006510717.1  protein MFI isoform X1

    See identical proteins and their annotated locations for XP_006510717.1

    UniProtKB/Swiss-Prot
    Q3U5F8, Q9D4W2
    Conserved Domains (1) summary
    cd21090
    Location:9 → 263
    C11orf65; chromosome 11 open reading frame 65 and homologs

  3. XM_036155364.1 → XP_036011257.1  protein MFI isoform X1

    UniProtKB/Swiss-Prot
    Q3U5F8, Q9D4W2
    Conserved Domains (1) summary
    cd21090
    Location:9 → 263
    C11orf65; chromosome 11 open reading frame 65 and homologs

  4. XM_006510656.5 → XP_006510719.1  protein MFI isoform X2

    Conserved Domains (1) summary
    cd21090
    Location:9 → 232
    C11orf65; chromosome 11 open reading frame 65 and homologs

  5. XM_006510660.5 → XP_006510723.1  protein MFI isoform X3

    See identical proteins and their annotated locations for XP_006510723.1

    UniProtKB/TrEMBL
    Q14BS3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D4W2.1 GenPept UniProtKB/Swiss-Prot:Q9D4W2

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