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LDLRAD4 low density lipoprotein receptor class A domain containing 4 [ Homo sapiens (human) ]

Gene ID: 753, updated on 3-Apr-2024

Summary

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Official Symbol
LDLRAD4provided by HGNC
Official Full Name
low density lipoprotein receptor class A domain containing 4provided by HGNC
Primary source
HGNC:HGNC:1224
See related
Ensembl:ENSG00000168675 MIM:606571; AllianceGenome:HGNC:1224
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C18orf1
Summary
Enables R-SMAD binding activity. Involved in negative regulation of cell migration; negative regulation of epithelial to mesenchymal transition; and negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Located in early endosome membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 2.9), prostate (RPKM 1.4) and 24 other tissues See more
Orthologs
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Genomic context

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See LDLRAD4 in Genome Data Viewer
Location:
18p11.21
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (13217682..13652754)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (13380438..13815606)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (13217681..13652753)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904254 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:13165229-13165802 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:13165803-13166374 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:13180459-13181093 Neighboring gene uncharacterized LOC124904255 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9331 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9332 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9333 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13239687-13240321 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:13262681-13263619 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13265910-13266472 Neighboring gene Sharpr-MPRA regulatory region 6698 Neighboring gene chromosome 18 putative open reading frame 15 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13272589-13273088 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13114 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:13280210-13280710 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:13280711-13281211 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:13286315-13286868 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13291758-13292268 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:13302309-13302494 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13303607-13304108 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13304109-13304608 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13318811-13319312 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:13320779-13321278 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr18:13366195-13366842 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:13375117-13376316 Neighboring gene Sharpr-MPRA regulatory region 1453 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13379815-13380316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13380317-13380816 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13381508-13382132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13116 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13425961-13426523 Neighboring gene LDLRAD4 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:13447027-13447730 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:13446323-13447026 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13454951-13455594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13455595-13456240 Neighboring gene Sharpr-MPRA regulatory region 5399 Neighboring gene uncharacterized LOC124904256 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13474023-13474524 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13474525-13475024 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:13493407-13493936 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:13493937-13494464 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:13500239-13500896 Neighboring gene microRNA 5190 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13541887-13542410 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13542411-13542932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13548044-13548993 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13550257-13550758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13117 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13119 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13566667-13567294 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13121 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13122 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13124 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13125 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13613273-13613792 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13613793-13614310 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13126 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13127 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13616337-13616838 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13623209-13623708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13626114-13626614 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13649057-13649558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:13649559-13650058 Neighboring gene microRNA 4526 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:13672949-13674148 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr18:13675367-13676566 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:13688247-13688792 Neighboring gene family with sequence similarity 210 member A Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:13725735-13726660 Neighboring gene RNA, 7SL, cytoplasmic 362, pseudogene Neighboring gene RNA guanine-7 methyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of low-density lipoprotein receptor class A domain containing 4 (LDLRAD4) as a prognostic indicator in primary gastrointestinal stromal tumors. Xie W, et al. Curr Probl Cancer, 2020 Dec. PMID 32507364
  2. Analysis of a t(18;21)(p11.1;p11.1) translocation in a family with schizophrenia. Meerabux JM, et al. J Hum Genet, 2009 Jul. PMID 19461657
  3. C18orf1 located on chromosome 18p11.2 may confer susceptibility to schizophrenia. Kikuchi M, et al. J Med Dent Sci, 2003 Sep. PMID 15074360
  4. Multiple transcriptional variants and RNA editing in C18orf1, a novel gene with LDLRA and transmembrane domains on 18p11.2. Yoshikawa T, et al. Genomics, 1998 Jan 15. PMID 9479497
  5. An integrated physical map of 18p11.2: a susceptibility region for bipolar disorder. Esterling LE, et al. Mol Psychiatry, 1997 Oct-Nov. PMID 9399696

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of low-density lipoprotein receptor class A domain containing 4 (LDLRAD4) as a prognostic indicator in primary gastrointestinal stromal tumors.
    Title: Identification of low-density lipoprotein receptor class A domain containing 4 (LDLRAD4) as a prognostic indicator in primary gastrointestinal stromal tumors.
  2. Depletion of LDLRAD4 in HepG2 liver cancer cells inhibited tumorigenesis in nude mice. These results reveal an oncogenic role of LDLRAD4 in tumorigenesis through its association with Nedd4.
    Title: Low density lipoprotein receptor class A domain containing 4 (LDLRAD4) promotes tumorigenesis of hepatic cancer cells.
  3. Data suggest that C18ORF1 acts as a gatekeeper that abrogates excessive TGF-beta signaling.
    Title: C18 ORF1, a novel negative regulator of transforming growth factor-β signaling.
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.
  6. Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Genome-wide association study of blood pressure and hypertension.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of survival in patients with pancreatic adenocarcinoma.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables R-SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables R-SMAD binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of SMAD protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
low-density lipoprotein receptor class A domain-containing protein 4
Names
clone 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003674.3 → NP_001003674.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform gamma 1

    See identical proteins and their annotated locations for NP_001003674.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon, differs in its 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant a1. The encoded isoform (gamma 1) is shorter and has a distinct N-terminus, compared to isoform alpha 1.
    Source sequence(s)
    AF009426, AI668861, AI878844, AK055028, AP001010, DA321390, DA391326, DA412541, HY309264
    Consensus CDS
    CCDS32795.1
    UniProtKB/TrEMBL
    A8K6A9
    Related
    ENSP00000466178.1, ENST00000587757.5

  2. NM_001003675.3 → NP_001003675.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform gamma 2

    See identical proteins and their annotated locations for NP_001003675.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' terminal exon, differs in its 5' UTR, lacks a portion of the 5' coding region, initiates translation at an alternate start codon, and lacks an alternate in-frame exon in the central coding region, compared to variant a1. The encoded isoform (gamma 2) is shorter and has a distinct N-terminus, compared to isoform alpha 1.
    Source sequence(s)
    AF009424, AI878844, AP001010, BC047093, BC066971, BM991627, BX114947, DA126127, DA246476, DA276009, HY115972
    Consensus CDS
    CCDS42415.1
    UniProtKB/TrEMBL
    A0A7I2V2E6
    Related
    ENSP00000474783.1, ENST00000586765.1

  3. NM_001276249.1 → NP_001263178.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform delta 1

    See identical proteins and their annotated locations for NP_001263178.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate 5' terminal exon, differs in its 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant a1. The encoded isoform (delta 1) is shorter at the N-terminus, compared to isoform alpha 1.
    Source sequence(s)
    AF009426, AI878844, AK291574, AP001010, BC030199, BC066971, BM715555, BM805426, DA418068, DC327672, DC328561
    Consensus CDS
    CCDS62392.1
    UniProtKB/TrEMBL
    A8K6A9
    Related
    ENSP00000466772.1, ENST00000585931.5

  4. NM_001276251.2 → NP_001263180.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform epsilon 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains an alternate 5' terminal exon, differs in its 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant a1. The encoded isoform (epsilon 1) is shorter and has a distinct N-terminus, compared to isoform alpha 1.
    Source sequence(s)
    AF009424, AI878844, AP001010, BC029958, BC066971, HY309264, N63974
    UniProtKB/TrEMBL
    A8K6A9

  5. NM_001378098.1 → NP_001365027.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform alpha 1

    Status: VALIDATED

    Source sequence(s)
    AP001010, AP002439, AP002505
    Consensus CDS
    CCDS32793.1
    UniProtKB/Swiss-Prot
    B3KNT9, E9PAY9, K7EN38, O15165, O15166, O15167, O15168, Q5U646, Q6NXP3
    Conserved Domains (1) summary
    cd00112
    Location:16 → 47
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  6. NM_001378099.1 → NP_001365028.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform alpha 1

    Status: VALIDATED

    Source sequence(s)
    AP001010, AP002439, AP002505
    Consensus CDS
    CCDS32793.1
    UniProtKB/Swiss-Prot
    B3KNT9, E9PAY9, K7EN38, O15165, O15166, O15167, O15168, Q5U646, Q6NXP3
    Related
    ENSP00000503185.1, ENST00000679091.1
    Conserved Domains (1) summary
    cd00112
    Location:16 → 47
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  7. NM_001378100.1 → NP_001365029.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform alpha 1

    Status: VALIDATED

    Source sequence(s)
    AP001010, AP002439, AP002505
    Consensus CDS
    CCDS32793.1
    UniProtKB/Swiss-Prot
    B3KNT9, E9PAY9, K7EN38, O15165, O15166, O15167, O15168, Q5U646, Q6NXP3
    Related
    ENSP00000352420.5, ENST00000359446.11
    Conserved Domains (1) summary
    cd00112
    Location:16 → 47
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  8. NM_001378101.1 → NP_001365030.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform alpha 2

    Status: VALIDATED

    Source sequence(s)
    AP001010, AP002439, AP002505
    Consensus CDS
    CCDS32794.1
    Conserved Domains (1) summary
    cd00112
    Location:16 → 47
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  9. NM_001394662.1 → NP_001381591.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform alpha 1

    Status: VALIDATED

    Source sequence(s)
    AP001010, AP002439, AP002505
    Consensus CDS
    CCDS32793.1
    UniProtKB/Swiss-Prot
    B3KNT9, E9PAY9, K7EN38, O15165, O15166, O15167, O15168, Q5U646, Q6NXP3
    Conserved Domains (1) summary
    cd00112
    Location:16 → 47
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  10. NM_001394663.1 → NP_001381592.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform alpha 1

    Status: VALIDATED

    Source sequence(s)
    AP001010, AP002439, AP002505
    Consensus CDS
    CCDS32793.1
    UniProtKB/Swiss-Prot
    B3KNT9, E9PAY9, K7EN38, O15165, O15166, O15167, O15168, Q5U646, Q6NXP3
    Conserved Domains (1) summary
    cd00112
    Location:16 → 47
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  11. NM_001394664.1 → NP_001381593.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform alpha 2

    Status: VALIDATED

    Source sequence(s)
    AP001010, AP002439, AP002505
    Consensus CDS
    CCDS32794.1
    Conserved Domains (1) summary
    cd00112
    Location:16 → 47
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  12. NM_001394665.1 → NP_001381594.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform alpha 2

    Status: VALIDATED

    Source sequence(s)
    AP001010, AP002439, AP002505
    Consensus CDS
    CCDS32794.1
    Conserved Domains (1) summary
    cd00112
    Location:16 → 47
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  13. NM_001394666.1 → NP_001381595.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AP001010, AP002439, AP002505
    Consensus CDS
    CCDS92439.1
    UniProtKB/TrEMBL
    A0A7I2V575, A8K6A9
    Related
    ENSP00000504217.1, ENST00000679177.1

  14. NM_001394667.1 → NP_001381596.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AP001010, AP002439, AP002505
    Consensus CDS
    CCDS92439.1
    UniProtKB/TrEMBL
    A0A7I2V575, A8K6A9
    Related
    ENSP00000504651.1, ENST00000679167.1

  15. NM_181481.5 → NP_852146.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform alpha 1

    See identical proteins and their annotated locations for NP_852146.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (alpha 1).
    Source sequence(s)
    AP001010, AP002439, AP002505
    Consensus CDS
    CCDS32793.1
    UniProtKB/Swiss-Prot
    B3KNT9, E9PAY9, K7EN38, O15165, O15166, O15167, O15168, Q5U646, Q6NXP3
    Conserved Domains (1) summary
    cd00112
    Location:16 → 47
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  16. NM_181482.5 → NP_852147.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform alpha 2

    See identical proteins and their annotated locations for NP_852147.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in its 5' UTR and lacks an alternate in-frame exon in the central coding region, compared to variant a1, resulting in an isoform (alpha 2) that is shorter than isoform alpha 1.
    Source sequence(s)
    AF009424, AI878844, AP001010, BC030199, BM715555, DB107684, DB272592
    Consensus CDS
    CCDS32794.1
    UniProtKB/Swiss-Prot
    O15165
    Related
    ENSP00000382741.2, ENST00000399848.7
    Conserved Domains (1) summary
    cd00112
    Location:16 → 47
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

RNA

  1. NR_172142.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP001010, AP002439, AP002505, AP005131

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    13217682..13652754
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047437773.1 → XP_047293729.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    B3KNT9, E9PAY9, K7EN38, O15165, O15166, O15167, O15168, Q5U646, Q6NXP3

  2. XM_047437776.1 → XP_047293732.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X2

  3. XM_024451260.2 → XP_024307028.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X5

    UniProtKB/TrEMBL
    A0A7I2V2E6

  4. XM_047437785.1 → XP_047293741.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X5

  5. XM_047437774.1 → XP_047293730.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X2

  6. XM_047437779.1 → XP_047293735.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X4

    UniProtKB/TrEMBL
    A0A7I2V575

  7. XM_047437783.1 → XP_047293739.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X5

  8. XM_047437772.1 → XP_047293728.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    B3KNT9, E9PAY9, K7EN38, O15165, O15166, O15167, O15168, Q5U646, Q6NXP3

  9. XM_047437778.1 → XP_047293734.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X3

  10. XM_024451250.2 → XP_024307018.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    B3KNT9, E9PAY9, K7EN38, O15165, O15166, O15167, O15168, Q5U646, Q6NXP3
    Conserved Domains (1) summary
    cd00112
    Location:16 → 47
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  11. XM_047437775.1 → XP_047293731.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X2

  12. XM_047437784.1 → XP_047293740.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X5

  13. XM_047437786.1 → XP_047293742.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X6

  14. XM_047437787.1 → XP_047293743.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X6

  15. XM_047437788.1 → XP_047293744.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X6

  16. XM_006722353.2 → XP_006722416.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006722416.1

    UniProtKB/Swiss-Prot
    B3KNT9, E9PAY9, K7EN38, O15165, O15166, O15167, O15168, Q5U646, Q6NXP3
    Conserved Domains (1) summary
    cd00112
    Location:16 → 47
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  17. XM_047437777.1 → XP_047293733.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X3

  18. XM_047437791.1 → XP_047293747.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X6

  19. XM_047437780.1 → XP_047293736.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X4

    UniProtKB/TrEMBL
    A0A7I2V575

  20. XM_017025961.2 → XP_016881450.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X2

  21. XM_011525737.2 → XP_011524039.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X4

    UniProtKB/TrEMBL
    A0A7I2V575, A8K6A9
    Related
    ENSP00000504396.1, ENST00000677055.1

  22. XM_047437782.1 → XP_047293738.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X5

  23. XM_024451254.2 → XP_024307022.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    B3KNT9, E9PAY9, K7EN38, O15165, O15166, O15167, O15168, Q5U646, Q6NXP3
    Conserved Domains (1) summary
    cd00112
    Location:16 → 47
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  24. XM_024451256.2 → XP_024307024.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    B3KNT9, E9PAY9, K7EN38, O15165, O15166, O15167, O15168, Q5U646, Q6NXP3
    Conserved Domains (1) summary
    cd00112
    Location:16 → 47
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  25. XM_024451252.2 → XP_024307020.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    B3KNT9, E9PAY9, K7EN38, O15165, O15166, O15167, O15168, Q5U646, Q6NXP3
    Conserved Domains (1) summary
    cd00112
    Location:16 → 47
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  26. XM_024451251.2 → XP_024307019.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    B3KNT9, E9PAY9, K7EN38, O15165, O15166, O15167, O15168, Q5U646, Q6NXP3
    Conserved Domains (1) summary
    cd00112
    Location:16 → 47
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  27. XM_024451255.2 → XP_024307023.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    B3KNT9, E9PAY9, K7EN38, O15165, O15166, O15167, O15168, Q5U646, Q6NXP3
    Conserved Domains (1) summary
    cd00112
    Location:16 → 47
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  28. XM_047437781.1 → XP_047293737.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X4

    UniProtKB/TrEMBL
    A0A7I2V575

  29. XM_024451258.2 → XP_024307026.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    B3KNT9, E9PAY9, K7EN38, O15165, O15166, O15167, O15168, Q5U646, Q6NXP3
    Conserved Domains (1) summary
    cd00112
    Location:16 → 47
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  30. XM_006722354.2 → XP_006722417.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006722417.1

    UniProtKB/Swiss-Prot
    B3KNT9, E9PAY9, K7EN38, O15165, O15166, O15167, O15168, Q5U646, Q6NXP3
    Conserved Domains (1) summary
    cd00112
    Location:16 → 47
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  31. XM_047437790.1 → XP_047293746.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X6

  32. XM_017025970.2 → XP_016881459.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X6

    UniProtKB/TrEMBL
    A8K6A9
    Conserved Domains (1) summary
    cl21455
    Location:97 → 155
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  33. XM_047437792.1 → XP_047293748.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X6

  34. XM_047437789.1 → XP_047293745.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X6

  35. XM_017025969.2 → XP_016881458.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X6

    UniProtKB/TrEMBL
    A8K6A9
    Related
    ENSP00000504022.1, ENST00000677744.1
    Conserved Domains (1) summary
    cl21455
    Location:97 → 155
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    13380438..13815606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319055.1 → XP_054175030.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    B3KNT9, E9PAY9, K7EN38, O15165, O15166, O15167, O15168, Q5U646, Q6NXP3

  2. XM_054319065.1 → XP_054175040.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X2

  3. XM_054319076.1 → XP_054175051.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X5

  4. XM_054319075.1 → XP_054175050.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X5

  5. XM_054319069.1 → XP_054175044.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X4

    UniProtKB/TrEMBL
    A0A7I2V575

  6. XM_054319073.1 → XP_054175048.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X5

  7. XM_054319054.1 → XP_054175029.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    B3KNT9, E9PAY9, K7EN38, O15165, O15166, O15167, O15168, Q5U646, Q6NXP3

  8. XM_054319067.1 → XP_054175042.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X3

  9. XM_054319052.1 → XP_054175027.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    B3KNT9, E9PAY9, K7EN38, O15165, O15166, O15167, O15168, Q5U646, Q6NXP3

  10. XM_054319064.1 → XP_054175039.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X2

  11. XM_054319074.1 → XP_054175049.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X5

  12. XM_054319058.1 → XP_054175033.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    B3KNT9, E9PAY9, K7EN38, O15165, O15166, O15167, O15168, Q5U646, Q6NXP3

  13. XM_054319077.1 → XP_054175052.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X6

  14. XM_054319078.1 → XP_054175053.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X6

  15. XM_054319079.1 → XP_054175054.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X6

  16. XM_054319057.1 → XP_054175032.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    B3KNT9, E9PAY9, K7EN38, O15165, O15166, O15167, O15168, Q5U646, Q6NXP3

  17. XM_054319066.1 → XP_054175041.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X3

  18. XM_054319084.1 → XP_054175059.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X6

  19. XM_054319070.1 → XP_054175045.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X4

    UniProtKB/TrEMBL
    A0A7I2V575

  20. XM_054319068.1 → XP_054175043.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X4

    UniProtKB/TrEMBL
    A0A7I2V575

  21. XM_054319072.1 → XP_054175047.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X5

  22. XM_054319061.1 → XP_054175036.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    B3KNT9, E9PAY9, K7EN38, O15165, O15166, O15167, O15168, Q5U646, Q6NXP3

  23. XM_054319053.1 → XP_054175028.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    B3KNT9, E9PAY9, K7EN38, O15165, O15166, O15167, O15168, Q5U646, Q6NXP3

  24. XM_054319059.1 → XP_054175034.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    B3KNT9, E9PAY9, K7EN38, O15165, O15166, O15167, O15168, Q5U646, Q6NXP3

  25. XM_054319060.1 → XP_054175035.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    B3KNT9, E9PAY9, K7EN38, O15165, O15166, O15167, O15168, Q5U646, Q6NXP3

  26. XM_054319071.1 → XP_054175046.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X4

    UniProtKB/TrEMBL
    A0A7I2V575

  27. XM_054319062.1 → XP_054175037.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    B3KNT9, E9PAY9, K7EN38, O15165, O15166, O15167, O15168, Q5U646, Q6NXP3

  28. XM_054319056.1 → XP_054175031.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    B3KNT9, E9PAY9, K7EN38, O15165, O15166, O15167, O15168, Q5U646, Q6NXP3

  29. XM_054319082.1 → XP_054175057.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X6

  30. XM_054319083.1 → XP_054175058.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X6

  31. XM_054319086.1 → XP_054175061.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X6

  32. XM_054319085.1 → XP_054175060.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X6

  33. XM_054319081.1 → XP_054175056.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X6

  34. XM_054319080.1 → XP_054175055.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X6

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_004338.3: Suppressed sequence

    Description
    NM_004338.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

  2. NM_181483.3: Suppressed sequence

    Description
    NM_181483.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15165.1 GenPept UniProtKB/Swiss-Prot:O15165

Gene LinkOut

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